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Lymphocyte Function-Associated Antigen-1 MeSH Descriptor Data 2022


MeSH Heading
Lymphocyte Function-Associated Antigen-1
Tree Number(s)
D12.776.395.550.200.074.937
D12.776.395.550.200.625.550
D12.776.543.550.200.093.937
D12.776.543.550.200.625.550
D12.776.543.750.705.408.600.400
D12.776.543.750.705.877.550
D23.050.301.350.074.400
D23.050.301.350.625.550
Unique ID
D016169
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D016169
Scope Note
An integrin heterodimer widely expressed on cells of hematopoietic origin. CD11A ANTIGEN comprises the alpha chain and the CD18 antigen (CD18 ANTIGENS) the beta chain. Lymphocyte function-associated antigen-1 is a major receptor of T-CELLS; B-CELLS; and GRANULOCYTES. It mediates the leukocyte adhesion reactions underlying cytolytic conjugate formation, helper T-cell interactions, and antibody-dependent killing by NATURAL KILLER CELLS and granulocytes. Intracellular adhesion molecule-1 has been defined as a ligand for lymphocyte function-associated antigen-1.
Entry Version
LFA1
Entry Term(s)
Integrin alphaLbeta2
LFA-1
Leukocyte Function Associated Antigen-1
Registry Number
0
Previous Indexing
Antigens, Differentiation (1988-1990)
Receptors, Leukocyte-Adhesion (1989-1990)
Public MeSH Note
1991
History Note
1991
Date Established
1991/01/01
Date of Entry
1990/04/24
Revision Date
2017/07/13
Lymphocyte Function-Associated Antigen-1 Preferred
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