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Platelet Glycoprotein GPIIb-IIIa Complex MeSH Descriptor Data 2023


MeSH Heading
Platelet Glycoprotein GPIIb-IIIa Complex
Tree Number(s)
D12.776.395.550.625.785
D12.776.543.550.625.785
D12.776.543.750.705.408.460.700
D12.776.543.750.705.675.784
Unique ID
D019039
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D019039
Scope Note
Platelet membrane glycoprotein complex important for platelet adhesion and aggregation. It is an integrin complex containing INTEGRIN ALPHAIIB and INTEGRIN BETA3 which recognizes the arginine-glycine-aspartic acid (RGD) sequence present on several adhesive proteins. As such, it is a receptor for FIBRINOGEN; VON WILLEBRAND FACTOR; FIBRONECTIN; VITRONECTIN; and THROMBOSPONDINS. A deficiency of GPIIb-IIIa results in GLANZMANN THROMBASTHENIA.
Entry Version
GPIIB IIIA
Entry Term(s)
GPIIb-IIIa Receptors
Glycoproteins IIb-IIIa
Integrin alpha-IIb beta-3
Integrin alphaIIbbeta3
Registry Number
0
Previous Indexing
Integrins (1992-1995)
Platelet Membrane Glycoproteins (1987-1995)
See Also
Thrombasthenia
Public MeSH Note
1996; see PLATELET MEMBRANE GLYCOPROTEINS 1987-95; INTEGRIN ALPHAIIBBETA3 was indexed under INTEGRINS 1992-95
History Note
1996(1987); use INTEGRIN ALPHAIIBBETA3 (NM) 1992-1995
Entry Combination
deficiency:Thrombasthenia
Date Established
1996/01/01
Date of Entry
1995/05/26
Revision Date
2013/07/09
Platelet Glycoprotein GPIIb-IIIa Complex Preferred
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