- Concept UI
- M0028424
- Registry Numbers
- 0
- Scope Note
- Platelet membrane glycoprotein complex important for platelet adhesion and aggregation. It is an integrin complex containing INTEGRIN ALPHAIIB and INTEGRIN BETA3 which recognizes the arginine-glycine-aspartic acid (RGD) sequence present on several adhesive proteins. As such, it is a receptor for FIBRINOGEN; VON WILLEBRAND FACTOR; FIBRONECTIN; VITRONECTIN; and THROMBOSPONDINS. A deficiency of GPIIb-IIIa results in GLANZMANN THROMBASTHENIA.
- Terms
-
Platelet Glycoprotein GPIIb-IIIa Complex
Preferred Term
Term UI
T056830
Date01/01/1999
LexicalTag
ACX
ThesaurusID
NLM (1996)
-
Integrin alpha-IIb beta-3
Term UI
T056829
Date01/20/1995
LexicalTag
NON
ThesaurusID
NLM (1996)
-
Glycoproteins IIb-IIIa
Term UI
T056826
Date01/20/1995
LexicalTag
NON
ThesaurusID
NLM (1996)
-
Integrin alphaIIbbeta3
Term UI
T056827
Date04/19/1995
LexicalTag
NON
ThesaurusID
NLM (1996)
-
GPIIb-IIIa Receptors
Term UI
T056828
Date01/20/1995
LexicalTag
NON
ThesaurusID
NLM (1996)