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Integrin alpha Chains MeSH Descriptor Data 2023


MeSH Heading
Integrin alpha Chains
Tree Number(s)
D12.776.543.750.705.408.100
Unique ID
D039001
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D039001
Scope Note
The alpha subunits of integrin heterodimers (INTEGRINS), which mediate ligand specificity. There are approximately 18 different alpha chains, exhibiting great sequence diversity; several chains are also spliced into alternative isoforms. They possess a long extracellular portion (1200 amino acids) containing a MIDAS (metal ion-dependent adhesion site) motif, and seven 60-amino acid tandem repeats, the last 4 of which form EF HAND MOTIFS. The intracellular portion is short with the exception of INTEGRIN ALPHA4.
Entry Term(s)
Integrin alpha Subunits
alpha Integrins
Registry Number
0
Previous Indexing
Integrins (1966-2002)
Public MeSH Note
2003
History Note
2003
Date Established
2003/01/01
Date of Entry
2002/07/02
Revision Date
2013/07/09
Integrin alpha Chains Preferred
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