MeSH Browser

MeSH Heading: Calreticulin
Tree Number(s): D12.644.360.372.374; D12.776.157.125.412.374; D12.776.476.387.374; D12.776.503.303
Unique ID: D037282
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D037282
Scope Note: A multifunctional protein that is found primarily within membrane-bound organelles. In the ENDOPLASMIC RETICULUM it binds to specific N-linked oligosaccharides found on newly-synthesized proteins and functions as a MOLECULAR CHAPERONE that may play a role in PROTEIN FOLDING or retention and degradation of misfolded proteins. In addition calreticulin is a major storage form for CALCIUM and functions as a calcium-signaling molecule that can regulate intracellular calcium HOMEOSTASIS.
Entry Term(s): 55-kDa High-Affinity Calcium Binding Protein; CAB-63; CBP3 (Liver); Calcium-Binding Protein-3; Calregulin; ERp60; HACBP; cC1qR Protein
Previous Indexing: Calcium-Binding Proteins (1990-2002)
Public MeSH Note: 2003; CALRETICULIN was indexed under CALCIUM-BINDING PROTEINS 1990-2002
History Note: 2003; use CALRETICULIN (NM) 1990-2002
Date Established: 2003/01/01
Date of Entry: 2002/07/03
Revision Date: 2017/06/30

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Amino Acids, Peptides, and Proteins [D12]
- Peptides [D12.644]
  - Intracellular Signaling Peptides and Proteins [D12.644.360]
    - Intracellular Calcium-Sensing Proteins [D12.644.360.372]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Carrier Proteins [D12.776.157]
    - Calcium-Binding Proteins [D12.776.157.125]
      - Intracellular Calcium-Sensing Proteins [D12.776.157.125.412]
        
        Calmodulin [D12.776.157.125.412.249]
        
        Calnexin [D12.776.157.125.412.311]
        
        Calreticulin [D12.776.157.125.412.374]
        
        Gelsolin [D12.776.157.125.412.437]
        
        Neuronal Calcium-Sensor Proteins [D12.776.157.125.412.500]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Intracellular Signaling Peptides and Proteins [D12.776.476]
    - Intracellular Calcium-Sensing Proteins [D12.776.476.387]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Lectins [D12.776.503]

Calreticulin Preferred

Concept UI: M0172278
Scope Note: A multifunctional protein that is found primarily within membrane-bound organelles. In the ENDOPLASMIC RETICULUM it binds to specific N-linked oligosaccharides found on newly-synthesized proteins and functions as a MOLECULAR CHAPERONE that may play a role in PROTEIN FOLDING or retention and degradation of misfolded proteins. In addition calreticulin is a major storage form for CALCIUM and functions as a calcium-signaling molecule that can regulate intracellular calcium HOMEOSTASIS.
Terms: Calreticulin Preferred Term
Term UI T202283
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2003); CAB-63
Term UI T202273
Date01/01/1955
LexicalTag ACR
ThesaurusID NLM (2003); CBP3 (Liver)
Term UI T202274
Date01/01/1955
LexicalTag ACX
ThesaurusID NLM (2003); ERp60
Term UI T202275
Date01/01/1955
LexicalTag ACR
ThesaurusID NLM (2003); 55-kDa High-Affinity Calcium Binding Protein
Term UI T479304
Date01/25/2002
LexicalTag NON
ThesaurusID NLM (2003); cC1qR Protein
Term UI T202277
Date01/01/1955
LexicalTag ACX
ThesaurusID NLM (2003); Calcium-Binding Protein-3
Term UI T202278
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2003); Calregulin
Term UI T202279
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2003); HACBP
Term UI T202276
Date01/01/1955
LexicalTag ACR
ThesaurusID NLM (2003)

Calreticulin MeSH Descriptor Data 2025