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Pyrin MeSH Descriptor Data 2022


MeSH Heading
Pyrin
Tree Number(s)
D12.776.220.909
D12.776.934.750
Unique ID
D000071198
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D000071198
Scope Note
A tripartite motif protein that consists of an N-terminal pyrin domain, a central coiled-coil region and B-box type ZINC FINGER, and C-terminal regions that mediate homotrimerization and interactions with other proteins (the B30.2/SPRY DOMAIN). It is expressed primarily by mature GRANULOCYTES and associates with the cytoskeleton in the perinuclear area as well as AUTOPHAGOSOMES, where it co-ordinates the assembly of AUTOPHAGY-RELATED PROTEINS and degradation of INFLAMMASOME components. It functions in INNATE IMMUNITY and INFLAMMATION; mutations in the Pyrin protein (MEFV) gene are associated with FAMILIAL MEDITERRANEAN FEVER.
Entry Term(s)
MEFV Protein
Marenostrin
Mediterranean Fever Protein
TRIM20 Protein
Registry Number
0
See Also
Pyrin Domain
Public MeSH Note
2017; PYRIN was indexed under PROTEINS 1997; and under CYTOSKELETAL PROTEINS 1998-2016
History Note
2017 (1997)
Date Established
2017/01/01
Date of Entry
2016/07/08
Revision Date
2016/07/05
Pyrin Preferred
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