MeSH Browser

MeSH Heading: Integrin alpha5beta1
Tree Number(s): D09.400.430.890.625.379; D12.776.395.550.625.379; D12.776.543.550.625.379; D12.776.543.750.705.408.530.750; D12.776.543.750.705.408.850.349; D12.776.543.750.705.675.460; D12.776.543.750.705.876.374
Unique ID: D039081
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D039081
Annotation: do not confuse entry term FIBRONECTIN RECEPTOR with RECEPTORS, FIBRONECTIN
Scope Note: An integrin found in FIBROBLASTS; PLATELETS; MONOCYTES, and LYMPHOCYTES. Integrin alpha5beta1 is the classical receptor for FIBRONECTIN, but it also functions as a receptor for LAMININ and several other EXTRACELLULAR MATRIX PROTEINS.
Entry Term(s): Fibronectin Receptor; Integrin alpha-5 beta-1; Platelet Glycoprotein Ic-IIa; Receptors, VLA-5; VLA-5; VLA-5 Receptors
Previous Indexing: Receptors, Fibronectin (1992-2002)
Public MeSH Note: 2003; see RECEPTORS, FIBRONECTIN 1992-2002
History Note: 2003; use RECEPTORS, FIBRONECTIN 1992-2002
Date Established: 2003/01/01
Date of Entry: 2002/07/02
Revision Date: 2023/03/16

Allowable Qualifiers: administration & dosage (AD)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

physiology (PH)

radiation effects (RE)

therapeutic use (TU)

ultrastructure (UL)

Carbohydrates [D09]
- Glycoconjugates [D09.400]
  - Glycoproteins [D09.400.430]
    - Membrane Glycoproteins [D09.400.430.890]
      - Platelet Membrane Glycoproteins [D09.400.430.890.625]
        
        CD36 Antigens [D09.400.430.890.625.136]
        
        Integrin alpha2beta1 [D09.400.430.890.625.298]
        
        Integrin alpha5beta1 [D09.400.430.890.625.379]
        
        Integrin alpha6beta1 [D09.400.430.890.625.419]
        
        Integrin alphaVbeta3 [D09.400.430.890.625.439]
        
        Lysosomal-Associated Membrane Protein 1 [D09.400.430.890.625.449]
        
        Platelet Glycoprotein GPIb-IX Complex [D09.400.430.890.625.460]
        
        Platelet Glycoprotein GPIIb-IIIa Complex [D09.400.430.890.625.785]
        
        Receptors, Thrombin [D09.400.430.890.625.800]
        
        P-Selectin [D09.400.430.890.625.905]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Glycoproteins [D12.776.395]
    - Membrane Glycoproteins [D12.776.395.550]
      - Platelet Membrane Glycoproteins [D12.776.395.550.625]
        
        CD36 Antigens [D12.776.395.550.625.136]
        
        Integrin alpha2beta1 [D12.776.395.550.625.298]
        
        Integrin alpha5beta1 [D12.776.395.550.625.379]
        
        Integrin alpha6beta1 [D12.776.395.550.625.419]
        
        Integrin alphaVbeta3 [D12.776.395.550.625.439]
        
        Lysosomal-Associated Membrane Protein 1 [D12.776.395.550.625.449]
        
        Platelet Glycoprotein GPIb-IX Complex [D12.776.395.550.625.460]
        
        Platelet Glycoprotein GPIIb-IIIa Complex [D12.776.395.550.625.785]
        
        Receptors, Thrombin [D12.776.395.550.625.800]
        
        P-Selectin [D12.776.395.550.625.905]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Membrane Proteins [D12.776.543]
    - Membrane Glycoproteins [D12.776.543.550]
      - Platelet Membrane Glycoproteins [D12.776.543.550.625]
        
        CD36 Antigens [D12.776.543.550.625.136]
        
        Integrin alpha2beta1 [D12.776.543.550.625.298]
        
        Integrin alpha5beta1 [D12.776.543.550.625.379]
        
        Integrin alpha6beta1 [D12.776.543.550.625.419]
        
        Integrin alphaVbeta3 [D12.776.543.550.625.439]
        
        Lysosomal-Associated Membrane Protein 1 [D12.776.543.550.625.449]
        
        Platelet Glycoprotein GPIb-IX Complex [D12.776.543.550.625.460]
        
        Platelet Glycoprotein GPIIb-IIIa Complex [D12.776.543.550.625.785]
        
        Receptors, Thrombin [D12.776.543.550.625.800]
        
        P-Selectin [D12.776.543.550.625.905]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Membrane Proteins [D12.776.543]
    - Receptors, Cell Surface [D12.776.543.750]
      - Receptors, Immunologic [D12.776.543.750.705]
        
        Integrins [D12.776.543.750.705.408]
        
        Receptors, Fibronectin [D12.776.543.750.705.408.530]
        
        Integrin alpha2beta1 [D12.776.543.750.705.408.530.249]
        
        Integrin alpha4beta1 [D12.776.543.750.705.408.530.500]
        
        Integrin alpha5beta1 [D12.776.543.750.705.408.530.750]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Membrane Proteins [D12.776.543]
    - Receptors, Cell Surface [D12.776.543.750]
      - Receptors, Immunologic [D12.776.543.750.705]
        
        Integrins [D12.776.543.750.705.408]
        
        Receptors, Very Late Antigen [D12.776.543.750.705.408.850]
        
        Integrin alpha1beta1 [D12.776.543.750.705.408.850.099]
        
        Integrin alpha2beta1 [D12.776.543.750.705.408.850.199]
        
        Integrin alpha3beta1 [D12.776.543.750.705.408.850.249]
        
        Integrin alpha4beta1 [D12.776.543.750.705.408.850.299]
        
        Integrin alpha5beta1 [D12.776.543.750.705.408.850.349]
        
        Integrin alpha6beta1 [D12.776.543.750.705.408.850.674]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Membrane Proteins [D12.776.543]
    - Receptors, Cell Surface [D12.776.543.750]
      - Receptors, Immunologic [D12.776.543.750.705]
        
        Platelet Membrane Glycoproteins [D12.776.543.750.705.675]
        
        CD36 Antigens [D12.776.543.750.705.675.136]
        
        Integrin alpha2beta1 [D12.776.543.750.705.675.352]
        
        Integrin alpha5beta1 [D12.776.543.750.705.675.460]
        
        Integrin alpha6beta1 [D12.776.543.750.705.675.514]
        
        Integrin alphaVbeta3 [D12.776.543.750.705.675.541]
        
        Lysosomal-Associated Membrane Protein 1 [D12.776.543.750.705.675.554]
        
        Platelet Glycoprotein GPIb-IX Complex [D12.776.543.750.705.675.568]
        
        Platelet Glycoprotein GPIIb-IIIa Complex [D12.776.543.750.705.675.784]
        
        Receptors, Thrombin [D12.776.543.750.705.675.892]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Membrane Proteins [D12.776.543]
    - Receptors, Cell Surface [D12.776.543.750]
      - Receptors, Immunologic [D12.776.543.750.705]
        
        Receptors, Laminin [D12.776.543.750.705.876]
        
        Integrin alpha1beta1 [D12.776.543.750.705.876.249]
        
        Integrin alpha2beta1 [D12.776.543.750.705.876.280]
        
        Integrin alpha3beta1 [D12.776.543.750.705.876.311]
        
        Integrin alpha5beta1 [D12.776.543.750.705.876.374]
        
        Integrin alpha6beta1 [D12.776.543.750.705.876.500]
        
        Integrin alpha6beta4 [D12.776.543.750.705.876.750]

Integrin alpha5beta1 Preferred

Concept UI: M0418249
Scope Note: An integrin found in FIBROBLASTS; PLATELETS; MONOCYTES, and LYMPHOCYTES. Integrin alpha5beta1 is the classical receptor for FIBRONECTIN, but it also functions as a receptor for LAMININ and several other EXTRACELLULAR MATRIX PROTEINS.
Terms: Integrin alpha5beta1 Preferred Term
Term UI T052380
Date04/19/1995
LexicalTag NON
ThesaurusID NLM (1996); VLA-5 Receptors
Term UI T052378
Date05/13/1992
LexicalTag ACX
ThesaurusID NLM (1993); Receptors, VLA-5
Term UI T052379
Date05/13/1992
LexicalTag ACX
ThesaurusID NLM (1993); VLA-5
Term UI T052373
Date04/24/1992
LexicalTag ABB
ThesaurusID NLM (1993); Integrin alpha-5 beta-1
Term UI T052381
Date01/17/1995
LexicalTag NON
ThesaurusID NLM (1996); Fibronectin Receptor
Term UI T490202
Date04/19/2002
LexicalTag NON
ThesaurusID NLM (2003); Platelet Glycoprotein Ic-IIa
Term UI T814219
Date12/12/2011
LexicalTag NON
ThesaurusID NLM (2012)

Integrin alpha5beta1 MeSH Descriptor Data 2025