MeSH Browser

MeSH Heading: NADPH Oxidase 2
Tree Number(s): D08.811.682.608.575.875; D12.776.331.894.875; D12.776.543.653.875
Unique ID: D000074662
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D000074662
Scope Note: An NADPH oxidase that is expressed by PHAGOCYTES where it transfers electrons across the plasma membrane from cytosolic NADPH to molecular oxygen on the exterior. It regulates proton (H+) flux into resting phagocytes to control intracellular pH. Mutations in the CYBB gene are associated with X-LINKED CHRONIC GRANULOMATOUS DISEASE.
Entry Term(s): CYBB Protein; Chronic Granulomatous Disease Protein; Cytochrome B-245 Beta Chain; GP91-PHOX Protein; NOX2 Protein
Previous Indexing: Membrane Glycoproteins (1988-2017); NADPH Oxidases (1997-2017)
Public MeSH Note: 2018
History Note: 2018
Date Established: 2018/01/01
Date of Entry: 2017/07/11
Revision Date: 2017/04/05

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M000627303
Scope Note: An NADPH oxidase that is expressed by PHAGOCYTES where it transfers electrons across the plasma membrane from cytosolic NADPH to molecular oxygen on the exterior. It regulates proton (H+) flux into resting phagocytes to control intracellular pH. Mutations in the CYBB gene are associated with X-LINKED CHRONIC GRANULOMATOUS DISEASE.
Terms: NADPH Oxidase 2 Preferred Term
Term UI T000916828
Date03/06/2017
LexicalTag NON
ThesaurusID NLM (2018); Cytochrome B-245 Beta Chain
Term UI T000916830
Date03/06/2017
LexicalTag NON
ThesaurusID NLM (2018); NOX2 Protein
Term UI T000916831
Date03/06/2017
LexicalTag ABX
ThesaurusID NLM (2018); GP91-PHOX Protein
Term UI T000916832
Date03/06/2017
LexicalTag ABX
ThesaurusID NLM (2018); CYBB Protein
Term UI T000916829
Date03/06/2017
LexicalTag ABX
ThesaurusID NLM (2018); Chronic Granulomatous Disease Protein
Term UI T000916833
Date03/06/2017
LexicalTag NON
ThesaurusID NLM (2018)

NADPH Oxidase 2 MeSH Descriptor Data 2025