MeSH Browser

MeSH Heading: Proto-Oncogene Proteins c-raf
Tree Number(s): D08.811.913.696.620.682.700.559.842.500; D12.776.476.563.554.842.500; D12.776.624.664.700.204.500
Unique ID: D019908
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D019908
Scope Note: A ubiquitously expressed raf kinase subclass that plays an important role in SIGNAL TRANSDUCTION. The c-raf Kinases are MAP kinase kinase kinases that have specificity for MAP KINASE KINASE 1 and MAP KINASE KINASE 2.
Entry Term(s): Kinase Raf-1; Kinase p74(raf-1); Proto-Oncogene Protein c-raf; c-raf Kinases; c-raf Proteins; cRaf1 Kinase; raf-1 Kinase
Registry Numbers: EC 2.7.11.1
Previous Indexing: Protein-Serine-Threonine Kinases (1993-1997); Proto-Oncogene Proteins (1986-1997)
See Also: Oncogene Proteins v-raf
Public MeSH Note: 1998; PROTO-ONCOGENE PROTEIN MIL (now PROTO-ONCOGENE PROTEINS C-RAF) was indexed under PROTEIN-SERINE-THEONINE KINASES 1993-1997 & PROTO-ONCOGENE PROTEINS 1986-1997; CRAF1 KINASE was indexed under PROTO-ONCOGENE PROTEINS C-RAF 1993-2004
History Note: 1998 (1986)
Date Established: 1998/01/01
Date of Entry: 1997/06/20
Revision Date: 2021/05/21

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M0029578
Registry Numbers: EC 2.7.11.1
Scope Note: A ubiquitously expressed raf kinase subclass that plays an important role in SIGNAL TRANSDUCTION. The c-raf Kinases are MAP kinase kinase kinases that have specificity for MAP KINASE KINASE 1 and MAP KINASE KINASE 2.
Terms: Proto-Oncogene Proteins c-raf Preferred Term
Term UI T059319
Date01/01/1999
LexicalTag NON
ThesaurusID NLM (1998); Proto-Oncogene Protein c-raf
Term UI T059318
Date02/24/1997
LexicalTag NON
ThesaurusID NLM (1998); Kinase p74(raf-1)
Term UI T437709
Date03/02/2001
LexicalTag NON
ThesaurusID NLM (2005); Kinase Raf-1
Term UI T437710
Date03/02/2001
LexicalTag NON
ThesaurusID NLM (2005); cRaf1 Kinase
Term UI T476720
Date01/09/2002
LexicalTag NON
ThesaurusID NLM (2005); raf-1 Kinase
Term UI T574616
Date02/27/2004
LexicalTag NON
ThesaurusID NLM (2005); c-raf Proteins
Term UI T059317
Date02/24/1997
LexicalTag NON
ThesaurusID NLM (1998); c-raf Kinases
Term UI T574623
Date02/27/2004
LexicalTag NON
ThesaurusID NLM (2005)

Proto-Oncogene Proteins c-raf MeSH Descriptor Data 2025