MeSH Browser

MeSH Heading: DNA Restriction-Modification Enzymes
Tree Number(s): D08.811.150
Unique ID: D015280
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D015280
Scope Note: Systems consisting of two enzymes, a modification methylase and a restriction endonuclease. They are closely related in their specificity and protect the DNA of a given bacterial species. The methylase adds methyl groups to adenine or cytosine residues in the same target sequence that constitutes the restriction enzyme binding site. The methylation renders the target site resistant to restriction, thereby protecting DNA against cleavage.
Entry Version: RESTRICT MOD ENZYMES
Entry Term(s): DNA Restriction Modification Enzyme; DNA Restriction Modification Enzymes; DNA Restriction-Modification Enzyme; Restriction Modification System; Restriction Modification Systems; Restriction-Modification System; Restriction-Modification Systems
Previous Indexing: DNA Restriction Enzymes (1975-1988); Methyltransferases (1971-1988)
Public MeSH Note: 89
History Note: 89
Date Established: 1989/01/01
Date of Entry: 1988/05/23
Revision Date: 2020/05/27

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Enzymes and Coenzymes [D08]
- Enzymes [D08.811]

DNA Restriction-Modification Enzymes Preferred

Concept UI: M0023522
Scope Note: Systems consisting of two enzymes, a modification methylase and a restriction endonuclease. They are closely related in their specificity and protect the DNA of a given bacterial species. The methylase adds methyl groups to adenine or cytosine residues in the same target sequence that constitutes the restriction enzyme binding site. The methylation renders the target site resistant to restriction, thereby protecting DNA against cleavage.
Terms: DNA Restriction-Modification Enzymes Preferred Term
Term UI T044890
Date01/01/1999
LexicalTag ACX
ThesaurusID NLM (1989); Restriction Modification System
Term UI T000997149
Date11/18/2019
LexicalTag NON
ThesaurusID NLM (2021); DNA Restriction-Modification Enzyme
Term UI T000997150
Date11/18/2019
LexicalTag NON
ThesaurusID NLM (2021); DNA Restriction Modification Enzyme
Term UI T000997151
Date11/18/2019
LexicalTag NON
ThesaurusID NLM (2021); DNA Restriction Modification Enzymes
Term UI T044889
Date05/23/1988
LexicalTag NON
ThesaurusID UNK (19XX); Restriction-Modification System
Term UI T000997152
Date11/18/2019
LexicalTag NON
ThesaurusID NLM (2021); Restriction Modification Systems
Term UI T044891
Date05/23/1988
LexicalTag NON
ThesaurusID UNK (19XX); Restriction-Modification Systems
Term UI T044892
Date05/23/1988
LexicalTag NON
ThesaurusID UNK (19XX)

DNA Restriction-Modification Enzymes MeSH Descriptor Data 2025