MeSH Browser

MeSH Heading: Gelsolin
Tree Number(s): D05.750.078.730.350; D12.644.360.372.437; D12.776.157.125.412.437; D12.776.220.525.350; D12.776.476.387.437
Unique ID: D018260
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D018260
Scope Note: A 90-kDa protein produced by macrophages that severs ACTIN filaments and forms a cap on the newly exposed filament end. Gelsolin is activated by CALCIUM ions and participates in the assembly and disassembly of actin, thereby increasing the motility of some CELLS.
Entry Term(s): Gelsolin Protein; Serum Actin Inhibitory Protein
Public MeSH Note: 1994; GELSOLIN was indexed under CALCIUM-BINDING PROTEINS and MICROFILAMENT PROTEINS 1980-1993; SERUM ACTIN IHIBITORY PROTEIN was indexed under MICROFILAMENT PROTEINS 1988-2005, & under MUSCLE PROTEINS & PROTEINS 1986-1987
History Note: 1994(1980)
Date Established: 1994/01/01
Date of Entry: 1993/06/03
Revision Date: 2017/06/30

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Gelsolin MeSH Descriptor Data 2025