MeSH Browser

MeSH Heading: Protein Phosphatase 1
Tree Number(s): D08.811.277.352.650.625.687; D12.776.476.559.687
Unique ID: D054645
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D054645
Scope Note: A eukayrotic protein serine-threonine phosphatase subtype that dephosphorylates a wide variety of cellular proteins. The enzyme is comprised of a catalytic subunit and regulatory subunit. Several isoforms of the protein phosphatase catalytic subunit exist due to the presence of multiple genes and the alternative splicing of their mRNAs. A large number of proteins have been shown to act as regulatory subunits for this enzyme. Many of the regulatory subunits have additional cellular functions.
Entry Term(s): PP1c Enzyme; Phosphoprotein Phosphatase-1 delta; Phosphoprotein Phosphatase-1 gamma 1; Protein Phosphatase 1, Catalytic Subunit; Protein Phosphatase 1, Catalytic Subunit, alpha Isoform; Protein Phosphatase 1, Catalytic Subunit, beta Isoform; Protein Phosphatase 1, Catalytic Subunit, delta Isoform; Protein Phosphatase 1, Catalytic Subunit, gamma Isoform; Protein Phosphatase 1, Catalytic Subunit, gamma1 Isoform; Protein Phosphatase 1, Catalytic Subunit, gamma2 Isoform; Protein Phosphatase 1, Inhibitory Subunit; Protein Phosphatase 1, Regulatory Subunit; Protein Phosphatase 1C; Protein Phosphatase 1C gamma; Protein Phosphatase 1gamma; Protein Phosphatase-1; Protein Phosphatase-1 alpha; Protein Phosphatase-1 gamma 2; Protein Phosphatase-1G; Protein Serine-Threonine Phosphatase 1 beta; Protein-Serine-Threonine Phosphatase 1 beta; Type 1 Serine Threonine Protein Phosphatase
Related Numbers: EC 3.1.3.16
Previous Indexing: Phosphoprotein Phosphatases (1984-2007)
Public MeSH Note: 2008; for PROTEIN PHOSPHATASE-1 see PHOSPHOPROTEIN PHOSPHATASE 1984-2007; PROTEIN PHOSPHATASE 1C GAMMA was indexed under PHOSPHOPROTEIN PHOSPHATASES 1997-2007 & under PROTEIN-SERINE-THREONINE KINASES 1997-2006; PROTEIN-SERINE-THREONINE PHOSPHATASE 1 BETA was indexed under PHOSPHOPROTEIN PHOSPHATASE 1994-2007; TYPE 1 SERINE THREONINE PROTEIN PHOSPHATASE was indexed under PHOSPHOPROTEIN PHOSPHATASES 2002-2007
History Note: 2008(1983); for PROTEIN PHOSPHATASE-1 use PHOSPHOPROTEIN PHOSPHATASES 1984-2007
Date Established: 2008/01/01
Date of Entry: 2007/07/09
Revision Date: 2021/05/21

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Enzymes and Coenzymes [D08]
- Enzymes [D08.811]
  - Hydrolases [D08.811.277]
    - Esterases [D08.811.277.352]
      - Phosphoric Monoester Hydrolases [D08.811.277.352.650]
        
        Phosphoprotein Phosphatases [D08.811.277.352.650.625]
        
        Calcineurin [D08.811.277.352.650.625.150]
        
        Dual-Specificity Phosphatases [D08.811.277.352.650.625.225]
        
        Glycogen-Synthase-D Phosphatase [D08.811.277.352.650.625.300]
        
        Myosin-Light-Chain Phosphatase [D08.811.277.352.650.625.475]
        
        Phosphorylase Phosphatase [D08.811.277.352.650.625.650]
        
        Protein Phosphatase 1 [D08.811.277.352.650.625.687]
        
        Protein Phosphatase 2 [D08.811.277.352.650.625.706]
        
        Protein Phosphatase 2C [D08.811.277.352.650.625.716]
        
        Pyruvate Dehydrogenase (Lipoamide)-Phosphatase [D08.811.277.352.650.625.725]
        
        Tartrate-Resistant Acid Phosphatase [D08.811.277.352.650.625.862]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Intracellular Signaling Peptides and Proteins [D12.776.476]
    - Phosphoprotein Phosphatases [D12.776.476.559]

Protein Phosphatase 1 Preferred

Concept UI: M0506638
Related Numbers: EC 3.1.3.16
Scope Note: A eukayrotic protein serine-threonine phosphatase subtype that dephosphorylates a wide variety of cellular proteins. The enzyme is comprised of a catalytic subunit and regulatory subunit. Several isoforms of the protein phosphatase catalytic subunit exist due to the presence of multiple genes and the alternative splicing of their mRNAs. A large number of proteins have been shown to act as regulatory subunits for this enzyme. Many of the regulatory subunits have additional cellular functions.
Terms: Protein Phosphatase 1 Preferred Term
Term UI T691549
Date02/12/2007
LexicalTag NON
ThesaurusID NLM (2008); Protein Phosphatase-1
Term UI T031762
Date09/15/1983
LexicalTag NON
ThesaurusID UNK (19XX); Type 1 Serine Threonine Protein Phosphatase
Term UI T482480
Date02/19/2002
LexicalTag NON
ThesaurusID NLM (2008); PP1c Enzyme
Term UI T482481
Date02/19/2002
LexicalTag ABX
ThesaurusID NLM (2008)

Protein Phosphatase 1, Catalytic Subunit, gamma1 Isoform Narrower

Protein Phosphatase 1, Catalytic Subunit, alpha Isoform Narrower

Protein Phosphatase 1, Catalytic Subunit, gamma2 Isoform Narrower

Protein Phosphatase 1, Catalytic Subunit, beta Isoform Narrower

Protein Phosphatase 1, Catalytic Subunit, gamma Isoform Narrower

Protein Phosphatase 1, Catalytic Subunit Narrower

Protein Phosphatase 1, Catalytic Subunit, delta Isoform Narrower

Protein Phosphatase 1, Regulatory Subunit Narrower

Protein Phosphatase 1 MeSH Descriptor Data 2025