MeSH Browser

MeSH Heading: AIRE Protein
Tree Number(s): D12.776.930.123
Unique ID: D000096927
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D000096927
Scope Note: A transcriptional regulator primarily expressed in medullary thymic epithelial cells. It plays an important role in immunity by regulating the expression of a wide array of SELF-ANTIGENS and negative selection of autoreactive T-cells in the thymus. Deficiency in this protein induces a rare autosomal-recessive disease called AUTOIMMUNE POLYENDOCRINOPATHY-CANDIDIASIS-ECTODERMAL DYSTROPHY.
Entry Term(s): APECED Protein; Autoimmune Polyendocrinopathy Candidiasis Ectodermal Dystrophy Protein; Autoimmune Regulator Protein
Public MeSH Note: 2024; AIRE PROTEIN was indexed under TRANSCRIPTION FACTORS 1997-2023
History Note: 2024 (1997)
Date Established: 2024/01/01
Date of Entry: 2023/07/26
Revision Date: 2023/05/16

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M000762772
Scope Note: A transcriptional regulator primarily expressed in medullary thymic epithelial cells. It plays an important role in immunity by regulating the expression of a wide array of SELF-ANTIGENS and negative selection of autoreactive T-cells in the thymus. Deficiency in this protein induces a rare autosomal-recessive disease called AUTOIMMUNE POLYENDOCRINOPATHY-CANDIDIASIS-ECTODERMAL DYSTROPHY.
Terms: AIRE Protein Preferred Term
Term UI T001133091
Date02/21/2023
LexicalTag NON
ThesaurusID NLM (2024); APECED Protein
Term UI T001133093
Date02/21/2023
LexicalTag ABX
ThesaurusID NLM (2024); Autoimmune Regulator Protein
Term UI T001133095
Date02/21/2023
LexicalTag NON
ThesaurusID NLM (2024); Autoimmune Polyendocrinopathy Candidiasis Ectodermal Dystrophy Protein
Term UI T001133145
Date02/22/2023
LexicalTag NON
ThesaurusID NLM (2024)

AIRE Protein MeSH Descriptor Data 2025