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Polyendocrinopathies, Autoimmune MeSH Descriptor Data 2023

MeSH Heading
Polyendocrinopathies, Autoimmune
Tree Number(s)
Unique ID
RDF Unique Identifier
do not coordinate with specific endocrine disease term or CANDIDIASIS unless particularly discussed
Scope Note
Autoimmune diseases affecting multiple endocrine organs. Type I is characterized by childhood onset and chronic mucocutaneous candidiasis (CANDIDIASIS, CHRONIC MUCOCUTANEOUS), while type II exhibits any combination of adrenal insufficiency (ADDISON'S DISEASE), lymphocytic thyroiditis (THYROIDITIS, AUTOIMMUNE;), HYPOPARATHYROIDISM; and gonadal failure. In both types organ-specific ANTIBODIES against a variety of ENDOCRINE GLANDS have been detected. The type II syndrome differs from type I in that it is associated with HLA-A1 and B8 haplotypes, onset is usually in adulthood, and candidiasis is not present.
Entry Term(s)
AIRE Deficiency
APS Type 1
Autoimmune Polyendocrine Syndrome, Type 2
Autoimmune Polyendocrine Syndrome, Type II
Autoimmune Polyendocrinopathy Syndrome Type 1
Autoimmune Polyendocrinopathy with Candidiasis and Ectodermal Dystrophy
Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy
Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal-Dystrophy
Autoimmune Polyglandular Syndrome Type I
Autoimmune Polyglandular Syndrome Type II
Autoimmune Polyglandular Syndrome Type III
Autoimmune Polyglandular Syndrome, Type 1
Autoimmune Polyglandular Syndrome, Type 3
Autoimmune Polyglandular Syndrome, Type I
Autoimmune Syndrome Type I, Polyglandular
Autoimmune Syndrome Type II, Polyglandular
Autoimmune Syndrome Type III, Polyglandular
Diabetes Mellitus, Addison Disease, Myxedema
Diabetes Mellitus, Addison's Disease, Myxedema
Multiple Endocrine Deficiency Syndrome, Type 2
Polyendocrine Autoimmune Syndrome, Type II
Polyendocrinopathy-Candidiasis-Ectodermal-Dystrophy, Autoimmune
Polyglandular Autoimmune Syndrome, Type 1
Polyglandular Autoimmune Syndrome, Type 2
Polyglandular Autoimmune Syndrome, Type 3
Polyglandular Autoimmune Syndrome, Type I
Polyglandular Deficiency Syndrome, Type 2
Polyglandular Type I Autoimmune Syndrome
Polyglandular Type II Autoimmune Syndrome
Polyglandular Type III Autoimmune Syndrome
Schmidt Syndrome
Schmidt's Syndrome
NLM Classification #
WK 140
Previous Indexing
Autoimmune Diseases (1968-1991)
Endocrine Diseases (1978-1991)
Public MeSH Note
History Note
Date Established
Date of Entry
Revision Date
Polyendocrinopathies, Autoimmune Preferred
Polyglandular Type III Autoimmune Syndrome Narrower
Polyglandular Type I Autoimmune Syndrome Narrower
Polyglandular Type II Autoimmune Syndrome Narrower
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