MeSH Browser

MeSH Heading: Filamins
Tree Number(s): A11.284.430.214.190.750.050.414; D05.750.078.730.315; D12.776.210.249; D12.776.220.525.315
Unique ID: D064448
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D064448
Scope Note: A family of crosslinking filament proteins encoded by distinct FLN genes. Filamins are involved in cell adhesion, spreading, and migration, acting as scaffolds for over 90 binding partners including channels, receptors, intracellular signaling molecules and transcription factors. Due to the range of molecular interactions, mutations in FLN genes result in anomalies with moderate to lethal consequences.
Entry Term(s): 280 kDa Actin-Binding Protein; Filamin; Filamin 1; Filamin 1-Like Protein; Filamin A; Filamin B; Filamin C; Merofilamins; alpha-Filamin; beta-Filamin
Public MeSH Note: 2014; was indexed under CONTRACTILE PROTEINS and MICROFILAMENT PROTEINS 1977-2013.
History Note: 2014
Date Established: 2014/01/01
Date of Entry: 2013/07/08
Revision Date: 2016/06/28

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M0491333
Terms: Filamin A Preferred Term
Term UI T838186
Date03/05/2013
LexicalTag NON
ThesaurusID NLM (2014); 280 kDa Actin-Binding Protein
Term UI T838187
Date03/05/2013
LexicalTag NON
ThesaurusID NLM (2014); Filamin 1
Term UI T838189
Date03/05/2013
LexicalTag NON
ThesaurusID NLM (2014); alpha-Filamin
Term UI T838256
Date03/07/2013
LexicalTag NON
ThesaurusID NLM (2014)

Filamins MeSH Descriptor Data 2025