MeSH Browser

MeSH Heading: Proto-Oncogene Protein Spi-1
Tree Number(s): D12.776.260.755.375; D12.776.624.664.700.203; D12.776.930.900.475; D12.776.964.925.984.435
Unique ID: D000099232
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D000099232
Scope Note: An ETS MOTIF - containing trans-activator that functions in HEMATOPOIESIS. It activates transcription of critical genes by making genomic regions within HETEROCHROMATIN accessible to other key transcription factors.
Entry Term(s): NF-JB Protein; NFIL-1betaA Protein; NFbetaA Protein; PU.1 Protein; Pu-1 Protein; Transcription Factor PU.1; c-Spi-1 Protein
Registry Numbers: 0
Public MeSH Note: 2026; PROTO-ONCOGENE PROTEIN SPI-1 was indexed under PROTO-ONCOGENE PROTEINS and TRANS-ACTIVATORS 1990-2025
History Note: 2026 (1990); use PROTO-ONCOGENE PROTEIN SPI-1 (NM) 1990-2025
Date Introduced: 2026/01/01
Last Updated: 2026/01/01

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - DNA-Binding Proteins [D12.776.260]
    - Trans-Activators [D12.776.260.755]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Neoplasm Proteins [D12.776.624]
    - Oncogene Proteins [D12.776.624.664]
      - Proto-Oncogene Proteins [D12.776.624.664.700]
        
        Axl Receptor Tyrosine Kinase [D12.776.624.664.700.013]
        
        Bcl-2-Like Protein 11 [D12.776.624.664.700.025]
        
        c-Mer Tyrosine Kinase [D12.776.624.664.700.037]
        
        Chemokine CXCL1 [D12.776.624.664.700.049]
        
        Cyclin D1 [D12.776.624.664.700.100]
        
        Fibroblast Growth Factor 4 [D12.776.624.664.700.110]
        
        Fibroblast Growth Factor 6 [D12.776.624.664.700.112]
        
        fms-Like Tyrosine Kinase 3 [D12.776.624.664.700.114]
        
        Janus Kinase 2 [D12.776.624.664.700.117]
        
        KRIT1 Protein [D12.776.624.664.700.119]
        
        Kruppel-Like Factor 6 [D12.776.624.664.700.120]
        
        Lipocalin-2 [D12.776.624.664.700.123]
        
        Lymphocyte Specific Protein Tyrosine Kinase p56(lck) [D12.776.624.664.700.128]
        
        MDS1 and EVI1 Complex Locus Protein [D12.776.624.664.700.129]
        
        MutS Homolog 2 Protein [D12.776.624.664.700.130]
        
        Myeloid-Lymphoid Leukemia Protein [D12.776.624.664.700.148]
        
        N-Myc Proto-Oncogene Protein [D12.776.624.664.700.158]
        
        Pre-B-Cell Leukemia Transcription Factor 1 [D12.776.624.664.700.163]
        
        B-Cell Lymphoma 3 Protein [D12.776.624.664.700.165]
        
        Proto-Oncogene Mas [D12.776.624.664.700.166]
        
        Proto-Oncogene Proteins c-abl [D12.776.624.664.700.167]
        
        Proto-Oncogene Proteins c-akt [D12.776.624.664.700.168]
        
        Proto-Oncogene Proteins c-bcl-2 [D12.776.624.664.700.169]
        
        Proto-Oncogene Proteins c-bcl-6 [D12.776.624.664.700.170]
        
        Proto-Oncogene Proteins c-bcr [D12.776.624.664.700.171]
        
        Proto-Oncogene Proteins c-cbl [D12.776.624.664.700.172]
        
        Proto-Oncogene Proteins c-crk [D12.776.624.664.700.174]
        
        Proto-Oncogene Proteins c-ets [D12.776.624.664.700.175]
        
        Proto-Oncogene Proteins c-fes [D12.776.624.664.700.177]
        
        Proto-Oncogene Proteins c-fos [D12.776.624.664.700.179]
        
        Proto-Oncogene Proteins c-fyn [D12.776.624.664.700.180]
        
        Proto-Oncogene Proteins c-hck [D12.776.624.664.700.181]
        
        Proto-Oncogene Proteins c-jun [D12.776.624.664.700.182]
        
        Proto-Oncogene Proteins c-kit [D12.776.624.664.700.183]
        
        Proto-Oncogene Proteins c-maf [D12.776.624.664.700.184]
        
        Proto-Oncogene Proteins c-mdm2 [D12.776.624.664.700.185]
        
        Proto-Oncogene Proteins c-met [D12.776.624.664.700.186]
        
        Proto-Oncogene Proteins c-mos [D12.776.624.664.700.187]
        
        Proto-Oncogene Proteins c-myb [D12.776.624.664.700.188]
        
        Proto-Oncogene Proteins c-myc [D12.776.624.664.700.189]
        
        Proto-Oncogene Proteins c-pim-1 [D12.776.624.664.700.191]
        
        Proto-Oncogene Proteins c-rel [D12.776.624.664.700.192]
        
        Proto-Oncogene Proteins c-ret [D12.776.624.664.700.194]
        
        Proto-Oncogene Proteins c-sis [D12.776.624.664.700.195]
        
        Proto-Oncogene Proteins c-vav [D12.776.624.664.700.198]
        
        Proto-Oncogene Proteins c-yes [D12.776.624.664.700.199]
        
        Proto-Oncogene Proteins p21(ras) [D12.776.624.664.700.200]
        
        Proto-Oncogene Proteins pp60(c-src) [D12.776.624.664.700.202]
        
        Proto-Oncogene Protein Spi-1 [D12.776.624.664.700.203]
        
        raf Kinases [D12.776.624.664.700.204]
        
        Erb-b2 Receptor Tyrosine Kinases [D12.776.624.664.700.642]
        
        Receptor, ErbB-3 [D12.776.624.664.700.790]
        
        Receptor, ErbB-4 [D12.776.624.664.700.791]
        
        Receptor, Fibroblast Growth Factor, Type 3 [D12.776.624.664.700.792]
        
        Receptor, Macrophage Colony-Stimulating Factor [D12.776.624.664.700.800]
        
        Receptor, Notch4 [D12.776.624.664.700.815]
        
        Receptors, Thyroid Hormone [D12.776.624.664.700.830]
        
        RNA-Binding Protein EWS [D12.776.624.664.700.913]
        
        RNA-Binding Protein FUS [D12.776.624.664.700.915]
        
        RUNX1 Translocation Partner 1 Protein [D12.776.624.664.700.936]
        
        Stathmin [D12.776.624.664.700.957]
        
        T-Cell Acute Lymphocytic Leukemia Protein 1 [D12.776.624.664.700.960]
        
        Wnt-5a Protein [D12.776.624.664.700.962]
        
        Wnt1 Protein [D12.776.624.664.700.967]
        
        Wnt2 Protein [D12.776.624.664.700.978]
        
        Zinc Finger Protein GLI1 [D12.776.624.664.700.989]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Transcription Factors [D12.776.930]
    - Trans-Activators [D12.776.930.900]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Viral Proteins [D12.776.964]
    - Viral Regulatory and Accessory Proteins [D12.776.964.925]
      - Trans-Activators [D12.776.964.925.984]
        
        Gene Products, rev [D12.776.964.925.984.385]
        
        Gene Products, tat [D12.776.964.925.984.400]
        
        Gene Products, tax [D12.776.964.925.984.410]
        
        Gene Products, vpr [D12.776.964.925.984.430]
        
        Proto-Oncogene Protein Spi-1 [D12.776.964.925.984.435]
        
        Herpes Simplex Virus Protein Vmw65 [D12.776.964.925.984.445]

Proto-Oncogene Protein Spi-1 Preferred

Concept UI: M000769000
Registry Numbers: 0
Scope Note: An ETS MOTIF - containing trans-activator that functions in HEMATOPOIESIS. It activates transcription of critical genes by making genomic regions within HETEROCHROMATIN accessible to other key transcription factors.
Terms: Proto-Oncogene Protein Spi-1 Preferred Term
Term UI T001148920
Date06/10/2025
LexicalTag NON
ThesaurusID NLM (2026); NF-JB Protein
Term UI T001148371
Date05/05/2025
LexicalTag NON
ThesaurusID NLM (2026); NFbetaA Protein
Term UI T001148372
Date05/05/2025
LexicalTag NON
ThesaurusID NLM (2026); NFIL-1betaA Protein
Term UI T001148373
Date05/05/2025
LexicalTag NON
ThesaurusID NLM (2026); c-Spi-1 Protein
Term UI T001148370
Date05/05/2025
LexicalTag NON
ThesaurusID NLM (2026); PU.1 Protein
Term UI T001148375
Date05/05/2025
LexicalTag NON
ThesaurusID NLM (2026); Transcription Factor PU.1
Term UI T001148376
Date05/05/2025
LexicalTag NON
ThesaurusID NLM (2026); Pu-1 Protein
Term UI T001148374
Date05/05/2025
LexicalTag NON
ThesaurusID NLM (2026)

Proto-Oncogene Protein Spi-1 MeSH Descriptor Data 2026