MeSH Browser

MeSH Heading: Promyelocytic Leukemia Zinc Finger Protein
Tree Number(s): D12.776.260.522.625; D12.776.930.375.625
Unique ID: D000075722
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D000075722
Scope Note: A Kruppel-type transcription factor consisting of an N-terminal BTB DOMAIN and nine CYS2-HIS2 ZINC FINGERS. It localizes to the nucleus and regulates cell cycle progression and gene expression for tissue development and homeostasis; it may also function as an epigenetic regulator through its interactions with HISTONE DEACETYLASE. Genetic rearrangements involving the ZBTB16 gene are associated with ACUTE PROMYELOCYTIC LEUKEMIA.
Entry Term(s): PLZF Protein; Promyelocytic Leukaemia Zinc Finger Protein; ZBTB16 Protein; Zinc Finger and BTB Domain Containing 16 Protein
Previous Indexing: Kruppel-Like Transcription Factors (1995-2017)
Public MeSH Note: 2018
History Note: 2018
Date Established: 2018/01/01
Date of Entry: 2017/07/11
Revision Date: 2018/05/21

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M000631303
Scope Note: A Kruppel-type transcription factor consisting of an N-terminal BTB DOMAIN and nine CYS2-HIS2 ZINC FINGERS. It localizes to the nucleus and regulates cell cycle progression and gene expression for tissue development and homeostasis; it may also function as an epigenetic regulator through its interactions with HISTONE DEACETYLASE. Genetic rearrangements involving the ZBTB16 gene are associated with ACUTE PROMYELOCYTIC LEUKEMIA.
Terms: Promyelocytic Leukemia Zinc Finger Protein Preferred Term
Term UI T000923801
Date05/09/2017
LexicalTag NON
ThesaurusID NLM (2018); Promyelocytic Leukaemia Zinc Finger Protein
Term UI T000923804
Date05/09/2017
LexicalTag NON
ThesaurusID NLM (2018); ZBTB16 Protein
Term UI T000923805
Date05/09/2017
LexicalTag ABX
ThesaurusID NLM (2018); PLZF Protein
Term UI T000923802
Date05/09/2017
LexicalTag ABB
ThesaurusID NLM (2018); Zinc Finger and BTB Domain Containing 16 Protein
Term UI T000923803
Date05/09/2017
LexicalTag ABX
ThesaurusID NLM (2018)

Promyelocytic Leukemia Zinc Finger Protein MeSH Descriptor Data 2025