MeSH Browser

MeSH Heading: Calmodulin
Tree Number(s): D12.644.360.372.249; D12.776.157.125.412.249; D12.776.476.387.249
Unique ID: D002147
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D002147
Annotation: a calcium-binding protein; /‌biosyn /‌physiol permitted
Scope Note: A heat-stable, low-molecular-weight activator protein found mainly in the brain and heart. The binding of calcium ions to this protein allows this protein to bind to cyclic nucleotide phosphodiesterases and to adenyl cyclase with subsequent activation. Thereby this protein modulates cyclic AMP and cyclic GMP levels.
Entry Term(s): Bovine Activator Protein; Calcium-Dependent Activator Protein; Calcium-Dependent Regulator; Cyclic AMP-Phosphodiesterase Activator; Phosphodiesterase Activating Factor; Phosphodiesterase Activator Protein; Phosphodiesterase Protein Activator; Regulator, Calcium-Dependent
Registry Numbers: 0
NLM Classification #: QU 55.2
Previous Indexing: Calcium (1966-1978); Carrier Proteins (1971-1978); Enzyme Activation (1969-1978)
Public MeSH Note: 84; was CALCIUM-DEPENDENT REGULATOR see under CALCIUM-BINDING PROTEINS 1980-83; was CALCIUM-DEPENDENT REGULATOR see under CARRIER PROTEINS 1979
Online Note: use CALMODULIN to search CALCIUM-DEPENDENT REGULATOR 1979-83
History Note: 84; was CALCIUM-DEPENDENT REGULATOR see under CALCIUM-BINDING PROTEINS 1980-83; was CALCIUM-DEPENDENT REGULATOR see under CARRIER PROTEINS 1979
Date Established: 1984/01/01
Date of Entry: 1978/03/08
Revision Date: 2017/06/30

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Amino Acids, Peptides, and Proteins [D12]
- Peptides [D12.644]
  - Intracellular Signaling Peptides and Proteins [D12.644.360]
    - Intracellular Calcium-Sensing Proteins [D12.644.360.372]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Carrier Proteins [D12.776.157]
    - Calcium-Binding Proteins [D12.776.157.125]
      - Intracellular Calcium-Sensing Proteins [D12.776.157.125.412]
        
        Calmodulin [D12.776.157.125.412.249]
        
        Calnexin [D12.776.157.125.412.311]
        
        Calreticulin [D12.776.157.125.412.374]
        
        Gelsolin [D12.776.157.125.412.437]
        
        Neuronal Calcium-Sensor Proteins [D12.776.157.125.412.500]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Intracellular Signaling Peptides and Proteins [D12.776.476]
    - Intracellular Calcium-Sensing Proteins [D12.776.476.387]

Calmodulin Preferred

Concept UI: M0003213
Registry Numbers: 0
Scope Note: A heat-stable, low-molecular-weight activator protein found mainly in the brain and heart. The binding of calcium ions to this protein allows this protein to bind to cyclic nucleotide phosphodiesterases and to adenyl cyclase with subsequent activation. Thereby this protein modulates cyclic AMP and cyclic GMP levels.
Terms: Calmodulin Preferred Term
Term UI T006139
Date01/01/1999
LexicalTag NON
ThesaurusID NLM (1979); Calcium-Dependent Regulator
Term UI T006137
Date04/04/1983
LexicalTag NON
ThesaurusID UNK (19XX); Calcium-Dependent Activator Protein
Term UI T006138
Date03/08/1978
LexicalTag NON
ThesaurusID UNK (19XX); Regulator, Calcium-Dependent
Term UI T006136
Date10/15/1990
LexicalTag NON
ThesaurusID NLM (1992); Phosphodiesterase Activating Factor
Term UI T006140
Date11/04/1980
LexicalTag NON
ThesaurusID UNK (19XX); Phosphodiesterase Activator Protein
Term UI T006141
Date11/04/1980
LexicalTag NON
ThesaurusID UNK (19XX); Phosphodiesterase Protein Activator
Term UI T006142
Date11/04/1980
LexicalTag NON
ThesaurusID UNK (19XX)

Bovine Activator Protein Narrower

Cyclic AMP-Phosphodiesterase Activator Narrower

Calmodulin MeSH Descriptor Data 2025