MeSH Browser

MeSH Heading: DNA Modification Methylases
Tree Number(s): D08.811.150.240; D08.811.913.555.500.350
Unique ID: D015254
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D015254
Scope Note: Enzymes that are part of the restriction-modification systems. They are responsible for producing a species-characteristic methylation pattern, on either adenine or cytosine residues, in a specific short base sequence in the host cell's own DNA. This methylated sequence will occur many times in the host-cell DNA and remain intact for the lifetime of the cell. Any DNA from another species which gains entry into a living cell and lacks the characteristic methylation pattern will be recognized by the restriction endonucleases of similar specificity and destroyed by cleavage. Most have been studied in bacterial systems, but a few have been found in eukaryotic organisms.
Entry Term(s): DNA Modification Methyltransferases; Modification Methylases
Previous Indexing: DNA (Cytosine-5-)-Methyltransferase (1975-1988); Methyltransferases (1971-1988)
Public MeSH Note: 1989
History Note: 1989
Date Established: 1989/01/01
Date of Entry: 1988/05/17
Revision Date: 2003/07/09

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Enzymes and Coenzymes [D08]
- Enzymes [D08.811]
  - DNA Restriction-Modification Enzymes [D08.811.150]
    - DNA Modification Methylases [D08.811.150.240]
    - DNA Restriction Enzymes [D08.811.150.280]

Enzymes and Coenzymes [D08]
- Enzymes [D08.811]
  - Transferases [D08.811.913]
    - One-Carbon Group Transferases [D08.811.913.555]
      - Methyltransferases [D08.811.913.555.500]
        
        Acetylserotonin O-Methyltransferase [D08.811.913.555.500.100]
        
        Betaine-Homocysteine S-Methyltransferase [D08.811.913.555.500.175]
        
        Catechol O-Methyltransferase [D08.811.913.555.500.250]
        
        DNA Modification Methylases [D08.811.913.555.500.350]
        
        DNA-Cytosine Methylases [D08.811.913.555.500.350.100]
        
        Site-Specific DNA-Methyltransferase (Adenine-Specific) [D08.811.913.555.500.350.700]
        
        Glycine N-Methyltransferase [D08.811.913.555.500.387]
        
        Guanidinoacetate N-Methyltransferase [D08.811.913.555.500.425]
        
        Histamine N-Methyltransferase [D08.811.913.555.500.500]
        
        Homocysteine S-Methyltransferase [D08.811.913.555.500.625]
        
        5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase [D08.811.913.555.500.645]
        
        Nicotinamide N-Methyltransferase [D08.811.913.555.500.650]
        
        Phenylethanolamine N-Methyltransferase [D08.811.913.555.500.700]
        
        Phosphatidyl-N-Methylethanolamine N-Methyltransferase [D08.811.913.555.500.710]
        
        Phosphatidylethanolamine N-Methyltransferase [D08.811.913.555.500.712]
        
        Protein Methyltransferases [D08.811.913.555.500.800]
        
        Thymidylate Synthase [D08.811.913.555.500.862]
        
        tRNA Methyltransferases [D08.811.913.555.500.925]

DNA Modification Methylases Preferred

Concept UI: M0023492
Scope Note: Enzymes that are part of the restriction-modification systems. They are responsible for producing a species-characteristic methylation pattern, on either adenine or cytosine residues, in a specific short base sequence in the host cell's own DNA. This methylated sequence will occur many times in the host-cell DNA and remain intact for the lifetime of the cell. Any DNA from another species which gains entry into a living cell and lacks the characteristic methylation pattern will be recognized by the restriction endonucleases of similar specificity and destroyed by cleavage. Most have been studied in bacterial systems, but a few have been found in eukaryotic organisms.
Terms: DNA Modification Methylases Preferred Term
Term UI T044775
Date01/01/1999
LexicalTag ACX
ThesaurusID NLM (1989); DNA Modification Methyltransferases
Term UI T044776
Date05/17/1988
LexicalTag NON
ThesaurusID UNK (19XX); Modification Methylases
Term UI T044777
Date05/17/1988
LexicalTag NON
ThesaurusID UNK (19XX)

DNA Modification Methylases MeSH Descriptor Data 2025