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Filamins MeSH Descriptor Data 2023


MeSH Heading
Filamins
Tree Number(s)
A11.284.430.214.190.750.050.414
D05.750.078.730.315
D12.776.210.249
D12.776.220.525.315
Unique ID
D064448
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D064448
Scope Note
A family of crosslinking filament proteins encoded by distinct FLN genes. Filamins are involved in cell adhesion, spreading, and migration, acting as scaffolds for over 90 binding partners including channels, receptors, intracellular signaling molecules and transcription factors. Due to the range of molecular interactions, mutations in FLN genes result in anomalies with moderate to lethal consequences.
Entry Term(s)
280 kDa Actin-Binding Protein
Filamin
Filamin 1
Filamin 1-Like Protein
Filamin A
Filamin B
Filamin C
Merofilamins
alpha-Filamin
beta-Filamin
Registry Number
0
Public MeSH Note
2014; was indexed under CONTRACTILE PROTEINS and MICROFILAMENT PROTEINS 1977-2013.
History Note
2014
Date Established
2014/01/01
Date of Entry
2013/07/08
Revision Date
2016/06/28
Filamins Preferred
Filamin B Narrower
Merofilamins Narrower
Filamin A Narrower
Filamin C Narrower
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