MeSH Browser

MeSH Heading: Receptors, Leukocyte-Adhesion
Tree Number(s): D12.776.543.750.705.408.600
Unique ID: D016028
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D016028
Scope Note: Family of proteins associated with the capacity of LEUKOCYTES to adhere to each other and to certain substrata, e.g., the C3bi component of complement. Members of this family are the LYMPHOCYTE FUNCTION-ASSOCIATED ANTIGEN-1; (LFA-1), the MACROPHAGE-1 ANTIGEN; (Mac-1), and the INTEGRIN ALPHAXBETA2 or p150,95 leukocyte adhesion protein. They all share a common beta-subunit which is the CD18 antigen. All three of the above antigens are absent in inherited LEUKOCYTE-ADHESION DEFICIENCY SYNDROME, which is characterized by recurrent bacterial infections, impaired pus formation, and wound healing as well as abnormalities in a wide spectrum of adherence-dependent functions of granulocytes, monocytes, and lymphoid cells.
Entry Version: RECEPT LEUKOCYTE ADHESION
Entry Term(s): Leu-CAM Receptor Family; Leukocyte-Adhesion Receptor; Leukocyte-Adhesion Receptor Family; Leukocyte-Adhesion Receptors
Previous Indexing: Antigens (1966-1987); Antigens, Differentiation (1988-1989); Receptors, Cell Surface (1973-1989); Receptors, Immunologic (1980-1989)
See Also: Leukocyte-Adhesion Deficiency Syndrome
Public MeSH Note: 90
History Note: 90
Date Established: 1990/01/01
Date of Entry: 1989/07/07
Revision Date: 2003/07/09

Allowable Qualifiers: administration & dosage (AD)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

chemistry (CH)

classification (CL)

drug effects (DE)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

physiology (PH)

radiation effects (RE)

therapeutic use (TU)

ultrastructure (UL)

Concept UI: M0024505
Scope Note: Family of proteins associated with the capacity of LEUKOCYTES to adhere to each other and to certain substrata, e.g., the C3bi component of complement. Members of this family are the LYMPHOCYTE FUNCTION-ASSOCIATED ANTIGEN-1; (LFA-1), the MACROPHAGE-1 ANTIGEN; (Mac-1), and the INTEGRIN ALPHAXBETA2 or p150,95 leukocyte adhesion protein. They all share a common beta-subunit which is the CD18 antigen. All three of the above antigens are absent in inherited LEUKOCYTE-ADHESION DEFICIENCY SYNDROME, which is characterized by recurrent bacterial infections, impaired pus formation, and wound healing as well as abnormalities in a wide spectrum of adherence-dependent functions of granulocytes, monocytes, and lymphoid cells.
Terms: Receptors, Leukocyte-Adhesion Preferred Term
Term UI T047597
Date01/01/1999
LexicalTag NON
ThesaurusID NLM (1990); Leu-CAM Receptor Family
Term UI T047594
Date05/10/1989
LexicalTag NON
ThesaurusID NLM (1990); Leukocyte-Adhesion Receptor
Term UI T047595
Date03/15/1993
LexicalTag NON
ThesaurusID NLM (1994); Leukocyte-Adhesion Receptors
Term UI T047596
Date06/21/1989
LexicalTag NON
ThesaurusID NLM (1990); Leukocyte-Adhesion Receptor Family
Term UI T490160
Date04/18/2002
LexicalTag NON
ThesaurusID NLM (2003)

Receptors, Leukocyte-Adhesion MeSH Descriptor Data 2025