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Receptors, Thrombin MeSH Descriptor Data 2023


MeSH Heading
Receptors, Thrombin
Tree Number(s)
D12.776.395.550.625.800
D12.776.543.550.625.800
D12.776.543.750.695.875
D12.776.543.750.705.675.892
D12.776.543.750.750.850
D12.776.543.750.792.500
Unique ID
D018179
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D018179
Scope Note
A family of proteinase-activated receptors that are specific for THROMBIN. They are found primarily on PLATELETS and on ENDOTHELIAL CELLS. Activation of thrombin receptors occurs through the proteolytic action of THROMBIN, which cleaves the N-terminal peptide from the receptor to reveal a new N-terminal peptide that is a cryptic ligand for the receptor. The receptors signal through HETEROTRIMERIC GTP-BINDING PROTEINS. Small synthetic peptides that contain the unmasked N-terminal peptide sequence can also activate the receptor in the absence of proteolytic activity.
Entry Version
RECEPT THROMBIN
Entry Term(s)
TRAP Peptide
Thrombin Receptor
Thrombin Receptor Activating Peptide Ligand
Thrombin Receptor Activating Peptides
Thrombin Receptor Activator Peptide
Thrombin Receptors
Registry Number
0
Previous Indexing
Proteins (2000-2003)
Receptors, Cell Surface (1981-1993)
Public MeSH Note
1994; THROMBIN RECEPTOR was indexed under RECEPTORS, ENDOGENOUS SUBSTANCES 1981-1993; TRAP PEPTIDE was indexed under PROTEINS 2000-2003
History Note
1994; use THROMBIN RECEPTOR (NM) 1981-1993; for TRAP PEPTIDE use RECEPTORS, THROMBIN (NM) 2000-2003
Date Established
1994/01/01
Date of Entry
1993/06/30
Revision Date
2016/06/17
Receptors, Thrombin Preferred
Thrombin Receptor Activating Peptides Narrower
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