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Receptor, IGF Type 1 MeSH Descriptor Data 2023


MeSH Heading
Receptor, IGF Type 1
Tree Number(s)
D08.811.913.696.620.682.725.400.185
D12.776.476.568.400.185
D12.776.543.750.630.468
D12.776.543.750.750.400.780.400
Unique ID
D017526
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D017526
Scope Note
A protein-tyrosine kinase receptor that is closely related in structure to the INSULIN RECEPTOR. Although commonly referred to as the IGF-I receptor, it binds both IGF-I and IGF-II with high affinity. It is comprised of a tetramer of two alpha and two beta subunits which are derived from cleavage of a single precursor protein. The beta subunit contains an intrinsic tyrosine kinase domain.
Entry Version
RECEPT IGF TYPE 1
Entry Term(s)
IGF Type 1 Receptor
IGF-1 Receptor
IGF-I Receptor
Insulin-Like-Growth Factor I Receptor
Receptor, IGF Type 1 alpha Subunit
Receptor, IGF Type 1 beta Subunit
Receptor, IGF-I
Receptor, Insulin-Like Growth Factor I
Receptor, Insulin-Like Growth Factor Type 1
Receptors, IGF-1
Receptors, Insulin-Like-Growth Factor I
Registry Number
EC 2.7.10.1
Previous Indexing
Receptors, Endogenous Substances (1986-1992)
See Also
Insulin-Like Growth Factor I
Insulin-Like Growth Factor II
Public MeSH Note
2000; see RECEPTOR, INSULIN-LIKE-GROWTH FACTOR I 1993-1999
History Note
2000(1993);
Date Established
1993/01/01
Date of Entry
1992/05/29
Revision Date
2021/05/21
Receptor, IGF Type 1 Preferred
Receptor, IGF Type 1 beta Subunit Narrower
Receptor, IGF Type 1 alpha Subunit Narrower
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