MeSH Browser

MeSH Heading: Integrin alpha Chains
Tree Number(s): D12.776.543.750.705.408.100
Unique ID: D039001
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D039001
Scope Note: The alpha subunits of integrin heterodimers (INTEGRINS), which mediate ligand specificity. There are approximately 18 different alpha chains, exhibiting great sequence diversity; several chains are also spliced into alternative isoforms. They possess a long extracellular portion (1200 amino acids) containing a MIDAS (metal ion-dependent adhesion site) motif, and seven 60-amino acid tandem repeats, the last 4 of which form EF HAND MOTIFS. The intracellular portion is short with the exception of INTEGRIN ALPHA4.
Entry Term(s): Integrin alpha Subunits; alpha Integrins
Previous Indexing: Integrins (1966-2002)
Public MeSH Note: 2003
History Note: 2003
Date Established: 2003/01/01
Date of Entry: 2002/07/02
Revision Date: 2013/07/09

Allowable Qualifiers: administration & dosage (AD)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

physiology (PH)

radiation effects (RE)

therapeutic use (TU)

ultrastructure (UL)

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Membrane Proteins [D12.776.543]
    - Receptors, Cell Surface [D12.776.543.750]
      - Receptors, Immunologic [D12.776.543.750.705]
        
        Integrins [D12.776.543.750.705.408]
        
        Integrin alpha Chains [D12.776.543.750.705.408.100]
        
        CD11a Antigen [D12.776.543.750.705.408.100.100]
        
        CD11b Antigen [D12.776.543.750.705.408.100.150]
        
        CD11c Antigen [D12.776.543.750.705.408.100.200]
        
        Integrin alpha1 [D12.776.543.750.705.408.100.300]
        
        Integrin alpha2 [D12.776.543.750.705.408.100.350]
        
        Integrin alpha3 [D12.776.543.750.705.408.100.400]
        
        Integrin alpha4 [D12.776.543.750.705.408.100.450]
        
        Integrin alpha5 [D12.776.543.750.705.408.100.500]
        
        Integrin alpha6 [D12.776.543.750.705.408.100.550]
        
        Integrin alphaV [D12.776.543.750.705.408.100.900]
        
        Platelet Membrane Glycoprotein IIb [D12.776.543.750.705.408.100.950]
        
        Integrin beta Chains [D12.776.543.750.705.408.200]
        
        Receptors, Cytoadhesin [D12.776.543.750.705.408.460]
        
        Receptors, Fibrinogen [D12.776.543.750.705.408.495]
        
        Receptors, Fibronectin [D12.776.543.750.705.408.530]
        
        Receptors, Leukocyte-Adhesion [D12.776.543.750.705.408.600]
        
        Receptors, Very Late Antigen [D12.776.543.750.705.408.850]

Integrin alpha Chains Preferred

Concept UI: M0417909
Scope Note: The alpha subunits of integrin heterodimers (INTEGRINS), which mediate ligand specificity. There are approximately 18 different alpha chains, exhibiting great sequence diversity; several chains are also spliced into alternative isoforms. They possess a long extracellular portion (1200 amino acids) containing a MIDAS (metal ion-dependent adhesion site) motif, and seven 60-amino acid tandem repeats, the last 4 of which form EF HAND MOTIFS. The intracellular portion is short with the exception of INTEGRIN ALPHA4.
Terms: Integrin alpha Chains Preferred Term
Term UI T486340
Date03/18/2002
LexicalTag NON
ThesaurusID NLM (2003); Integrin alpha Subunits
Term UI T493845
Date05/15/2002
LexicalTag NON
ThesaurusID NLM (2003); alpha Integrins
Term UI T490021
Date04/18/2002
LexicalTag NON
ThesaurusID NLM (2003)

Integrin alpha Chains MeSH Descriptor Data 2025