MeSH Browser

MeSH Heading: Integrin alpha6beta1
Tree Number(s): D09.400.430.890.625.419; D12.776.395.550.625.419; D12.776.543.550.625.419; D12.776.543.750.705.408.850.674; D12.776.543.750.705.675.514; D12.776.543.750.705.876.500
Unique ID: D039121
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D039121
Scope Note: A cell surface receptor mediating cell adhesion to the EXTRACELLULAR MATRIX and to other cells via binding to LAMININ. It is involved in cell migration, embryonic development, leukocyte activation and tumor cell invasiveness. Integrin alpha6beta1 is the major laminin receptor on PLATELETS; LEUKOCYTES; and many EPITHELIAL CELLS, and ligand binding may activate a number of signal transduction pathways. Alternative splicing of the cytoplasmic domain of the alpha6 subunit (INTEGRIN ALPHA6) results in the formation of A and B isoforms of the heterodimer, which are expressed in a tissue-specific manner.
Entry Term(s): CD49f-CD29; Integrin alpha(6)beta(1); Integrin alpha6Abeta1; Integrin alpha6Bbeta1; Platelet Glycoprotein I'c-IIa; VLA-6; alpha 6 beta 1 Integrin; alpha6beta1 Integrin
Previous Indexing: Integrins (1992-2002)
Public MeSH Note: 2003; INTEGRIN ALPHA5BETA1 was indexed under INTEGRINS 1992-2002
History Note: 2003; use INTEGRIN ALPHA6BETA1 (NM) 1992-2002
Date Established: 2003/01/01
Date of Entry: 2002/07/02
Revision Date: 2023/03/16

Allowable Qualifiers: administration & dosage (AD)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

physiology (PH)

radiation effects (RE)

therapeutic use (TU)

ultrastructure (UL)

Carbohydrates [D09]
- Glycoconjugates [D09.400]
  - Glycoproteins [D09.400.430]
    - Membrane Glycoproteins [D09.400.430.890]
      - Platelet Membrane Glycoproteins [D09.400.430.890.625]
        
        CD36 Antigens [D09.400.430.890.625.136]
        
        Integrin alpha2beta1 [D09.400.430.890.625.298]
        
        Integrin alpha5beta1 [D09.400.430.890.625.379]
        
        Integrin alpha6beta1 [D09.400.430.890.625.419]
        
        Integrin alphaVbeta3 [D09.400.430.890.625.439]
        
        Lysosomal-Associated Membrane Protein 1 [D09.400.430.890.625.449]
        
        Platelet Glycoprotein GPIb-IX Complex [D09.400.430.890.625.460]
        
        Platelet Glycoprotein GPIIb-IIIa Complex [D09.400.430.890.625.785]
        
        Receptors, Thrombin [D09.400.430.890.625.800]
        
        P-Selectin [D09.400.430.890.625.905]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Glycoproteins [D12.776.395]
    - Membrane Glycoproteins [D12.776.395.550]
      - Platelet Membrane Glycoproteins [D12.776.395.550.625]
        
        CD36 Antigens [D12.776.395.550.625.136]
        
        Integrin alpha2beta1 [D12.776.395.550.625.298]
        
        Integrin alpha5beta1 [D12.776.395.550.625.379]
        
        Integrin alpha6beta1 [D12.776.395.550.625.419]
        
        Integrin alphaVbeta3 [D12.776.395.550.625.439]
        
        Lysosomal-Associated Membrane Protein 1 [D12.776.395.550.625.449]
        
        Platelet Glycoprotein GPIb-IX Complex [D12.776.395.550.625.460]
        
        Platelet Glycoprotein GPIIb-IIIa Complex [D12.776.395.550.625.785]
        
        Receptors, Thrombin [D12.776.395.550.625.800]
        
        P-Selectin [D12.776.395.550.625.905]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Membrane Proteins [D12.776.543]
    - Membrane Glycoproteins [D12.776.543.550]
      - Platelet Membrane Glycoproteins [D12.776.543.550.625]
        
        CD36 Antigens [D12.776.543.550.625.136]
        
        Integrin alpha2beta1 [D12.776.543.550.625.298]
        
        Integrin alpha5beta1 [D12.776.543.550.625.379]
        
        Integrin alpha6beta1 [D12.776.543.550.625.419]
        
        Integrin alphaVbeta3 [D12.776.543.550.625.439]
        
        Lysosomal-Associated Membrane Protein 1 [D12.776.543.550.625.449]
        
        Platelet Glycoprotein GPIb-IX Complex [D12.776.543.550.625.460]
        
        Platelet Glycoprotein GPIIb-IIIa Complex [D12.776.543.550.625.785]
        
        Receptors, Thrombin [D12.776.543.550.625.800]
        
        P-Selectin [D12.776.543.550.625.905]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Membrane Proteins [D12.776.543]
    - Receptors, Cell Surface [D12.776.543.750]
      - Receptors, Immunologic [D12.776.543.750.705]
        
        Integrins [D12.776.543.750.705.408]
        
        Receptors, Very Late Antigen [D12.776.543.750.705.408.850]
        
        Integrin alpha1beta1 [D12.776.543.750.705.408.850.099]
        
        Integrin alpha2beta1 [D12.776.543.750.705.408.850.199]
        
        Integrin alpha3beta1 [D12.776.543.750.705.408.850.249]
        
        Integrin alpha4beta1 [D12.776.543.750.705.408.850.299]
        
        Integrin alpha5beta1 [D12.776.543.750.705.408.850.349]
        
        Integrin alpha6beta1 [D12.776.543.750.705.408.850.674]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Membrane Proteins [D12.776.543]
    - Receptors, Cell Surface [D12.776.543.750]
      - Receptors, Immunologic [D12.776.543.750.705]
        
        Platelet Membrane Glycoproteins [D12.776.543.750.705.675]
        
        CD36 Antigens [D12.776.543.750.705.675.136]
        
        Integrin alpha2beta1 [D12.776.543.750.705.675.352]
        
        Integrin alpha5beta1 [D12.776.543.750.705.675.460]
        
        Integrin alpha6beta1 [D12.776.543.750.705.675.514]
        
        Integrin alphaVbeta3 [D12.776.543.750.705.675.541]
        
        Lysosomal-Associated Membrane Protein 1 [D12.776.543.750.705.675.554]
        
        Platelet Glycoprotein GPIb-IX Complex [D12.776.543.750.705.675.568]
        
        Platelet Glycoprotein GPIIb-IIIa Complex [D12.776.543.750.705.675.784]
        
        Receptors, Thrombin [D12.776.543.750.705.675.892]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Membrane Proteins [D12.776.543]
    - Receptors, Cell Surface [D12.776.543.750]
      - Receptors, Immunologic [D12.776.543.750.705]
        
        Receptors, Laminin [D12.776.543.750.705.876]
        
        Integrin alpha1beta1 [D12.776.543.750.705.876.249]
        
        Integrin alpha2beta1 [D12.776.543.750.705.876.280]
        
        Integrin alpha3beta1 [D12.776.543.750.705.876.311]
        
        Integrin alpha5beta1 [D12.776.543.750.705.876.374]
        
        Integrin alpha6beta1 [D12.776.543.750.705.876.500]
        
        Integrin alpha6beta4 [D12.776.543.750.705.876.750]

Integrin alpha6beta1 Preferred

Concept UI: M0208151
Scope Note: A cell surface receptor mediating cell adhesion to the EXTRACELLULAR MATRIX and to other cells via binding to LAMININ. It is involved in cell migration, embryonic development, leukocyte activation and tumor cell invasiveness. Integrin alpha6beta1 is the major laminin receptor on PLATELETS; LEUKOCYTES; and many EPITHELIAL CELLS, and ligand binding may activate a number of signal transduction pathways. Alternative splicing of the cytoplasmic domain of the alpha6 subunit (INTEGRIN ALPHA6) results in the formation of A and B isoforms of the heterodimer, which are expressed in a tissue-specific manner.
Terms: Integrin alpha6beta1 Preferred Term
Term UI T238156
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2003); VLA-6
Term UI T238150
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2003); alpha 6 beta 1 Integrin
Term UI T238151
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2003); CD49f-CD29
Term UI T238149
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2003); Integrin alpha(6)beta(1)
Term UI T238153
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2003); Platelet Glycoprotein I'c-IIa
Term UI T488230
Date04/01/2002
LexicalTag NON
ThesaurusID NLM (2003); alpha6beta1 Integrin
Term UI T238152
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2003)

Integrin alpha6Abeta1 Narrower

Integrin alpha6Bbeta1 Narrower

Integrin alpha6beta1 MeSH Descriptor Data 2025