MeSH Browser

MeSH Heading: Zinc Finger Protein Gli3
Tree Number(s): D12.776.260.522.875; D12.776.260.703.900; D12.776.930.375.875; D12.776.930.780.972
Unique ID: D000074290
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D000074290
Scope Note: A zinc finger transcription factor that contains five CYS2-HIS2 ZINC FINGERS and binds to the GLI consensus sequence 5'-GGGTGGTC-3'. The full-length protein functions as a transcriptional activator whereas the truncated C-terminal form functions as a transcriptional repressor of the Sonic Hedgehog (Shh) signaling pathway; a balance between these two forms is critical for limb and digit development. GLI3 also plays a critical role in the differentiation and proliferation of CHONDROCYTES.
Entry Term(s): GLI-Kruppel Family Member 3 Protein; Glioma-Associated Oncogene Family Zinc Finger 3 Protein
Previous Indexing: DNA-Binding Proteins (1990-2017); Kruppel-Like Transcription Factors (2006-2017); Nerve Tissue Proteins (2006-2017); Transcription Factors (1990-2017)
Public MeSH Note: 2018
History Note: 2018
Date Established: 2018/01/01
Date of Entry: 2017/07/11
Revision Date: 2017/02/27

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M000625941
Scope Note: A zinc finger transcription factor that contains five CYS2-HIS2 ZINC FINGERS and binds to the GLI consensus sequence 5'-GGGTGGTC-3'. The full-length protein functions as a transcriptional activator whereas the truncated C-terminal form functions as a transcriptional repressor of the Sonic Hedgehog (Shh) signaling pathway; a balance between these two forms is critical for limb and digit development. GLI3 also plays a critical role in the differentiation and proliferation of CHONDROCYTES.
Terms: Zinc Finger Protein Gli3 Preferred Term
Term UI T000914752
Date01/26/2017
LexicalTag ABX
ThesaurusID NLM (2018); GLI-Kruppel Family Member 3 Protein
Term UI T000914754
Date01/26/2017
LexicalTag ABX
ThesaurusID NLM (2018); Glioma-Associated Oncogene Family Zinc Finger 3 Protein
Term UI T000914755
Date01/26/2017
LexicalTag NON
ThesaurusID NLM (2018)

Zinc Finger Protein Gli3 MeSH Descriptor Data 2025