MeSH Browser

MeSH Heading: N-Myc Proto-Oncogene Protein
Tree Number(s): D12.776.260.103.500.625; D12.776.260.108.092.625; D12.776.624.664.700.158; D12.776.930.125.500.563; D12.776.930.127.092.625
Unique ID: D000071447
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D000071447
Scope Note: A basic helix-loop-helix leucine zipper (bHLHZ) transcription factor and proto-oncogene protein that functions in cell growth and proliferation. In mammals, it is highly expressed in the brain during embryogenesis and is essential for brain development; it is not expressed in adult tissues. Amplification or overexpression of N-Myc occurs in at least 20% of tumors and is associated with a poor prognosis in cases of NEUROBLASTOMA; ALVEOLAR RHABDOMYOSARCOMA; SMALL CELL LUNG CARCINOMA; and neuroendocrine prostate cancer.
Entry Term(s): BHLHE37 Protein; Class E Basic Helix-Loop-Helix Protein 37; MYCN Protein; N-Myc Protein; NMYC Protein
Previous Indexing: Nuclear Proteins (2002-2016); Oncogene Proteins (2002-2016); Proto-Oncogene Proteins (2012-2016)
Public MeSH Note: 2017
History Note: 2017
Date Established: 2017/01/01
Date of Entry: 2016/07/08
Revision Date: 2016/04/15

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - DNA-Binding Proteins [D12.776.260]
    - Basic Helix-Loop-Helix Transcription Factors [D12.776.260.103]
      - Basic Helix-Loop-Helix Leucine Zipper Transcription Factors [D12.776.260.103.500]
        
        Microphthalmia-Associated Transcription Factor [D12.776.260.103.500.500]
        
        N-Myc Proto-Oncogene Protein [D12.776.260.103.500.625]
        
        Sterol Regulatory Element Binding Proteins [D12.776.260.103.500.750]
        
        Transcription Factor 3 [D12.776.260.103.500.875]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - DNA-Binding Proteins [D12.776.260]
    - Basic-Leucine Zipper Transcription Factors [D12.776.260.108]
      - Basic Helix-Loop-Helix Leucine Zipper Transcription Factors [D12.776.260.108.092]
        
        Microphthalmia-Associated Transcription Factor [D12.776.260.108.092.500]
        
        N-Myc Proto-Oncogene Protein [D12.776.260.108.092.625]
        
        Sterol Regulatory Element Binding Proteins [D12.776.260.108.092.750]
        
        Transcription Factor 3 [D12.776.260.108.092.875]
        
        Transcription Factor 4 [D12.776.260.108.092.937]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Neoplasm Proteins [D12.776.624]
    - Oncogene Proteins [D12.776.624.664]
      - Proto-Oncogene Proteins [D12.776.624.664.700]
        
        Axl Receptor Tyrosine Kinase [D12.776.624.664.700.013]
        
        Bcl-2-Like Protein 11 [D12.776.624.664.700.025]
        
        c-Mer Tyrosine Kinase [D12.776.624.664.700.037]
        
        Chemokine CXCL1 [D12.776.624.664.700.049]
        
        Cyclin D1 [D12.776.624.664.700.100]
        
        Fibroblast Growth Factor 4 [D12.776.624.664.700.110]
        
        Fibroblast Growth Factor 6 [D12.776.624.664.700.112]
        
        fms-Like Tyrosine Kinase 3 [D12.776.624.664.700.114]
        
        Janus Kinase 2 [D12.776.624.664.700.117]
        
        KRIT1 Protein [D12.776.624.664.700.119]
        
        Kruppel-Like Factor 6 [D12.776.624.664.700.120]
        
        Lipocalin-2 [D12.776.624.664.700.123]
        
        Lymphocyte Specific Protein Tyrosine Kinase p56(lck) [D12.776.624.664.700.128]
        
        MDS1 and EVI1 Complex Locus Protein [D12.776.624.664.700.129]
        
        MutS Homolog 2 Protein [D12.776.624.664.700.130]
        
        Myeloid-Lymphoid Leukemia Protein [D12.776.624.664.700.148]
        
        N-Myc Proto-Oncogene Protein [D12.776.624.664.700.158]
        
        Pre-B-Cell Leukemia Transcription Factor 1 [D12.776.624.664.700.163]
        
        B-Cell Lymphoma 3 Protein [D12.776.624.664.700.165]
        
        Proto-Oncogene Mas [D12.776.624.664.700.166]
        
        Proto-Oncogene Proteins c-abl [D12.776.624.664.700.167]
        
        Proto-Oncogene Proteins c-akt [D12.776.624.664.700.168]
        
        Proto-Oncogene Proteins c-bcl-2 [D12.776.624.664.700.169]
        
        Proto-Oncogene Proteins c-bcl-6 [D12.776.624.664.700.170]
        
        Proto-Oncogene Proteins c-bcr [D12.776.624.664.700.171]
        
        Proto-Oncogene Proteins c-cbl [D12.776.624.664.700.172]
        
        Proto-Oncogene Proteins c-crk [D12.776.624.664.700.174]
        
        Proto-Oncogene Proteins c-ets [D12.776.624.664.700.175]
        
        Proto-Oncogene Proteins c-fes [D12.776.624.664.700.177]
        
        Proto-Oncogene Proteins c-fos [D12.776.624.664.700.179]
        
        Proto-Oncogene Proteins c-fyn [D12.776.624.664.700.180]
        
        Proto-Oncogene Proteins c-hck [D12.776.624.664.700.181]
        
        Proto-Oncogene Proteins c-jun [D12.776.624.664.700.182]
        
        Proto-Oncogene Proteins c-kit [D12.776.624.664.700.183]
        
        Proto-Oncogene Proteins c-maf [D12.776.624.664.700.184]
        
        Proto-Oncogene Proteins c-mdm2 [D12.776.624.664.700.185]
        
        Proto-Oncogene Proteins c-met [D12.776.624.664.700.186]
        
        Proto-Oncogene Proteins c-mos [D12.776.624.664.700.187]
        
        Proto-Oncogene Proteins c-myb [D12.776.624.664.700.188]
        
        Proto-Oncogene Proteins c-myc [D12.776.624.664.700.189]
        
        Proto-Oncogene Proteins c-pim-1 [D12.776.624.664.700.191]
        
        Proto-Oncogene Proteins c-rel [D12.776.624.664.700.192]
        
        Proto-Oncogene Proteins c-ret [D12.776.624.664.700.194]
        
        Proto-Oncogene Proteins c-sis [D12.776.624.664.700.195]
        
        Proto-Oncogene Proteins c-vav [D12.776.624.664.700.198]
        
        Proto-Oncogene Proteins c-yes [D12.776.624.664.700.199]
        
        Proto-Oncogene Proteins p21(ras) [D12.776.624.664.700.200]
        
        Proto-Oncogene Proteins pp60(c-src) [D12.776.624.664.700.202]
        
        raf Kinases [D12.776.624.664.700.204]
        
        Receptor, ErbB-2 [D12.776.624.664.700.642]
        
        Receptor, ErbB-3 [D12.776.624.664.700.790]
        
        Receptor, ErbB-4 [D12.776.624.664.700.791]
        
        Receptor, Fibroblast Growth Factor, Type 3 [D12.776.624.664.700.792]
        
        Receptor, Macrophage Colony-Stimulating Factor [D12.776.624.664.700.800]
        
        Receptor, Notch4 [D12.776.624.664.700.815]
        
        Receptors, Thyroid Hormone [D12.776.624.664.700.830]
        
        RNA-Binding Protein EWS [D12.776.624.664.700.913]
        
        RNA-Binding Protein FUS [D12.776.624.664.700.915]
        
        RUNX1 Translocation Partner 1 Protein [D12.776.624.664.700.936]
        
        Stathmin [D12.776.624.664.700.957]
        
        T-Cell Acute Lymphocytic Leukemia Protein 1 [D12.776.624.664.700.960]
        
        Wnt-5a Protein [D12.776.624.664.700.962]
        
        Wnt1 Protein [D12.776.624.664.700.967]
        
        Wnt2 Protein [D12.776.624.664.700.978]
        
        Zinc Finger Protein GLI1 [D12.776.624.664.700.989]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Transcription Factors [D12.776.930]
    - Basic Helix-Loop-Helix Transcription Factors [D12.776.930.125]
      - Basic Helix-Loop-Helix Leucine Zipper Transcription Factors [D12.776.930.125.500]
        
        Microphthalmia-Associated Transcription Factor [D12.776.930.125.500.500]
        
        N-Myc Proto-Oncogene Protein [D12.776.930.125.500.563]
        
        Nuclear Receptor Coactivator 1 [D12.776.930.125.500.625]
        
        Sterol Regulatory Element Binding Proteins [D12.776.930.125.500.750]
        
        Transcription Factor 3 [D12.776.930.125.500.875]
        
        Transcription Factor 4 [D12.776.930.125.500.937]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Transcription Factors [D12.776.930]
    - Basic-Leucine Zipper Transcription Factors [D12.776.930.127]
      - Basic Helix-Loop-Helix Leucine Zipper Transcription Factors [D12.776.930.127.092]
        
        Microphthalmia-Associated Transcription Factor [D12.776.930.127.092.500]
        
        N-Myc Proto-Oncogene Protein [D12.776.930.127.092.625]
        
        Sterol Regulatory Element Binding Proteins [D12.776.930.127.092.750]
        
        Transcription Factor 3 [D12.776.930.127.092.875]

N-Myc Proto-Oncogene Protein Preferred

Concept UI: M000614703
Scope Note: A basic helix-loop-helix leucine zipper (bHLHZ) transcription factor and proto-oncogene protein that functions in cell growth and proliferation. In mammals, it is highly expressed in the brain during embryogenesis and is essential for brain development; it is not expressed in adult tissues. Amplification or overexpression of N-Myc occurs in at least 20% of tumors and is associated with a poor prognosis in cases of NEUROBLASTOMA; ALVEOLAR RHABDOMYOSARCOMA; SMALL CELL LUNG CARCINOMA; and neuroendocrine prostate cancer.
Terms: N-Myc Proto-Oncogene Protein Preferred Term
Term UI T000895431
Date02/17/2016
LexicalTag NON
ThesaurusID NLM (2017); N-Myc Protein
Term UI T000895432
Date02/17/2016
LexicalTag ABX
ThesaurusID NLM (2017); MYCN Protein
Term UI T000895433
Date02/17/2016
LexicalTag ABX
ThesaurusID NLM (2017); NMYC Protein
Term UI T000895434
Date02/17/2016
LexicalTag ABX
ThesaurusID NLM (2017); Class E Basic Helix-Loop-Helix Protein 37
Term UI T000895435
Date02/17/2016
LexicalTag NON
ThesaurusID NLM (2017); BHLHE37 Protein
Term UI T000895437
Date02/17/2016
LexicalTag ABX
ThesaurusID NLM (2017)

N-Myc Proto-Oncogene Protein MeSH Descriptor Data 2025