MeSH Browser

MeSH Heading: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase
Tree Number(s): D08.811.913.555.500.645
Unique ID: D013766
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D013766
Annotation: /defic: consider also HOMOCYSTINURIA
Scope Note: An enzyme that catalyzes the formation of methionine by transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine. It requires a cobamide coenzyme. The enzyme can act on mono- or triglutamate derivatives. EC 2.1.1.13.
Entry Term(s): Methionine Synthase; Methionine Synthetase; Methyltetrahydrofolate Homocysteine Methyltransferase; Tetrahydropteroylglutamate Methyltransferase; Vitamin B12-Dependent Methionine Synthase; Vitamin B12-Independent Methionine Synthase
Registry Number: EC 2.1.1.13
Related Numbers: 9033-23-2
CAS Type 1 Name: 5-Methyltetrahydropteroyltri-L-glutamate:L-homocysteine S-methyltransferase
Previous Indexing: Methionine (1973-1974); Methyltransferases (1973-1974); Tetrahydrofolates (1973-1974)
See Also: Homocystinuria
Public MeSH Note: 98; see TETRAHYDROPTEROYLGLUTAMATE METHYLTRANSFERASE 1991-97; see METHYLTRANSFERASES 1975-90
History Note: 98(75)
Date Established: 1991/01/01
Date of Entry: 1974/11/19
Revision Date: 2005/06/30

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M0021236
Registry Number: EC 2.1.1.13
Related Numbers: 9033-23-2
Scope Note: An enzyme that catalyzes the formation of methionine by transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine. It requires a cobamide coenzyme. The enzyme can act on mono- or triglutamate derivatives. EC 2.1.1.13.
Terms: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase Preferred Term
Term UI T040446
Date01/01/1999
LexicalTag NON
ThesaurusID NLM (1975); Methyltetrahydrofolate Homocysteine Methyltransferase
Term UI T040443
Date11/11/1974
LexicalTag NON
ThesaurusID UNK (19XX); Methionine Synthase
Term UI T040445
Date09/17/1984
LexicalTag NON
ThesaurusID UNK (19XX); Methionine Synthetase
Term UI T040442
Date11/11/1974
LexicalTag NON
ThesaurusID UNK (19XX); Tetrahydropteroylglutamate Methyltransferase
Term UI T040444
Date12/03/1996
LexicalTag NON
ThesaurusID NLM (1998)

5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase MeSH Descriptor Data 2023