MeSH Browser

MeSH Heading: Platelet Glycoprotein GPIb-IX Complex
Tree Number(s): D09.400.430.890.625.460; D12.776.395.550.625.460; D12.776.543.550.625.460; D12.776.543.750.705.675.568
Unique ID: D019038
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D019038
Scope Note: Platelet membrane glycoprotein complex essential for normal platelet adhesion and clot formation at sites of vascular injury. It is composed of three polypeptides, GPIb alpha, GPIb beta, and GPIX. Glycoprotein Ib functions as a receptor for von Willebrand factor and for thrombin. Congenital deficiency of the GPIb-IX complex results in Bernard-Soulier syndrome. The platelet glycoprotein GPV associates with GPIb-IX and is also absent in Bernard-Soulier syndrome.
Entry Version: GPIB IX
Entry Term(s): Antigens, CD42a; Antigens, CD42b; Antigens, CD42c; Antigens, CD42d; CD42a Antigen; CD42a Antigens; CD42b Antigen; CD42b Antigens; CD42c Antigen; CD42c Antigens; CD42d Antigen; CD42d Antigens; Glycoprotein Ib; Glycoprotein Ib alpha; Glycoprotein Ib beta; Glycoprotein Ib-IX Complex; Platelet Glycoprotein IX; Platelet Membrane Glycoprotein IX; Platelet Membrane Glycoprotein Ib; Platelet Membrane Glycoprotein V
Previous Indexing: Platelet Membrane Glycoproteins (1987-1995)
Public MeSH Note: 96; PLATELET MEMBRANE GLYCOPROTEIN IB was see PLATELET MEMBRANE GLYCOPROTEINS 1987-95
Online Note: use PLATELET MEMBRANE GLYCOPROTEINS to search PLATELET MEMBRANE GLYCOPROTEIN IB 1987-95
History Note: 96; PLATELET MEMBRANE GLYCOPROTEIN IB was see PLATELET MEMBRANE GLYCOPROTEINS 1987-95
Entry Combination: deficiency:Bernard-Soulier Syndrome
Date Established: 1996/01/01
Date of Entry: 1995/05/26
Revision Date: 2023/03/16

Entry Combination: deficiency:Bernard-Soulier Syndrome
Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Carbohydrates [D09]
- Glycoconjugates [D09.400]
  - Glycoproteins [D09.400.430]
    - Membrane Glycoproteins [D09.400.430.890]
      - Platelet Membrane Glycoproteins [D09.400.430.890.625]
        
        CD36 Antigens [D09.400.430.890.625.136]
        
        Integrin alpha2beta1 [D09.400.430.890.625.298]
        
        Integrin alpha5beta1 [D09.400.430.890.625.379]
        
        Integrin alpha6beta1 [D09.400.430.890.625.419]
        
        Integrin alphaVbeta3 [D09.400.430.890.625.439]
        
        Lysosomal-Associated Membrane Protein 1 [D09.400.430.890.625.449]
        
        Platelet Glycoprotein GPIb-IX Complex [D09.400.430.890.625.460]
        
        Platelet Glycoprotein GPIIb-IIIa Complex [D09.400.430.890.625.785]
        
        Receptors, Thrombin [D09.400.430.890.625.800]
        
        P-Selectin [D09.400.430.890.625.905]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Glycoproteins [D12.776.395]
    - Membrane Glycoproteins [D12.776.395.550]
      - Platelet Membrane Glycoproteins [D12.776.395.550.625]
        
        CD36 Antigens [D12.776.395.550.625.136]
        
        Integrin alpha2beta1 [D12.776.395.550.625.298]
        
        Integrin alpha5beta1 [D12.776.395.550.625.379]
        
        Integrin alpha6beta1 [D12.776.395.550.625.419]
        
        Integrin alphaVbeta3 [D12.776.395.550.625.439]
        
        Lysosomal-Associated Membrane Protein 1 [D12.776.395.550.625.449]
        
        Platelet Glycoprotein GPIb-IX Complex [D12.776.395.550.625.460]
        
        Platelet Glycoprotein GPIIb-IIIa Complex [D12.776.395.550.625.785]
        
        Receptors, Thrombin [D12.776.395.550.625.800]
        
        P-Selectin [D12.776.395.550.625.905]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Membrane Proteins [D12.776.543]
    - Membrane Glycoproteins [D12.776.543.550]
      - Platelet Membrane Glycoproteins [D12.776.543.550.625]
        
        CD36 Antigens [D12.776.543.550.625.136]
        
        Integrin alpha2beta1 [D12.776.543.550.625.298]
        
        Integrin alpha5beta1 [D12.776.543.550.625.379]
        
        Integrin alpha6beta1 [D12.776.543.550.625.419]
        
        Integrin alphaVbeta3 [D12.776.543.550.625.439]
        
        Lysosomal-Associated Membrane Protein 1 [D12.776.543.550.625.449]
        
        Platelet Glycoprotein GPIb-IX Complex [D12.776.543.550.625.460]
        
        Platelet Glycoprotein GPIIb-IIIa Complex [D12.776.543.550.625.785]
        
        Receptors, Thrombin [D12.776.543.550.625.800]
        
        P-Selectin [D12.776.543.550.625.905]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Membrane Proteins [D12.776.543]
    - Receptors, Cell Surface [D12.776.543.750]
      - Receptors, Immunologic [D12.776.543.750.705]
        
        Platelet Membrane Glycoproteins [D12.776.543.750.705.675]
        
        CD36 Antigens [D12.776.543.750.705.675.136]
        
        Integrin alpha2beta1 [D12.776.543.750.705.675.352]
        
        Integrin alpha5beta1 [D12.776.543.750.705.675.460]
        
        Integrin alpha6beta1 [D12.776.543.750.705.675.514]
        
        Integrin alphaVbeta3 [D12.776.543.750.705.675.541]
        
        Lysosomal-Associated Membrane Protein 1 [D12.776.543.750.705.675.554]
        
        Platelet Glycoprotein GPIb-IX Complex [D12.776.543.750.705.675.568]
        
        Platelet Glycoprotein GPIIb-IIIa Complex [D12.776.543.750.705.675.784]
        
        Receptors, Thrombin [D12.776.543.750.705.675.892]

Platelet Glycoprotein GPIb-IX Complex Preferred

Platelet Membrane Glycoprotein Ib Narrower

Platelet Membrane Glycoprotein IX Narrower

Concept UI: M0028419
Terms: Platelet Membrane Glycoprotein IX Preferred Term
Term UI T056808
Date01/20/1995
LexicalTag NON
ThesaurusID NLM (1996); Platelet Glycoprotein IX
Term UI T056807
Date01/20/1995
LexicalTag NON
ThesaurusID NLM (1996); CD42a Antigen
Term UI T056809
Date03/13/1995
LexicalTag NON
ThesaurusID NLM (1996); Antigens, CD42a
Term UI T056810
Date03/13/1995
LexicalTag NON
ThesaurusID NLM (1996); CD42a Antigens
Term UI T056811
Date01/20/1995
LexicalTag NON
ThesaurusID NLM (1996)

Platelet Membrane Glycoprotein V Related

CD42b Antigens Narrower

Concept UI: M0028421
Terms: CD42b Antigens Preferred Term
Term UI T056816
Date01/20/1995
LexicalTag NON
ThesaurusID NLM (1996); Glycoprotein Ib alpha
Term UI T056813
Date01/20/1995
LexicalTag NON
ThesaurusID NLM (1996); CD42b Antigen
Term UI T056814
Date03/13/1995
LexicalTag NON
ThesaurusID NLM (1996); Antigens, CD42b
Term UI T056815
Date03/13/1995
LexicalTag NON
ThesaurusID NLM (1996)

CD42c Antigens Narrower

Concept UI: M0028422
Terms: CD42c Antigens Preferred Term
Term UI T056819
Date01/20/1995
LexicalTag NON
ThesaurusID NLM (1996); CD42c Antigen
Term UI T056817
Date03/13/1995
LexicalTag NON
ThesaurusID NLM (1996); Antigens, CD42c
Term UI T056818
Date03/13/1995
LexicalTag NON
ThesaurusID NLM (1996); Glycoprotein Ib beta
Term UI T056820
Date01/20/1995
LexicalTag NON
ThesaurusID NLM (1996)

CD42d Antigen Narrower

Platelet Glycoprotein GPIb-IX Complex MeSH Descriptor Data 2025