- Concept UI
- M000625941
- Registry Numbers
- 0
- Scope Note
- A zinc finger transcription factor that contains five CYS2-HIS2 ZINC FINGERS and binds to the GLI consensus sequence 5'-GGGTGGTC-3'. The full-length protein functions as a transcriptional activator whereas the truncated C-terminal form functions as a transcriptional repressor of the Sonic Hedgehog (Shh) signaling pathway; a balance between these two forms is critical for limb and digit development. GLI3 also plays a critical role in the differentiation and proliferation of CHONDROCYTES.
- Terms
-
Zinc Finger Protein Gli3
Preferred Term
Term UI
T000914752
Date01/26/2017
LexicalTag
ABX
ThesaurusID
NLM (2018)
-
GLI-Kruppel Family Member 3 Protein
Term UI
T000914754
Date01/26/2017
LexicalTag
ABX
ThesaurusID
NLM (2018)
-
Glioma-Associated Oncogene Family Zinc Finger 3 Protein
Term UI
T000914755
Date01/26/2017
LexicalTag
NON
ThesaurusID
NLM (2018)