MeSH Browser

MeSH Heading: Sirtuin 1
Tree Number(s): D08.811.277.087.520.200.650.100; D12.776.476.900.100
Unique ID: D056564
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D056564
Scope Note: A sirtuin family member found primarily in the CELL NUCLEUS. It is an NAD-dependent deacetylase with specificity towards HISTONES and a variety of proteins involved in gene regulation.
Entry Term(s): Silent Mating Type Information Regulation 2 Homolog 1; Sirt1
Previous Indexing: Histone Deacetylases (2002-2006); Sirtuins (2007-2009)
Public MeSH Note: 2010
History Note: 2010
Date Established: 2010/01/01
Date of Entry: 2009/07/06
Revision Date: 2018/06/14

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Sirtuin 1 MeSH Descriptor Data 2025