MeSH Browser

MeSH Heading: Integrin alpha2beta1
Tree Number(s): D09.400.430.890.625.298; D12.776.395.550.625.298; D12.776.543.550.625.298; D12.776.543.750.685.200; D12.776.543.750.705.408.530.249; D12.776.543.750.705.408.850.199; D12.776.543.750.705.675.352; D12.776.543.750.705.876.280
Unique ID: D038982
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D038982
Scope Note: An integrin found on fibroblasts, platelets, endothelial and epithelial cells, and lymphocytes where it functions as a receptor for COLLAGEN and LAMININ. Although originally referred to as the collagen receptor, it is one of several receptors for collagen. Ligand binding to integrin alpha2beta1 triggers a cascade of intracellular signaling, including activation of p38 MAP kinase.
Entry Term(s): CD49b-CD29; Glycoprotein Ia-IIa; Platelet Membrane Glycoprotein Heterodimer Ia-IIa; VLA-2; Very Late Antigen-2; alpha2beta1Integrin
Previous Indexing: Collagen Receptors (1991-2002); Integrins (1994-2002)
Public MeSH Note: 2003; INTEGRIN ALPHA2BETA1 was indexed under INTEGRINS 1994-2002
History Note: 2003; for VLA-2 use COLLAGEN RECEPTORS (NM) 1991-2002; for PLATELET MEMBRANE GLYCOPROTEIN HETERODIMER IA-IIA use COLLAGEN RECEPTORS (NM) 1992-2000; for INTEGRIN ALPHA2BETA1 & CD49B-CD29 use COLLAGEN RECEPTORS (NM) 1994-2002; for ALPHA2BETA1INTEGRIN use COLLAGEN RECEPTORS (NM) 2001-2002
Date Established: 2003/01/01
Date of Entry: 2002/07/02
Revision Date: 2023/03/16

Allowable Qualifiers: administration & dosage (AD)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

physiology (PH)

radiation effects (RE)

therapeutic use (TU)

ultrastructure (UL)

Carbohydrates [D09]
- Glycoconjugates [D09.400]
  - Glycoproteins [D09.400.430]
    - Membrane Glycoproteins [D09.400.430.890]
      - Platelet Membrane Glycoproteins [D09.400.430.890.625]
        
        CD36 Antigens [D09.400.430.890.625.136]
        
        Integrin alpha2beta1 [D09.400.430.890.625.298]
        
        Integrin alpha5beta1 [D09.400.430.890.625.379]
        
        Integrin alpha6beta1 [D09.400.430.890.625.419]
        
        Integrin alphaVbeta3 [D09.400.430.890.625.439]
        
        Lysosomal-Associated Membrane Protein 1 [D09.400.430.890.625.449]
        
        Platelet Glycoprotein GPIb-IX Complex [D09.400.430.890.625.460]
        
        Platelet Glycoprotein GPIIb-IIIa Complex [D09.400.430.890.625.785]
        
        Receptors, Thrombin [D09.400.430.890.625.800]
        
        P-Selectin [D09.400.430.890.625.905]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Glycoproteins [D12.776.395]
    - Membrane Glycoproteins [D12.776.395.550]
      - Platelet Membrane Glycoproteins [D12.776.395.550.625]
        
        CD36 Antigens [D12.776.395.550.625.136]
        
        Integrin alpha2beta1 [D12.776.395.550.625.298]
        
        Integrin alpha5beta1 [D12.776.395.550.625.379]
        
        Integrin alpha6beta1 [D12.776.395.550.625.419]
        
        Integrin alphaVbeta3 [D12.776.395.550.625.439]
        
        Lysosomal-Associated Membrane Protein 1 [D12.776.395.550.625.449]
        
        Platelet Glycoprotein GPIb-IX Complex [D12.776.395.550.625.460]
        
        Platelet Glycoprotein GPIIb-IIIa Complex [D12.776.395.550.625.785]
        
        Receptors, Thrombin [D12.776.395.550.625.800]
        
        P-Selectin [D12.776.395.550.625.905]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Membrane Proteins [D12.776.543]
    - Membrane Glycoproteins [D12.776.543.550]
      - Platelet Membrane Glycoproteins [D12.776.543.550.625]
        
        CD36 Antigens [D12.776.543.550.625.136]
        
        Integrin alpha2beta1 [D12.776.543.550.625.298]
        
        Integrin alpha5beta1 [D12.776.543.550.625.379]
        
        Integrin alpha6beta1 [D12.776.543.550.625.419]
        
        Integrin alphaVbeta3 [D12.776.543.550.625.439]
        
        Lysosomal-Associated Membrane Protein 1 [D12.776.543.550.625.449]
        
        Platelet Glycoprotein GPIb-IX Complex [D12.776.543.550.625.460]
        
        Platelet Glycoprotein GPIIb-IIIa Complex [D12.776.543.550.625.785]
        
        Receptors, Thrombin [D12.776.543.550.625.800]
        
        P-Selectin [D12.776.543.550.625.905]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Membrane Proteins [D12.776.543]
    - Receptors, Cell Surface [D12.776.543.750]
      - Receptors, Collagen [D12.776.543.750.685]
        
        Discoidin Domain Receptors [D12.776.543.750.685.050]
        
        Integrin alpha1beta1 [D12.776.543.750.685.100]
        
        Integrin alpha2beta1 [D12.776.543.750.685.200]
        
        Integrin alpha3beta1 [D12.776.543.750.685.300]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Membrane Proteins [D12.776.543]
    - Receptors, Cell Surface [D12.776.543.750]
      - Receptors, Immunologic [D12.776.543.750.705]
        
        Integrins [D12.776.543.750.705.408]
        
        Receptors, Fibronectin [D12.776.543.750.705.408.530]
        
        Integrin alpha2beta1 [D12.776.543.750.705.408.530.249]
        
        Integrin alpha4beta1 [D12.776.543.750.705.408.530.500]
        
        Integrin alpha5beta1 [D12.776.543.750.705.408.530.750]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Membrane Proteins [D12.776.543]
    - Receptors, Cell Surface [D12.776.543.750]
      - Receptors, Immunologic [D12.776.543.750.705]
        
        Integrins [D12.776.543.750.705.408]
        
        Receptors, Very Late Antigen [D12.776.543.750.705.408.850]
        
        Integrin alpha1beta1 [D12.776.543.750.705.408.850.099]
        
        Integrin alpha2beta1 [D12.776.543.750.705.408.850.199]
        
        Integrin alpha3beta1 [D12.776.543.750.705.408.850.249]
        
        Integrin alpha4beta1 [D12.776.543.750.705.408.850.299]
        
        Integrin alpha5beta1 [D12.776.543.750.705.408.850.349]
        
        Integrin alpha6beta1 [D12.776.543.750.705.408.850.674]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Membrane Proteins [D12.776.543]
    - Receptors, Cell Surface [D12.776.543.750]
      - Receptors, Immunologic [D12.776.543.750.705]
        
        Platelet Membrane Glycoproteins [D12.776.543.750.705.675]
        
        CD36 Antigens [D12.776.543.750.705.675.136]
        
        Integrin alpha2beta1 [D12.776.543.750.705.675.352]
        
        Integrin alpha5beta1 [D12.776.543.750.705.675.460]
        
        Integrin alpha6beta1 [D12.776.543.750.705.675.514]
        
        Integrin alphaVbeta3 [D12.776.543.750.705.675.541]
        
        Lysosomal-Associated Membrane Protein 1 [D12.776.543.750.705.675.554]
        
        Platelet Glycoprotein GPIb-IX Complex [D12.776.543.750.705.675.568]
        
        Platelet Glycoprotein GPIIb-IIIa Complex [D12.776.543.750.705.675.784]
        
        Receptors, Thrombin [D12.776.543.750.705.675.892]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Membrane Proteins [D12.776.543]
    - Receptors, Cell Surface [D12.776.543.750]
      - Receptors, Immunologic [D12.776.543.750.705]
        
        Receptors, Laminin [D12.776.543.750.705.876]
        
        Integrin alpha1beta1 [D12.776.543.750.705.876.249]
        
        Integrin alpha2beta1 [D12.776.543.750.705.876.280]
        
        Integrin alpha3beta1 [D12.776.543.750.705.876.311]
        
        Integrin alpha5beta1 [D12.776.543.750.705.876.374]
        
        Integrin alpha6beta1 [D12.776.543.750.705.876.500]
        
        Integrin alpha6beta4 [D12.776.543.750.705.876.750]

Integrin alpha2beta1 Preferred

Concept UI: M0417889
Scope Note: An integrin found on fibroblasts, platelets, endothelial and epithelial cells, and lymphocytes where it functions as a receptor for COLLAGEN and LAMININ. Although originally referred to as the collagen receptor, it is one of several receptors for collagen. Ligand binding to integrin alpha2beta1 triggers a cascade of intracellular signaling, including activation of p38 MAP kinase.
Terms: Integrin alpha2beta1 Preferred Term
Term UI T141800
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2003); CD49b-CD29
Term UI T141796
Date01/01/1955
LexicalTag ACX
ThesaurusID NLM (2003); VLA-2
Term UI T141797
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2003); Glycoprotein Ia-IIa
Term UI T490241
Date04/19/2002
LexicalTag NON
ThesaurusID NLM (2003); Platelet Membrane Glycoprotein Heterodimer Ia-IIa
Term UI T141801
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2003); alpha2beta1Integrin
Term UI T452946
Date06/30/2001
LexicalTag NON
ThesaurusID NLM (2003); Very Late Antigen-2
Term UI T490220
Date04/19/2002
LexicalTag NON
ThesaurusID NLM (2003)

Integrin alpha2beta1 MeSH Descriptor Data 2025