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N-Myc Proto-Oncogene Protein MeSH Descriptor Data 2023


MeSH Heading
N-Myc Proto-Oncogene Protein
Tree Number(s)
D12.776.260.103.500.625
D12.776.260.108.092.625
D12.776.624.664.700.158
D12.776.930.125.500.563
D12.776.930.127.092.625
Unique ID
D000071447
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D000071447
Scope Note
A basic helix-loop-helix leucine zipper (bHLHZ) transcription factor and proto-oncogene protein that functions in cell growth and proliferation. In mammals, it is highly expressed in the brain during embryogenesis and is essential for brain development; it is not expressed in adult tissues. Amplification or overexpression of N-Myc occurs in at least 20% of tumors and is associated with a poor prognosis in cases of NEUROBLASTOMA; ALVEOLAR RHABDOMYOSARCOMA; SMALL CELL LUNG CARCINOMA; and neuroendocrine prostate cancer.
Entry Term(s)
BHLHE37 Protein
Class E Basic Helix-Loop-Helix Protein 37
MYCN Protein
N-Myc Protein
NMYC Protein
Registry Number
0
Previous Indexing
Nuclear Proteins (2002-2016)
Oncogene Proteins (2002-2016)
Proto-Oncogene Proteins (2012-2016)
Public MeSH Note
2017
History Note
2017
Date Established
2017/01/01
Date of Entry
2016/07/08
Revision Date
2016/04/15
N-Myc Proto-Oncogene Protein Preferred
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