MeSH Browser

MeSH Heading: E2F Transcription Factors
Tree Number(s): D12.776.930.211
Unique ID: D050684
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D050684
Scope Note: A family of basic helix-loop-helix transcription factors that control expression of a variety of GENES involved in CELL CYCLE regulation. E2F transcription factors typically form heterodimeric complexes with TRANSCRIPTION FACTOR DP1 or transcription factor DP2, and they have N-terminal DNA binding and dimerization domains. E2F transcription factors can act as mediators of transcriptional repression or transcriptional activation.
Entry Term(s): E2F Proteins; E2F Transcription Factor; Transcription Factor E2F
Previous Indexing: Cell Cycle Proteins (1991-2005); DNA-Binding Proteins (1991-2005); Transcription Factors (1991-2005)
Public MeSH Note: 2006; E2F TRANSCRIPTION FACTORS was indexed under CELL CYCLE PROTEINS, DNA-BINDING PROTEINS, & TRANSCRIPTION FACTORS 1991-2005
History Note: 2006(1991)
Date Established: 2006/01/01
Date of Entry: 2005/06/30
Revision Date: 2020/05/27

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M0189005
Scope Note: A family of basic helix-loop-helix transcription factors that control expression of a variety of GENES involved in CELL CYCLE regulation. E2F transcription factors typically form heterodimeric complexes with TRANSCRIPTION FACTOR DP1 or transcription factor DP2, and they have N-terminal DNA binding and dimerization domains. E2F transcription factors can act as mediators of transcriptional repression or transcriptional activation.
Terms: E2F Transcription Factors Preferred Term
Term UI T219003
Date01/01/1955
LexicalTag ABX
ThesaurusID NLM (2006); Transcription Factor E2F
Term UI T219010
Date01/01/1955
LexicalTag ABX
ThesaurusID NLM (2006); E2F Proteins
Term UI T622453
Date12/07/2004
LexicalTag ABX
ThesaurusID NLM (2006); E2F Transcription Factor
Term UI T001008576
Date02/25/2020
LexicalTag NON
ThesaurusID NLM (2021)

E2F Transcription Factors MeSH Descriptor Data 2025