MeSH Browser

MeSH Heading: Orexin Receptors
Tree Number(s): D12.776.543.750.695.023; D12.776.543.750.720.600.074; D12.776.543.750.750.555.074
Unique ID: D064446
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D064446
Scope Note: G-protein-coupled NEUROPEPTIDE RECEPTORS that have specificity for OREXINS and play a role in appetite control, and sleep-wake cycles. Two principle receptor types exist, each having a specificity for OREXIN A and OREXIN B peptide subtypes.
Entry Term(s): HCRT Receptor 1; HCRT Receptor 2; HCTR2 Protein; Hypocretin Receptor; Hypocretin Receptor 2; Hypocretin Receptors; Hypocretin Receptors 2; Hypocretin-1 Receptor; Hypocretin-2 Receptor; OX1 Receptor; OX1 Receptors; OX2 Receptor; OX2 Receptors; Orexin A Receptor; Orexin B Receptor; Orexin Receptor; Orexin Receptor 2; Orexin Receptor Type 1; Orexin Receptor Type 2; Orexin-A Receptor; Orexin-A Receptors; Orexin-B Receptor; Orexin-B Receptors; Receptor 2, Hypocretin; Receptor, Orexin-A; Receptor, Orexin-B
Public MeSH Note: 2014; was indexed under NEUROPEPTIDE RECEPTORS and G PROTEIN- COUPLED RECEPTORS 1998-2013.
History Note: 2014
Entry Combination: antagonists & inhibitors:Orexin Receptor Antagonists
Date Established: 2014/01/01
Date of Entry: 2013/07/08
Revision Date: 2020/05/27

Entry Combination: antagonists & inhibitors:Orexin Receptor Antagonists
Allowable Qualifiers: administration & dosage (AD)

agonists (AG)

analysis (AN)

biosynthesis (BI)

blood (BL)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

physiology (PH)

radiation effects (RE)

therapeutic use (TU)

ultrastructure (UL)

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Membrane Proteins [D12.776.543]
    - Receptors, Cell Surface [D12.776.543.750]
      - Receptors, G-Protein-Coupled [D12.776.543.750.695]
        
        Apelin Receptors [D12.776.543.750.695.006]
        
        Calcitonin Receptor-Like Protein [D12.776.543.750.695.011]
        
        Frizzled Receptors [D12.776.543.750.695.017]
        
        Glucagon-Like Peptide Receptors [D12.776.543.750.695.021]
        
        Receptors, Kisspeptin-1 [D12.776.543.750.695.022]
        
        Orexin Receptors [D12.776.543.750.695.023]
        
        Receptor, Anaphylatoxin C5a [D12.776.543.750.695.024]
        
        Receptor, PAR-2 [D12.776.543.750.695.035]
        
        Receptors, Adrenomedullin [D12.776.543.750.695.041]
        
        Receptors, Angiotensin [D12.776.543.750.695.047]
        
        Receptors, Bombesin [D12.776.543.750.695.070]
        
        Receptors, Bradykinin [D12.776.543.750.695.080]
        
        Receptors, Calcitonin [D12.776.543.750.695.100]
        
        Receptors, Calcitonin Gene-Related Peptide [D12.776.543.750.695.105]
        
        Receptors, Calcium-Sensing [D12.776.543.750.695.115]
        
        Receptors, Cannabinoid [D12.776.543.750.695.125]
        
        Receptors, Catecholamine [D12.776.543.750.695.150]
        
        Receptors, Chemokine [D12.776.543.750.695.160]
        
        Receptors, Cholecystokinin [D12.776.543.750.695.170]
        
        Receptors, Corticotropin-Releasing Hormone [D12.776.543.750.695.180]
        
        Receptors, Eicosanoid [D12.776.543.750.695.200]
        
        Receptors, Endothelin [D12.776.543.750.695.220]
        
        Receptors, Formyl Peptide [D12.776.543.750.695.235]
        
        Receptors, FSH [D12.776.543.750.695.250]
        
        Receptors, GABA-B [D12.776.543.750.695.300]
        
        Receptors, Galanin [D12.776.543.750.695.315]
        
        Receptors, Ghrelin [D12.776.543.750.695.322]
        
        Receptors, Glucagon [D12.776.543.750.695.330]
        
        Receptors, Histamine H1 [D12.776.543.750.695.350]
        
        Receptors, Histamine H2 [D12.776.543.750.695.355]
        
        Receptors, Histamine H4 [D12.776.543.750.695.358]
        
        Receptors, Islet Amyloid Polypeptide [D12.776.543.750.695.360]
        
        Receptors, LH [D12.776.543.750.695.400]
        
        Receptors, LHRH [D12.776.543.750.695.410]
        
        Receptors, Lysophospholipid [D12.776.543.750.695.420]
        
        Receptors, Melanocortin [D12.776.543.750.695.430]
        
        Receptors, Melatonin [D12.776.543.750.695.440]
        
        Receptors, Metabotropic Glutamate [D12.776.543.750.695.450]
        
        Receptors, Muscarinic [D12.776.543.750.695.475]
        
        Receptors, Neuropeptide Y [D12.776.543.750.695.500]
        
        Receptors, Neurotensin [D12.776.543.750.695.550]
        
        Receptors, Odorant [D12.776.543.750.695.600]
        
        Receptors, Opioid [D12.776.543.750.695.620]
        
        Receptors, Oxytocin [D12.776.543.750.695.630]
        
        Receptors, Parathyroid Hormone [D12.776.543.750.695.650]
        
        Receptors, Pheromone [D12.776.543.750.695.660]
        
        Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide [D12.776.543.750.695.665]
        
        Receptors, Purinergic [D12.776.543.750.695.700]
        
        Receptors, Serotonin [D12.776.543.750.695.800]
        
        Receptors, Somatostatin [D12.776.543.750.695.850]
        
        Receptors, Tachykinin [D12.776.543.750.695.862]
        
        Receptors, Thrombin [D12.776.543.750.695.875]
        
        Receptors, Vasopressin [D12.776.543.750.695.910]
        
        Rhodopsin [D12.776.543.750.695.955]
        
        Taste Receptors, Type 2 [D12.776.543.750.695.966]
        
        Xenotropic and Polytropic Retrovirus Receptor [D12.776.543.750.695.977]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Membrane Proteins [D12.776.543]
    - Receptors, Cell Surface [D12.776.543.750]
      - Receptors, Neurotransmitter [D12.776.543.750.720]
        
        Receptors, Neuropeptide [D12.776.543.750.720.600]
        
        Orexin Receptors [D12.776.543.750.720.600.074]
        
        Receptors, Bombesin [D12.776.543.750.720.600.200]
        
        Receptors, Bradykinin [D12.776.543.750.720.600.220]
        
        Receptors, Calcitonin Gene-Related Peptide [D12.776.543.750.720.600.260]
        
        Receptors, Cholecystokinin [D12.776.543.750.720.600.270]
        
        Receptors, Corticotropin [D12.776.543.750.720.600.285]
        
        Receptors, Corticotropin-Releasing Hormone [D12.776.543.750.720.600.290]
        
        Receptors, FSH [D12.776.543.750.720.600.370]
        
        Receptors, Galanin [D12.776.543.750.720.600.410]
        
        Receptors, LH [D12.776.543.750.720.600.450]
        
        Receptors, LHRH [D12.776.543.750.720.600.460]
        
        Receptors, Neuropeptide Y [D12.776.543.750.720.600.540]
        
        Receptors, Neurotensin [D12.776.543.750.720.600.560]
        
        Receptors, Opioid [D12.776.543.750.720.600.610]
        
        Receptors, Oxytocin [D12.776.543.750.720.600.630]
        
        Receptors, Prolactin [D12.776.543.750.720.600.710]
        
        Receptors, Somatostatin [D12.776.543.750.720.600.760]
        
        Receptors, Tachykinin [D12.776.543.750.720.600.830]
        
        Receptors, Thyrotropin [D12.776.543.750.720.600.850]
        
        Receptors, Thyrotropin-Releasing Hormone [D12.776.543.750.720.600.860]
        
        Receptors, Vasoactive Intestinal Peptide [D12.776.543.750.720.600.915]
        
        Receptors, Vasopressin [D12.776.543.750.720.600.925]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Membrane Proteins [D12.776.543]
    - Receptors, Cell Surface [D12.776.543.750]
      - Receptors, Peptide [D12.776.543.750.750]
        
        Receptors, Neuropeptide [D12.776.543.750.750.555]
        
        Orexin Receptors [D12.776.543.750.750.555.074]
        
        Receptors, Bombesin [D12.776.543.750.750.555.200]
        
        Receptors, Bradykinin [D12.776.543.750.750.555.220]
        
        Receptors, Calcitonin Gene-Related Peptide [D12.776.543.750.750.555.260]
        
        Receptors, Cholecystokinin [D12.776.543.750.750.555.270]
        
        Receptors, Corticotropin [D12.776.543.750.750.555.285]
        
        Receptors, Corticotropin-Releasing Hormone [D12.776.543.750.750.555.290]
        
        Receptors, FSH [D12.776.543.750.750.555.370]
        
        Receptors, Galanin [D12.776.543.750.750.555.410]
        
        Receptors, LH [D12.776.543.750.750.555.450]
        
        Receptors, LHRH [D12.776.543.750.750.555.460]
        
        Receptors, Neuropeptide Y [D12.776.543.750.750.555.540]
        
        Receptors, Neurotensin [D12.776.543.750.750.555.560]
        
        Receptors, Opioid [D12.776.543.750.750.555.610]
        
        Receptors, Oxytocin [D12.776.543.750.750.555.630]
        
        Receptors, Prolactin [D12.776.543.750.750.555.710]
        
        Receptors, Somatostatin [D12.776.543.750.750.555.760]
        
        Receptors, Somatotropin [D12.776.543.750.750.555.770]
        
        Receptors, Tachykinin [D12.776.543.750.750.555.830]
        
        Receptors, Thyrotropin [D12.776.543.750.750.555.850]
        
        Receptors, Thyrotropin-Releasing Hormone [D12.776.543.750.750.555.860]
        
        Receptors, Vasoactive Intestinal Peptide [D12.776.543.750.750.555.915]
        
        Receptors, Vasopressin [D12.776.543.750.750.555.925]

Orexin Receptors Preferred

Concept UI: M0498565
Scope Note: G-protein-coupled NEUROPEPTIDE RECEPTORS that have specificity for OREXINS and play a role in appetite control, and sleep-wake cycles. Two principle receptor types exist, each having a specificity for OREXIN A and OREXIN B peptide subtypes.
Terms: Orexin Receptors Preferred Term
Term UI T838104
Date03/04/2013
LexicalTag NON
ThesaurusID NLM (2014); Hypocretin Receptor
Term UI T000997322
Date11/18/2019
LexicalTag NON
ThesaurusID NLM (2021); Orexin Receptor
Term UI T000997321
Date11/18/2019
LexicalTag NON
ThesaurusID NLM (2021); Hypocretin Receptors
Term UI T000877292
Date03/24/2015
LexicalTag NON
ThesaurusID NLM (2016)

Orexin A Receptor Narrower

Concept UI: M0581946
Terms: Orexin A Receptor Preferred Term
Term UI T838105
Date03/04/2013
LexicalTag NON
ThesaurusID NLM (2014); Receptor, Orexin-A
Term UI T838107
Date03/04/2013
LexicalTag NON
ThesaurusID NLM (2014); Orexin-A Receptor
Term UI T838111
Date03/04/2013
LexicalTag NON
ThesaurusID NLM (2014); Orexin-A Receptors
Term UI T838112
Date03/04/2013
LexicalTag NON
ThesaurusID NLM (2014); Orexin Receptor Type 1
Term UI T838121
Date03/04/2013
LexicalTag NON
ThesaurusID NLM (2014); HCRT Receptor 1
Term UI T838122
Date03/04/2013
LexicalTag ABX
ThesaurusID NLM (2014); Hypocretin-1 Receptor
Term UI T838123
Date03/04/2013
LexicalTag NON
ThesaurusID NLM (2014); OX1 Receptor
Term UI T000997323
Date11/18/2019
LexicalTag NON
ThesaurusID NLM (2021); OX1 Receptors
Term UI T000879006
Date04/30/2015
LexicalTag ABX
ThesaurusID NLM (2016)

Orexin B Receptor Narrower

Concept UI: M0581947
Terms: Orexin B Receptor Preferred Term
Term UI T838110
Date03/04/2013
LexicalTag NON
ThesaurusID NLM (2014); Receptor, Orexin-B
Term UI T838106
Date03/04/2013
LexicalTag NON
ThesaurusID NLM (2014); Orexin-B Receptors
Term UI T838108
Date03/04/2013
LexicalTag NON
ThesaurusID NLM (2014); Orexin-B Receptor
Term UI T838113
Date03/04/2013
LexicalTag NON
ThesaurusID NLM (2014); Orexin Receptor Type 2
Term UI T838124
Date03/04/2013
LexicalTag NON
ThesaurusID NLM (2014); HCRT Receptor 2
Term UI T838125
Date03/04/2013
LexicalTag NON
ThesaurusID NLM (2014); HCTR2 Protein
Term UI T838127
Date03/04/2013
LexicalTag ABX
ThesaurusID NLM (2014); Hypocretin Receptor 2
Term UI T838128
Date03/04/2013
LexicalTag NON
ThesaurusID NLM (2014); Orexin Receptor 2
Term UI T838129
Date03/04/2013
LexicalTag NON
ThesaurusID NLM (2014); Hypocretin Receptors 2
Term UI T838130
Date03/04/2013
LexicalTag NON
ThesaurusID NLM (2014); Hypocretin-2 Receptor
Term UI T838131
Date03/04/2013
LexicalTag NON
ThesaurusID NLM (2014); Receptor 2, Hypocretin
Term UI T838132
Date03/04/2013
LexicalTag NON
ThesaurusID NLM (2014); OX2 Receptors
Term UI T000879007
Date04/30/2015
LexicalTag ABX
ThesaurusID NLM (2016); OX2 Receptor
Term UI T000997324
Date11/18/2019
LexicalTag NON
ThesaurusID NLM (2021)

Orexin Receptors MeSH Descriptor Data 2025