MeSH Browser

MeSH Heading: Ezrin
Tree Number(s): D12.776.220.419
Unique ID: D000099149
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D000099149
Scope Note: A cytoskeletal protein and PROTEIN-TYROSINE KINASE substrate that links cytoskeletal structures to the PLASMA MEMBRANE. In EPITHELIAL CELLS, it is essential for the formation of MICROVILLI and membrane ruffles on the apical pole and is also required for macropinocytosis (see PINOCYTOSIS) along with the GUANINE NUCLEOTIDE EXCHANGE FACTOR PLEKHG6.
Entry Term(s): EZR Protein; Phosphoprotein p81; Villin-2
Registry Numbers: 0
Public MeSH Note: 2026; EZRIN was indexed under CYTOSKELETAL PROTEINS 2007-2025, and under PHOSPHOPROTEINS 1986-2006
History Note: 2026 (1986)
Date Introduced: 2026/01/01
Last Updated: 2026/01/01

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M000768754
Registry Numbers: 0
Scope Note: A cytoskeletal protein and PROTEIN-TYROSINE KINASE substrate that links cytoskeletal structures to the PLASMA MEMBRANE. In EPITHELIAL CELLS, it is essential for the formation of MICROVILLI and membrane ruffles on the apical pole and is also required for macropinocytosis (see PINOCYTOSIS) along with the GUANINE NUCLEOTIDE EXCHANGE FACTOR PLEKHG6.
Terms: Ezrin Preferred Term
Term UI T001147051
Date02/11/2025
LexicalTag NON
ThesaurusID NLM (1986); EZR Protein
Term UI T001147049
Date02/11/2025
LexicalTag ABX
ThesaurusID NLM (1986); Phosphoprotein p81
Term UI T001147052
Date02/11/2025
LexicalTag NON
ThesaurusID NLM (1986); Villin-2
Term UI T001147053
Date02/11/2025
LexicalTag NON
ThesaurusID NLM (2006)

Ezrin MeSH Descriptor Data 2026