MeSH Browser

MeSH Heading: Protein Phosphatase 2
Tree Number(s): D08.811.277.352.650.625.706; D12.776.476.559.706
Unique ID: D054648
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D054648
Scope Note: A phosphoprotein phosphatase subtype that is comprised of a catalytic subunit and two different regulatory subunits. At least two genes encode isoforms of the protein phosphatase catalytic subunit, while several isoforms of regulatory subunits exist due to the presence of multiple genes and the alternative splicing of their mRNAs. Protein phosphatase 2 acts on a broad variety of cellular proteins and may play a role as a regulator of intracellular signaling processes.
Entry Term(s): PPP2CA Phosphatase; PPP2CB Phosphatase; Protein Phosphatase 2, Catalytic Subunit; Protein Phosphatase 2, Catalytic Subunit, alpha Isoform; Protein Phosphatase 2, Catalytic Subunit, beta Isoform; Protein Phosphatase 2, Regulatory Subunit; Protein Phosphatase 2, Regulatory Subunit A, alpha Isoform; Protein Phosphatase 2, Regulatory Subunit A, beta Isoform; Protein Phosphatase 2, Regulatory Subunit B, alpha Isoform; Protein Phosphatase 2, Regulatory Subunit B, beta Isoform; Protein Phosphatase 2, Regulatory Subunit B, delta Isoform; Protein Phosphatase 2, Regulatory Subunit B, gamma Isoform; Protein Phosphatase 2A, Catalytic Subunit, alpha Isoform; Protein Phosphatase 2A, Catalytic Subunit, beta Isoform; Protein Phosphatase 2A, Regulatory Subunit A, alpha Isoform; Protein Phosphatase 2A, Regulatory Subunit A, beta Isoform; Protein Phosphatase 2A, Regulatory Subunit B, alpha Isoform; Protein Phosphatase 2A, Regulatory Subunit B, beta Isoform; Protein Phosphatase 2A, Regulatory Subunit B, delta Isoform; Protein Phosphatase 2A, Regulatory Subunit B, gamma Isoform; Protein Phosphatase-2A; Serine Threonine Protein Phosphatase 2A Catalytic Subunit beta Isoform; Serine-Threonine-Protein Phosphatase 2A Catalytic Subunit alpha Isoform
Related Numbers: EC 3.1.3.16
Previous Indexing: Phosphoprotein Phosphatases (1985-2007)
Public MeSH Note: 2008; for PROTEIN PHOSPHATASE-2A see PHOSPHOPROTEIN PHOSPHATASE 1 1985-2007
History Note: 2008(1985); for PROTEIN PHOSPHATASE-2A use PHOSPHOPROTEIN PHOSPHATASE 1 1985-2007
Date Established: 2008/01/01
Date of Entry: 2024/08/09
Revision Date: 2024/02/13

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Enzymes and Coenzymes [D08]
- Enzymes [D08.811]
  - Hydrolases [D08.811.277]
    - Esterases [D08.811.277.352]
      - Phosphoric Monoester Hydrolases [D08.811.277.352.650]
        
        Phosphoprotein Phosphatases [D08.811.277.352.650.625]
        
        Calcineurin [D08.811.277.352.650.625.150]
        
        Dual-Specificity Phosphatases [D08.811.277.352.650.625.225]
        
        Glycogen-Synthase-D Phosphatase [D08.811.277.352.650.625.300]
        
        Myosin-Light-Chain Phosphatase [D08.811.277.352.650.625.475]
        
        Phosphorylase Phosphatase [D08.811.277.352.650.625.650]
        
        Protein Phosphatase 1 [D08.811.277.352.650.625.687]
        
        Protein Phosphatase 2 [D08.811.277.352.650.625.706]
        
        Protein Phosphatase 2C [D08.811.277.352.650.625.716]
        
        Pyruvate Dehydrogenase (Lipoamide)-Phosphatase [D08.811.277.352.650.625.725]
        
        Tartrate-Resistant Acid Phosphatase [D08.811.277.352.650.625.862]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Intracellular Signaling Peptides and Proteins [D12.776.476]
    - Phosphoprotein Phosphatases [D12.776.476.559]

Protein Phosphatase 2 Preferred

Protein Phosphatase 2, Catalytic Subunit, alpha Isoform Narrower

Protein Phosphatase 2, Catalytic Subunit, beta Isoform Narrower

Protein Phosphatase 2, Regulatory Subunit A, alpha Isoform Narrower

Protein Phosphatase 2, Regulatory Subunit A, beta Isoform Narrower

Protein Phosphatase 2, Regulatory Subunit B, beta Isoform Narrower

Protein Phosphatase 2, Regulatory Subunit B, alpha Isoform Narrower

Protein Phosphatase 2, Regulatory Subunit B, gamma Isoform Narrower

Protein Phosphatase 2, Regulatory Subunit B, delta Isoform Narrower

Protein Phosphatase 2, Catalytic Subunit Narrower

Protein Phosphatase 2, Regulatory Subunit Narrower

Protein Phosphatase 2 MeSH Descriptor Data 2025