- Concept UI
- M0453577
- Registry Numbers
- EC 2.3.2.26
- Scope Note
- E3 ubiquitin ligases that consist of four WW DOMAINS. They accept UBIQUITIN from E2 UBIQUITIN-CONJUGATING ENZYME as a thioester via their C-terminal HECT domains and transfer it specifically to the 63rd LYSINE residue (Lys-63) of target proteins. NEDD4 targets include many proteins and receptors with important functions for cell growth and homeostasis such as VEGFR-2; FGFR1 TYROSINE KINASE; and ERBB-4 RECEPTOR. They play a critical role in the internalization of these receptors, their degradation by LYSOSOMES, and also function as part of the ESCRT complex in VIRUS RELEASE.
- Terms
-
Nedd4 Ubiquitin Protein Ligases
Preferred Term
Term UI
T000923775
Date05/09/2017
LexicalTag
ACX
ThesaurusID
NLM (2003)
-
Nedd4 Proteins
Term UI
T000923777
Date05/09/2017
LexicalTag
ACX
ThesaurusID
NLM (2018)
-
Neuronal Precursor Cell-Expressed Developmentally Down-Regulated 4 Ligase
Term UI
T000923776
Date05/09/2017
LexicalTag
NON
ThesaurusID
NLM (2003)