MeSH Browser

MeSH Heading: Pyrin
Tree Number(s): D12.776.220.909; D12.776.934.750
Unique ID: D000071198
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D000071198
Scope Note: A tripartite motif protein that consists of an N-terminal pyrin domain, a central coiled-coil region and B-box type ZINC FINGER, and C-terminal regions that mediate homotrimerization and interactions with other proteins (the B30.2/SPRY DOMAIN). It is expressed primarily by mature GRANULOCYTES and associates with the cytoskeleton in the perinuclear area as well as AUTOPHAGOSOMES, where it co-ordinates the assembly of AUTOPHAGY-RELATED PROTEINS and degradation of INFLAMMASOME components. It functions in INNATE IMMUNITY and INFLAMMATION; mutations in the Pyrin protein (MEFV) gene are associated with FAMILIAL MEDITERRANEAN FEVER.
Entry Term(s): MEFV Protein; Marenostrin; Mediterranean Fever Protein; TRIM20 Protein
See Also: Pyrin Domain
Public MeSH Note: 2017; PYRIN was indexed under PROTEINS 1997; and under CYTOSKELETAL PROTEINS 1998-2016
History Note: 2017 (1997)
Date Established: 2017/01/01
Date of Entry: 2016/07/08
Revision Date: 2016/07/05

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M0281114
Scope Note: A tripartite motif protein that consists of an N-terminal pyrin domain, a central coiled-coil region and B-box type ZINC FINGER, and C-terminal regions that mediate homotrimerization and interactions with other proteins (the B30.2/SPRY DOMAIN). It is expressed primarily by mature GRANULOCYTES and associates with the cytoskeleton in the perinuclear area as well as AUTOPHAGOSOMES, where it co-ordinates the assembly of AUTOPHAGY-RELATED PROTEINS and degradation of INFLAMMASOME components. It functions in INNATE IMMUNITY and INFLAMMATION; mutations in the Pyrin protein (MEFV) gene are associated with FAMILIAL MEDITERRANEAN FEVER.
Terms: Pyrin Preferred Term
Term UI T000893683
Date01/15/2016
LexicalTag NON
ThesaurusID NLM (19XX); Marenostrin
Term UI T000893681
Date01/15/2016
LexicalTag NON
ThesaurusID NLM (1997); MEFV Protein
Term UI T000893682
Date01/15/2016
LexicalTag ABX
ThesaurusID NLM (2005); Mediterranean Fever Protein
Term UI T000893684
Date01/15/2016
LexicalTag NON
ThesaurusID NLM (2017); TRIM20 Protein
Term UI T000893685
Date01/15/2016
LexicalTag ABX
ThesaurusID NLM (2017)

Pyrin MeSH Descriptor Data 2025