MeSH Browser

MeSH Heading: Integrin alpha4beta1
Tree Number(s): D09.400.430.890.200.625.347; D12.776.395.550.200.625.347; D12.776.543.550.200.625.347; D12.776.543.750.705.408.530.500; D12.776.543.750.705.408.850.299; D12.776.543.750.705.877.347; D23.050.301.350.625.347
Unique ID: D039041
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D039041
Scope Note: Integrin alpha4beta1 is a FIBRONECTIN and VCAM-1 receptor present on LYMPHOCYTES; MONOCYTES; EOSINOPHILS; NK CELLS and thymocytes. It is involved in both cell-cell and cell- EXTRACELLULAR MATRIX adhesion and plays a role in INFLAMMATION, hematopoietic cell homing and immune function, and has been implicated in skeletal MYOGENESIS; NEURAL CREST migration and proliferation, lymphocyte maturation and morphogenesis of the PLACENTA and HEART.
Entry Term(s): CD49d-CD29; Integrin Heterodimer alpha4beta1; Integrin alpha(4)beta(1); VLA-4; Very Late Activation Antigen-4; Very Late Antigen-4; alpha4beta1 Integrin
Previous Indexing: Integrins (1991-2002); Receptors, Lymphocyte Homing (1991-2002)
Public MeSH Note: 2003; INTEGRIN ALPHA4BETA1 was indexed under INTEGRINS and RECEPTORS, LYMPHOCYTE HOMING 1991-2002
History Note: 2003 (1991)
Date Established: 2003/01/01
Date of Entry: 2002/07/02
Revision Date: 2023/03/16

Allowable Qualifiers: administration & dosage (AD)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

physiology (PH)

radiation effects (RE)

therapeutic use (TU)

ultrastructure (UL)

Concept UI: M0184906
Scope Note: Integrin alpha4beta1 is a FIBRONECTIN and VCAM-1 receptor present on LYMPHOCYTES; MONOCYTES; EOSINOPHILS; NK CELLS and thymocytes. It is involved in both cell-cell and cell- EXTRACELLULAR MATRIX adhesion and plays a role in INFLAMMATION, hematopoietic cell homing and immune function, and has been implicated in skeletal MYOGENESIS; NEURAL CREST migration and proliferation, lymphocyte maturation and morphogenesis of the PLACENTA and HEART.
Terms: Integrin alpha4beta1 Preferred Term
Term UI T214911
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2003); VLA-4
Term UI T214906
Date01/01/1955
LexicalTag ACR
ThesaurusID NLM (2003); Integrin alpha(4)beta(1)
Term UI T214907
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2003); Integrin Heterodimer alpha4beta1
Term UI T214908
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2003); CD49d-CD29
Term UI T214905
Date01/01/1955
LexicalTag ACR
ThesaurusID NLM (2003); Very Late Antigen-4
Term UI T214910
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2003); alpha4beta1 Integrin
Term UI T474410
Date12/19/2001
LexicalTag NON
ThesaurusID NLM (2003); Very Late Activation Antigen-4
Term UI T214909
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2003)

Integrin alpha4beta1 MeSH Descriptor Data 2025