- Concept UI
- M0281114
- Registry Numbers
- 0
- Scope Note
- A tripartite motif protein that consists of an N-terminal pyrin domain, a central coiled-coil region and B-box type ZINC FINGER, and C-terminal regions that mediate homotrimerization and interactions with other proteins (the B30.2/SPRY DOMAIN). It is expressed primarily by mature GRANULOCYTES and associates with the cytoskeleton in the perinuclear area as well as AUTOPHAGOSOMES, where it co-ordinates the assembly of AUTOPHAGY-RELATED PROTEINS and degradation of INFLAMMASOME components. It functions in INNATE IMMUNITY and INFLAMMATION; mutations in the Pyrin protein (MEFV) gene are associated with FAMILIAL MEDITERRANEAN FEVER.
- Terms
-
Pyrin
Preferred Term
Term UI
T000893683
Date01/15/2016
LexicalTag
NON
ThesaurusID
NLM (19XX)
-
Marenostrin
Term UI
T000893681
Date01/15/2016
LexicalTag
NON
ThesaurusID
NLM (1997)
-
MEFV Protein
Term UI
T000893682
Date01/15/2016
LexicalTag
ABX
ThesaurusID
NLM (2005)
-
Mediterranean Fever Protein
Term UI
T000893684
Date01/15/2016
LexicalTag
NON
ThesaurusID
NLM (2017)
-
TRIM20 Protein
Term UI
T000893685
Date01/15/2016
LexicalTag
ABX
ThesaurusID
NLM (2017)