MeSH Browser

MeSH Heading: Lymphocyte Activation
Tree Number(s): E01.370.225.812.482; E05.200.812.482; E05.478.594.530; G12.450.050.400.545; G12.565
Unique ID: D008213
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D008213
Annotation: lymphocyte transformation test goes here but do not index under specific agent inducing transformation unless particularly discussed; do not use for neoplastic transformation of lymphocytes ( = CELL TRANSFORMATION, NEOPLASTIC) or viral transformation of lymphocytes ( = CELL TRANSFORMATION, VIRAL); blast transformation in chronic myelogenous leukemia does not go here: index BLAST CRISIS
Scope Note: Morphologic alteration of small B LYMPHOCYTES or T LYMPHOCYTES in culture into large blast-like cells able to synthesize DNA and RNA and to divide mitotically. It is induced by INTERLEUKINS; MITOGENS such as PHYTOHEMAGGLUTININS, and by specific ANTIGENS. It may also occur in vivo as in GRAFT REJECTION.
Entry Term(s): Blast Transformation; Blastogenesis; Lymphoblast Transformation; Lymphocyte Stimulation; Lymphocyte Transformation; Transformation, Blast; Transformation, Lymphoblast; Transformation, Lymphocyte
NLM Classification #: QW 525.5.L9
Previous Indexing: Lymphocytes/immunology (1966-1968)
See Also: Blast Crisis
Public MeSH Note: 2003; see LYMPHOCYTE TRANSFORMATION 1972-2002; for BLAST TRANSFORMATION see BLAST CRISIS 1987-1992
History Note: 2003 (1969); for BLAST TRANSFORMATION use BLAST CRISIS 1987-1992
Date Established: 1972/01/01
Date of Entry: 1999/01/01
Revision Date: 2019/05/24

Allowable Qualifiers: drug effects (DE)

genetics (GE)

immunology (IM)

physiology (PH)

radiation effects (RE)

Diagnosis [E01]
- Diagnostic Techniques and Procedures [E01.370]
  - Clinical Laboratory Techniques [E01.370.225]
    - Immunologic Tests [E01.370.225.812]

Investigative Techniques [E05]
- Clinical Laboratory Techniques [E05.200]
  - Immunologic Tests [E05.200.812]

Investigative Techniques [E05]
- Immunologic Techniques [E05.478]
  - Immunologic Tests [E05.478.594]

Immune System Phenomena [G12]
- Immunity [G12.450]
  - Adaptive Immunity [G12.450.050]
    - Immunity, Cellular [G12.450.050.400]

Immune System Phenomena [G12]

Lymphocyte Activation Preferred

Concept UI: M0012805
Scope Note: Morphologic alteration of small B LYMPHOCYTES or T LYMPHOCYTES in culture into large blast-like cells able to synthesize DNA and RNA and to divide mitotically. It is induced by INTERLEUKINS; MITOGENS such as PHYTOHEMAGGLUTININS, and by specific ANTIGENS. It may also occur in vivo as in GRAFT REJECTION.
Terms: Lymphocyte Activation Preferred Term
Term UI T024465
Date04/16/1979
LexicalTag NON
ThesaurusID UNK (19XX); Blast Transformation
Term UI T024463
Date09/24/1991
LexicalTag NON
ThesaurusID NLM (1993); Blastogenesis
Term UI T024464
Date05/05/1989
LexicalTag NON
ThesaurusID NLM (1990); Transformation, Lymphocyte
Term UI T024466
Date09/13/1993
LexicalTag NON
ThesaurusID NLM (1995); Lymphocyte Transformation
Term UI T024467
Date01/01/1999
LexicalTag NON
ThesaurusID NLM (1969); Transformation, Lymphoblast
Term UI T024468
Date09/13/1993
LexicalTag NON
ThesaurusID NLM (1995); Lymphoblast Transformation
Term UI T024469
Date10/16/1991
LexicalTag NON
ThesaurusID NLM (1993); Transformation, Blast
Term UI T024462
Date09/13/1993
LexicalTag NON
ThesaurusID NLM (1995); Lymphocyte Stimulation
Term UI T024470
Date05/05/1989
LexicalTag NON
ThesaurusID NLM (1990)

Lymphocyte Activation MeSH Descriptor Data 2025