Sterol Regulatory Element Binding Proteins MeSH Descriptor Data 2026

MeSH Heading: Sterol Regulatory Element Binding Proteins
Tree Number(s): D12.776.260.103.500.750; D12.776.260.108.092.750; D12.776.930.125.500.750; D12.776.930.127.092.750
Unique ID: D051779
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D051779
Scope Note: Sterol regulatory element binding proteins are basic helix-loop-helix leucine zipper transcription factors that bind the sterol regulatory element TCACNCCAC. They are synthesized as precursors that are threaded into the MEMBRANES of the ENDOPLASMIC RETICULUM.
Entry Term(s): SREBP Protein; SREBP Proteins; Sterol Regulatory Element Binding Protein
Registry Numbers: 0
Public MeSH Note: 2006
History Note: 2006
Date Introduced: 2006/01/01
Last Updated: 2020/05/27

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - DNA-Binding Proteins [D12.776.260]
    - Basic Helix-Loop-Helix Proteins [D12.776.260.103]
      - Basic Helix-Loop-Helix Leucine Zipper Transcription Factors [D12.776.260.103.500]
        
        Microphthalmia-Associated Transcription Factor [D12.776.260.103.500.500]
        
        N-Myc Proto-Oncogene Protein [D12.776.260.103.500.625]
        
        Sterol Regulatory Element Binding Proteins [D12.776.260.103.500.750]
        
        Sterol Regulatory Element Binding Protein 1 [D12.776.260.103.500.750.500]
        
        Sterol Regulatory Element Binding Protein 2 [D12.776.260.103.500.750.750]
        
        Transcription Factor 3 [D12.776.260.103.500.875]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - DNA-Binding Proteins [D12.776.260]
    - Basic-Leucine Zipper Transcription Factors [D12.776.260.108]
      - Basic Helix-Loop-Helix Leucine Zipper Transcription Factors [D12.776.260.108.092]
        
        Microphthalmia-Associated Transcription Factor [D12.776.260.108.092.500]
        
        N-Myc Proto-Oncogene Protein [D12.776.260.108.092.625]
        
        Sterol Regulatory Element Binding Proteins [D12.776.260.108.092.750]
        
        Sterol Regulatory Element Binding Protein 1 [D12.776.260.108.092.750.500]
        
        Sterol Regulatory Element Binding Protein 2 [D12.776.260.108.092.750.750]
        
        Transcription Factor 3 [D12.776.260.108.092.875]
        
        Transcription Factor 4 [D12.776.260.108.092.937]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Transcription Factors [D12.776.930]
    - Basic Helix-Loop-Helix Proteins [D12.776.930.125]
      - Basic Helix-Loop-Helix Leucine Zipper Transcription Factors [D12.776.930.125.500]
        
        Microphthalmia-Associated Transcription Factor [D12.776.930.125.500.500]
        
        N-Myc Proto-Oncogene Protein [D12.776.930.125.500.563]
        
        Nuclear Receptor Coactivator 1 [D12.776.930.125.500.625]
        
        Sterol Regulatory Element Binding Proteins [D12.776.930.125.500.750]
        
        Sterol Regulatory Element Binding Protein 1 [D12.776.930.125.500.750.500]
        
        Sterol Regulatory Element Binding Protein 2 [D12.776.930.125.500.750.750]
        
        Transcription Factor 3 [D12.776.930.125.500.875]
        
        Transcription Factor 4 [D12.776.930.125.500.937]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Transcription Factors [D12.776.930]
    - Basic-Leucine Zipper Transcription Factors [D12.776.930.127]
      - Basic Helix-Loop-Helix Leucine Zipper Transcription Factors [D12.776.930.127.092]
        
        Microphthalmia-Associated Transcription Factor [D12.776.930.127.092.500]
        
        N-Myc Proto-Oncogene Protein [D12.776.930.127.092.625]
        
        Sterol Regulatory Element Binding Proteins [D12.776.930.127.092.750]
        
        Sterol Regulatory Element Binding Protein 1 [D12.776.930.127.092.750.500]
        
        Sterol Regulatory Element Binding Protein 2 [D12.776.930.127.092.750.750]
        
        Transcription Factor 3 [D12.776.930.127.092.875]

Sterol Regulatory Element Binding Proteins Preferred

Concept UI: M0481799
Registry Numbers: 0
Scope Note: Sterol regulatory element binding proteins are basic helix-loop-helix leucine zipper transcription factors that bind the sterol regulatory element TCACNCCAC. They are synthesized as precursors that are threaded into the MEMBRANES of the ENDOPLASMIC RETICULUM.
Terms: Sterol Regulatory Element Binding Proteins Preferred Term
Term UI T632927
Date03/10/2005
LexicalTag NON
ThesaurusID NLM (2006); Sterol Regulatory Element Binding Protein
Term UI T000999152
Date11/22/2019
LexicalTag NON
ThesaurusID NLM (2021); SREBP Proteins
Term UI T632928
Date03/10/2005
LexicalTag ABX
ThesaurusID NLM (2006); SREBP Protein
Term UI T000999153
Date11/22/2019
LexicalTag NON
ThesaurusID NLM (2021)

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