MeSH Browser

MeSH Heading: Platelet Glycoprotein GPIIb-IIIa Complex
Tree Number(s): D09.400.430.890.625.785; D12.776.395.550.625.785; D12.776.543.550.625.785; D12.776.543.750.705.408.460.700; D12.776.543.750.705.675.784
Unique ID: D019039
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D019039
Scope Note: Platelet membrane glycoprotein complex important for platelet adhesion and aggregation. It is an integrin complex containing INTEGRIN ALPHAIIB and INTEGRIN BETA3 which recognizes the arginine-glycine-aspartic acid (RGD) sequence present on several adhesive proteins. As such, it is a receptor for FIBRINOGEN; VON WILLEBRAND FACTOR; FIBRONECTIN; VITRONECTIN; and THROMBOSPONDINS. A deficiency of GPIIb-IIIa results in GLANZMANN THROMBASTHENIA.
Entry Version: GPIIB IIIA
Entry Term(s): GPIIb-IIIa Receptors; Glycoproteins IIb-IIIa; Integrin alpha-IIb beta-3; Integrin alphaIIbbeta3
Previous Indexing: Integrins (1992-1995); Platelet Membrane Glycoproteins (1987-1995)
See Also: Thrombasthenia
Public MeSH Note: 1996; see PLATELET MEMBRANE GLYCOPROTEINS 1987-95; INTEGRIN ALPHAIIBBETA3 was indexed under INTEGRINS 1992-95
History Note: 1996(1987); use INTEGRIN ALPHAIIBBETA3 (NM) 1992-1995
Entry Combination: deficiency:Thrombasthenia
Date Established: 1996/01/01
Date of Entry: 1995/05/26
Revision Date: 2023/03/16

Entry Combination: deficiency:Thrombasthenia
Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analogs & derivatives (AA)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M0028424
Scope Note: Platelet membrane glycoprotein complex important for platelet adhesion and aggregation. It is an integrin complex containing INTEGRIN ALPHAIIB and INTEGRIN BETA3 which recognizes the arginine-glycine-aspartic acid (RGD) sequence present on several adhesive proteins. As such, it is a receptor for FIBRINOGEN; VON WILLEBRAND FACTOR; FIBRONECTIN; VITRONECTIN; and THROMBOSPONDINS. A deficiency of GPIIb-IIIa results in GLANZMANN THROMBASTHENIA.
Terms: Platelet Glycoprotein GPIIb-IIIa Complex Preferred Term
Term UI T056830
Date01/01/1999
LexicalTag ACX
ThesaurusID NLM (1996); Integrin alpha-IIb beta-3
Term UI T056829
Date01/20/1995
LexicalTag NON
ThesaurusID NLM (1996); Glycoproteins IIb-IIIa
Term UI T056826
Date01/20/1995
LexicalTag NON
ThesaurusID NLM (1996); Integrin alphaIIbbeta3
Term UI T056827
Date04/19/1995
LexicalTag NON
ThesaurusID NLM (1996); GPIIb-IIIa Receptors
Term UI T056828
Date01/20/1995
LexicalTag NON
ThesaurusID NLM (1996)

Platelet Glycoprotein GPIIb-IIIa Complex MeSH Descriptor Data 2025