MeSH Browser

MeSH Heading: Lymphocyte Function-Associated Antigen-1
Tree Number(s): D09.400.430.890.200.074.937; D09.400.430.890.200.625.550; D12.776.395.550.200.074.937; D12.776.395.550.200.625.550; D12.776.543.550.200.093.937; D12.776.543.550.200.625.550; D12.776.543.750.705.408.600.400; D12.776.543.750.705.877.550; D23.050.301.350.074.400; D23.050.301.350.625.550
Unique ID: D016169
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D016169
Scope Note: An integrin heterodimer widely expressed on cells of hematopoietic origin. CD11A ANTIGEN comprises the alpha chain and the CD18 antigen (CD18 ANTIGENS) the beta chain. Lymphocyte function-associated antigen-1 is a major receptor of T-CELLS; B-CELLS; and GRANULOCYTES. It mediates the leukocyte adhesion reactions underlying cytolytic conjugate formation, helper T-cell interactions, and antibody-dependent killing by NATURAL KILLER CELLS and granulocytes. Intracellular adhesion molecule-1 has been defined as a ligand for lymphocyte function-associated antigen-1.
Entry Version: LFA1
Entry Term(s): Integrin alphaLbeta2; LFA-1; Leukocyte Function Associated Antigen-1
Previous Indexing: Antigens, Differentiation (1988-1990); Receptors, Leukocyte-Adhesion (1989-1990)
Public MeSH Note: 1991
History Note: 1991
Date Established: 1991/01/01
Date of Entry: 1990/04/24
Revision Date: 2023/03/16

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemistry (CH)

classification (CL)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Carbohydrates [D09]
- Glycoconjugates [D09.400]
  - Glycoproteins [D09.400.430]
    - Membrane Glycoproteins [D09.400.430.890]
      - Cell Adhesion Molecules [D09.400.430.890.200]
        
        CD11 Antigens [D09.400.430.890.200.074]
        
        CD11a Antigen [D09.400.430.890.200.074.500]
        
        CD11b Antigen [D09.400.430.890.200.074.750]
        
        CD11c Antigen [D09.400.430.890.200.074.875]
        
        Lymphocyte Function-Associated Antigen-1 [D09.400.430.890.200.074.937]

Carbohydrates [D09]
- Glycoconjugates [D09.400]
  - Glycoproteins [D09.400.430]
    - Membrane Glycoproteins [D09.400.430.890]
      - Cell Adhesion Molecules [D09.400.430.890.200]
        
        Receptors, Lymphocyte Homing [D09.400.430.890.200.625]
        
        Hyaluronan Receptors [D09.400.430.890.200.625.144]
        
        Integrin alpha4beta1 [D09.400.430.890.200.625.347]
        
        Lymphocyte Function-Associated Antigen-1 [D09.400.430.890.200.625.550]
        
        L-Selectin [D09.400.430.890.200.625.903]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Glycoproteins [D12.776.395]
    - Membrane Glycoproteins [D12.776.395.550]
      - Cell Adhesion Molecules [D12.776.395.550.200]
        
        CD11 Antigens [D12.776.395.550.200.074]
        
        CD11a Antigen [D12.776.395.550.200.074.500]
        
        CD11b Antigen [D12.776.395.550.200.074.750]
        
        CD11c Antigen [D12.776.395.550.200.074.875]
        
        Lymphocyte Function-Associated Antigen-1 [D12.776.395.550.200.074.937]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Glycoproteins [D12.776.395]
    - Membrane Glycoproteins [D12.776.395.550]
      - Cell Adhesion Molecules [D12.776.395.550.200]
        
        Receptors, Lymphocyte Homing [D12.776.395.550.200.625]
        
        Hyaluronan Receptors [D12.776.395.550.200.625.144]
        
        Integrin alpha4beta1 [D12.776.395.550.200.625.347]
        
        Lymphocyte Function-Associated Antigen-1 [D12.776.395.550.200.625.550]
        
        L-Selectin [D12.776.395.550.200.625.903]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Membrane Proteins [D12.776.543]
    - Membrane Glycoproteins [D12.776.543.550]
      - Cell Adhesion Molecules [D12.776.543.550.200]
        
        CD11 Antigens [D12.776.543.550.200.093]
        
        CD11a Antigen [D12.776.543.550.200.093.500]
        
        CD11b Antigen [D12.776.543.550.200.093.750]
        
        CD11c Antigen [D12.776.543.550.200.093.875]
        
        Lymphocyte Function-Associated Antigen-1 [D12.776.543.550.200.093.937]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Membrane Proteins [D12.776.543]
    - Membrane Glycoproteins [D12.776.543.550]
      - Cell Adhesion Molecules [D12.776.543.550.200]
        
        Receptors, Lymphocyte Homing [D12.776.543.550.200.625]
        
        Hyaluronan Receptors [D12.776.543.550.200.625.144]
        
        Integrin alpha4beta1 [D12.776.543.550.200.625.347]
        
        Lymphocyte Function-Associated Antigen-1 [D12.776.543.550.200.625.550]
        
        L-Selectin [D12.776.543.550.200.625.903]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Membrane Proteins [D12.776.543]
    - Receptors, Cell Surface [D12.776.543.750]
      - Receptors, Immunologic [D12.776.543.750.705]
        
        Integrins [D12.776.543.750.705.408]
        
        Receptors, Leukocyte-Adhesion [D12.776.543.750.705.408.600]
        
        Integrin alphaXbeta2 [D12.776.543.750.705.408.600.100]
        
        Lymphocyte Function-Associated Antigen-1 [D12.776.543.750.705.408.600.400]
        
        Macrophage-1 Antigen [D12.776.543.750.705.408.600.500]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Membrane Proteins [D12.776.543]
    - Receptors, Cell Surface [D12.776.543.750]
      - Receptors, Immunologic [D12.776.543.750.705]
        
        Receptors, Lymphocyte Homing [D12.776.543.750.705.877]
        
        Hyaluronan Receptors [D12.776.543.750.705.877.144]
        
        Integrin alpha4beta1 [D12.776.543.750.705.877.347]
        
        Lymphocyte Function-Associated Antigen-1 [D12.776.543.750.705.877.550]
        
        L-Selectin [D12.776.543.750.705.877.903]

Biological Factors [D23]
- Antigens [D23.050]
  - Antigens, Surface [D23.050.301]
    - Cell Adhesion Molecules [D23.050.301.350]
      - CD11 Antigens [D23.050.301.350.074]
        
        CD11a Antigen [D23.050.301.350.074.024]
        
        CD11b Antigen [D23.050.301.350.074.049]
        
        CD11c Antigen [D23.050.301.350.074.074]
        
        Lymphocyte Function-Associated Antigen-1 [D23.050.301.350.074.400]

Biological Factors [D23]
- Antigens [D23.050]
  - Antigens, Surface [D23.050.301]
    - Cell Adhesion Molecules [D23.050.301.350]
      - Receptors, Lymphocyte Homing [D23.050.301.350.625]
        
        Hyaluronan Receptors [D23.050.301.350.625.144]
        
        Integrin alpha4beta1 [D23.050.301.350.625.347]
        
        Lymphocyte Function-Associated Antigen-1 [D23.050.301.350.625.550]
        
        L-Selectin [D23.050.301.350.625.903]

Lymphocyte Function-Associated Antigen-1 Preferred

Concept UI: M0024683
Scope Note: An integrin heterodimer widely expressed on cells of hematopoietic origin. CD11A ANTIGEN comprises the alpha chain and the CD18 antigen (CD18 ANTIGENS) the beta chain. Lymphocyte function-associated antigen-1 is a major receptor of T-CELLS; B-CELLS; and GRANULOCYTES. It mediates the leukocyte adhesion reactions underlying cytolytic conjugate formation, helper T-cell interactions, and antibody-dependent killing by NATURAL KILLER CELLS and granulocytes. Intracellular adhesion molecule-1 has been defined as a ligand for lymphocyte function-associated antigen-1.
Terms: Lymphocyte Function-Associated Antigen-1 Preferred Term
Term UI T048011
Date01/01/1999
LexicalTag NON
ThesaurusID NLM (1991); Leukocyte Function Associated Antigen-1
Term UI T048009
Date02/12/1990
LexicalTag NON
ThesaurusID NLM (1991); LFA-1
Term UI T048010
Date02/12/1990
LexicalTag ABB
ThesaurusID NLM (1991); Integrin alphaLbeta2
Term UI T048012
Date03/21/1996
LexicalTag NON
ThesaurusID NLM (1997)

Lymphocyte Function-Associated Antigen-1 MeSH Descriptor Data 2025