MeSH Browser

MeSH Heading: Receptor, Fibroblast Growth Factor, Type 2
Tree Number(s): D08.811.913.696.620.682.725.400.178; D12.776.476.568.400.178; D12.776.543.750.630.441; D12.776.543.750.750.400.370.750
Unique ID: D051497
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D051497
Scope Note: A fibroblast growth factor receptor which contains three extracellular IMMUNOGLOBULIN I-SET DOMAINS and is expressed as two isoforms. One receptor isoform is expressed in the MESENCHYME and is activated by FIBROBLAST GROWTH FACTOR 2. A second isoform is expressed mainly by EPITHELIAL CELLS and is activated by FIBROBLAST GROWTH FACTOR 7 and FIBROBLAST GROWTH FACTOR 10. Mutation of the gene for fibroblast growth factor receptor 2 can result in craniosynostotic syndromes (e.g., APERT SYNDROME; and CROUZON SYNDROME).
Entry Term(s): BEK Fibroblast Growth Factor Receptor; BEK Fibroblast Growth Factor Receptor Kinase; BEK Protein Tyrosine Kinase; Bek Fgf Receptor Kinase; Bek-Related Fibroblast Growth Factor-Receptor-1; CD332 Antigen; FGFR2 Protein; FGFR2b; FGFR2c; Fibroblast Growth Factor Receptor 2; Fibroblast Growth Factor Receptor 2b; Fibroblast Growth Factor Receptor 2c; Fibroblast Growth Factor Receptors 2; Fibroblast Growth Factor Receptors 2b; Receptor, Fibroblast Growth Factor 2b; Receptor, Fibroblast Growth Factor 2c
Registry Numbers: EC 2.7.10.1; EC 2.7.10.1; EC 2.7.10.1
Related Numbers: EC 2.7.10.1
See Also: Acrocephalosyndactylia; Antley-Bixler Syndrome Phenotype; Craniofacial Dysostosis
Public MeSH Note: 2006; FIBROBLAST GROWTH FACTOR RECEPTOR 2 was indexed under RECEPTORS, FIBROBLAST GROWTH FACTOR & RECEPTOR PROTEIN-TYROSINE KINASE 2004-2005, & under PROTEIN-TYROSINE KINASE 1999-2003
History Note: 2006(1999)
Date Established: 2006/01/01
Date of Entry: 2005/06/30
Revision Date: 2021/05/21

Allowable Qualifiers: administration & dosage (AD)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

physiology (PH)

radiation effects (RE)

therapeutic use (TU)

ultrastructure (UL)

Enzymes and Coenzymes [D08]
- Enzymes [D08.811]
  - Transferases [D08.811.913]
    - Phosphotransferases [D08.811.913.696]
      - Phosphotransferases (Alcohol Group Acceptor) [D08.811.913.696.620]
        
        Protein Kinases [D08.811.913.696.620.682]
        
        Protein-Tyrosine Kinases [D08.811.913.696.620.682.725]
        
        Receptor Protein-Tyrosine Kinases [D08.811.913.696.620.682.725.400]
        
        Anaplastic Lymphoma Kinase [D08.811.913.696.620.682.725.400.002]
        
        c-Mer Tyrosine Kinase [D08.811.913.696.620.682.725.400.003]
        
        Discoidin Domain Receptors [D08.811.913.696.620.682.725.400.005]
        
        ErbB Receptors [D08.811.913.696.620.682.725.400.009]
        
        fms-Like Tyrosine Kinase 3 [D08.811.913.696.620.682.725.400.020]
        
        Proto-Oncogene Proteins c-kit [D08.811.913.696.620.682.725.400.050]
        
        Proto-Oncogene Proteins c-met [D08.811.913.696.620.682.725.400.075]
        
        Proto-Oncogene Proteins c-ret [D08.811.913.696.620.682.725.400.087]
        
        Receptor Tyrosine Kinase-like Orphan Receptors [D08.811.913.696.620.682.725.400.093]
        
        Receptor, Fibroblast Growth Factor, Type 1 [D08.811.913.696.620.682.725.400.177]
        
        Receptor, Fibroblast Growth Factor, Type 2 [D08.811.913.696.620.682.725.400.178]
        
        Receptor, Fibroblast Growth Factor, Type 3 [D08.811.913.696.620.682.725.400.179]
        
        Receptor, Fibroblast Growth Factor, Type 4 [D08.811.913.696.620.682.725.400.180]
        
        Receptor, IGF Type 1 [D08.811.913.696.620.682.725.400.185]
        
        Receptor, Insulin [D08.811.913.696.620.682.725.400.200]
        
        Receptor, Macrophage Colony-Stimulating Factor [D08.811.913.696.620.682.725.400.500]
        
        Receptor, trkA [D08.811.913.696.620.682.725.400.660]
        
        Receptor, trkB [D08.811.913.696.620.682.725.400.700]
        
        Receptor, trkC [D08.811.913.696.620.682.725.400.800]
        
        Receptors, Eph Family [D08.811.913.696.620.682.725.400.850]
        
        Receptors, Platelet-Derived Growth Factor [D08.811.913.696.620.682.725.400.900]
        
        Receptors, TIE [D08.811.913.696.620.682.725.400.925]
        
        Receptors, Vascular Endothelial Growth Factor [D08.811.913.696.620.682.725.400.950]
        
        Axl Receptor Tyrosine Kinase [D08.811.913.696.620.682.725.400.975]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Intracellular Signaling Peptides and Proteins [D12.776.476]
    - Protein-Tyrosine Kinases [D12.776.476.568]
      - Receptor Protein-Tyrosine Kinases [D12.776.476.568.400]
        
        Anaplastic Lymphoma Kinase [D12.776.476.568.400.002]
        
        c-Mer Tyrosine Kinase [D12.776.476.568.400.003]
        
        Discoidin Domain Receptors [D12.776.476.568.400.005]
        
        ErbB Receptors [D12.776.476.568.400.009]
        
        fms-Like Tyrosine Kinase 3 [D12.776.476.568.400.020]
        
        Proto-Oncogene Proteins c-kit [D12.776.476.568.400.050]
        
        Proto-Oncogene Proteins c-met [D12.776.476.568.400.075]
        
        Proto-Oncogene Proteins c-ret [D12.776.476.568.400.087]
        
        Receptor Tyrosine Kinase-like Orphan Receptors [D12.776.476.568.400.093]
        
        Receptor, Fibroblast Growth Factor, Type 1 [D12.776.476.568.400.177]
        
        Receptor, Fibroblast Growth Factor, Type 2 [D12.776.476.568.400.178]
        
        Receptor, Fibroblast Growth Factor, Type 3 [D12.776.476.568.400.179]
        
        Receptor, Fibroblast Growth Factor, Type 4 [D12.776.476.568.400.180]
        
        Receptor, IGF Type 1 [D12.776.476.568.400.185]
        
        Receptor, Insulin [D12.776.476.568.400.200]
        
        Receptor, Macrophage Colony-Stimulating Factor [D12.776.476.568.400.500]
        
        Receptor, trkA [D12.776.476.568.400.660]
        
        Receptor, trkB [D12.776.476.568.400.700]
        
        Receptor, trkC [D12.776.476.568.400.800]
        
        Receptors, Eph Family [D12.776.476.568.400.850]
        
        Receptors, Platelet-Derived Growth Factor [D12.776.476.568.400.900]
        
        Receptors, TIE [D12.776.476.568.400.925]
        
        Receptors, Vascular Endothelial Growth Factor [D12.776.476.568.400.950]
        
        Axl Receptor Tyrosine Kinase [D12.776.476.568.400.975]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Membrane Proteins [D12.776.543]
    - Receptors, Cell Surface [D12.776.543.750]
      - Receptor Protein-Tyrosine Kinases [D12.776.543.750.630]
        
        Anaplastic Lymphoma Kinase [D12.776.543.750.630.002]
        
        c-Mer Tyrosine Kinase [D12.776.543.750.630.003]
        
        Discoidin Domain Receptors [D12.776.543.750.630.005]
        
        ErbB Receptors [D12.776.543.750.630.009]
        
        fms-Like Tyrosine Kinase 3 [D12.776.543.750.630.020]
        
        Proto-Oncogene Proteins c-kit [D12.776.543.750.630.124]
        
        Proto-Oncogene Proteins c-met [D12.776.543.750.630.186]
        
        Proto-Oncogene Proteins c-ret [D12.776.543.750.630.217]
        
        Receptor Tyrosine Kinase-like Orphan Receptors [D12.776.543.750.630.233]
        
        Receptor, Fibroblast Growth Factor, Type 1 [D12.776.543.750.630.440]
        
        Receptor, Fibroblast Growth Factor, Type 2 [D12.776.543.750.630.441]
        
        Receptor, Fibroblast Growth Factor, Type 3 [D12.776.543.750.630.442]
        
        Receptor, Fibroblast Growth Factor, Type 4 [D12.776.543.750.630.443]
        
        Receptor, IGF Type 1 [D12.776.543.750.630.468]
        
        Receptor, Insulin [D12.776.543.750.630.484]
        
        Receptor, Macrophage Colony-Stimulating Factor [D12.776.543.750.630.492]
        
        Receptor, trkA [D12.776.543.750.630.496]
        
        Receptor, trkB [D12.776.543.750.630.498]
        
        Receptor, trkC [D12.776.543.750.630.499]
        
        Receptors, Eph Family [D12.776.543.750.630.500]
        
        Receptors, Platelet-Derived Growth Factor [D12.776.543.750.630.625]
        
        Receptors, TIE [D12.776.543.750.630.687]
        
        Receptors, Vascular Endothelial Growth Factor [D12.776.543.750.630.750]
        
        Axl Receptor Tyrosine Kinase [D12.776.543.750.630.875]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Membrane Proteins [D12.776.543]
    - Receptors, Cell Surface [D12.776.543.750]
      - Receptors, Peptide [D12.776.543.750.750]
        
        Receptors, Growth Factor [D12.776.543.750.750.400]
        
        Receptors, Fibroblast Growth Factor [D12.776.543.750.750.400.370]
        
        Klotho Proteins [D12.776.543.750.750.400.370.250]
        
        Receptor, Fibroblast Growth Factor, Type 1 [D12.776.543.750.750.400.370.500]
        
        Receptor, Fibroblast Growth Factor, Type 2 [D12.776.543.750.750.400.370.750]
        
        Receptor, Fibroblast Growth Factor, Type 3 [D12.776.543.750.750.400.370.875]
        
        Receptor, Fibroblast Growth Factor, Type 4 [D12.776.543.750.750.400.370.937]
        
        Receptor, Fibroblast Growth Factor, Type 5 [D12.776.543.750.750.400.370.968]

Receptor, Fibroblast Growth Factor, Type 2 Preferred

Fibroblast Growth Factor Receptor 2c Narrower

Fibroblast Growth Factor Receptor 2b Narrower

Receptor, Fibroblast Growth Factor, Type 2 MeSH Descriptor Data 2025