MeSH Browser

MeSH Heading: Protein Methyltransferases
Tree Number(s): D08.811.913.555.500.800
Unique ID: D011496
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D011496
Annotation: do not confuse with PROTEIN O-METHYLTRANSFERASE
Scope Note: Enzymes that catalyze the methylation of amino acids after their incorporation into a polypeptide chain. S-Adenosyl-L-methionine acts as the methylating agent. EC 2.1.1.
Entry Term(s): Protein Methylase; Protein Methylases; Protein Methyltransferase
Related Numbers: 9068-28-4
NLM Classification #: QU 141
Previous Indexing: Methyltransferases (1971-1976); Proteins (1966-1976); S-Adenosylmethionine (1971-1976); specific protein
Public MeSH Note: 77
History Note: 77
Date Established: 1977/01/01
Date of Entry: 1976/05/19
Revision Date: 2020/06/18

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Enzymes and Coenzymes [D08]
- Enzymes [D08.811]
  - Transferases [D08.811.913]
    - One-Carbon Group Transferases [D08.811.913.555]
      - Methyltransferases [D08.811.913.555.500]
        
        Acetylserotonin O-Methyltransferase [D08.811.913.555.500.100]
        
        Betaine-Homocysteine S-Methyltransferase [D08.811.913.555.500.175]
        
        Catechol O-Methyltransferase [D08.811.913.555.500.250]
        
        DNA Modification Methylases [D08.811.913.555.500.350]
        
        Glycine N-Methyltransferase [D08.811.913.555.500.387]
        
        Guanidinoacetate N-Methyltransferase [D08.811.913.555.500.425]
        
        Histamine N-Methyltransferase [D08.811.913.555.500.500]
        
        Homocysteine S-Methyltransferase [D08.811.913.555.500.625]
        
        5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase [D08.811.913.555.500.645]
        
        Nicotinamide N-Methyltransferase [D08.811.913.555.500.650]
        
        Phenylethanolamine N-Methyltransferase [D08.811.913.555.500.700]
        
        Phosphatidyl-N-Methylethanolamine N-Methyltransferase [D08.811.913.555.500.710]
        
        Phosphatidylethanolamine N-Methyltransferase [D08.811.913.555.500.712]
        
        Protein Methyltransferases [D08.811.913.555.500.800]
        
        Histone Methyltransferases [D08.811.913.555.500.800.200]
        
        O(6)-Methylguanine-DNA Methyltransferase [D08.811.913.555.500.800.650]
        
        Positive Regulatory Domain I-Binding Factor 1 [D08.811.913.555.500.800.700]
        
        Protein-Arginine N-Methyltransferases [D08.811.913.555.500.800.750]
        
        Protein O-Methyltransferase [D08.811.913.555.500.800.800]
        
        Thymidylate Synthase [D08.811.913.555.500.862]
        
        tRNA Methyltransferases [D08.811.913.555.500.925]

Protein Methyltransferases Preferred

Concept UI: M0017871
Related Numbers: 9068-28-4
Scope Note: Enzymes that catalyze the methylation of amino acids after their incorporation into a polypeptide chain. S-Adenosyl-L-methionine acts as the methylating agent. EC 2.1.1.
Terms: Protein Methyltransferases Preferred Term
Term UI T033959
Date01/01/1999
LexicalTag NON
ThesaurusID NLM (1977); Protein Methylase
Term UI T001082768
Date06/17/2020
LexicalTag NON
ThesaurusID NLM (2021); Protein Methyltransferase
Term UI T001082769
Date06/17/2020
LexicalTag NON
ThesaurusID NLM (2021); Protein Methylases
Term UI T033958
Date05/12/1976
LexicalTag NON
ThesaurusID UNK (19XX)

Protein Methyltransferases MeSH Descriptor Data 2025