MeSH Browser

MeSH Heading: Nedd4 Ubiquitin Protein Ligases
Tree Number(s): D05.500.199.500; D08.811.464.938.750.257; D12.776.543.990.493.500
Unique ID: D000075702
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D000075702
Scope Note: E3 ubiquitin ligases that consist of four WW DOMAINS. They accept UBIQUITIN from E2 UBIQUITIN-CONJUGATING ENZYME as a thioester via their C-terminal HECT domains and transfer it specifically to the 63rd LYSINE residue (Lys-63) of target proteins. NEDD4 targets include many proteins and receptors with important functions for cell growth and homeostasis such as VEGFR-2; FGFR1 TYROSINE KINASE; and ERBB-4 RECEPTOR. They play a critical role in the internalization of these receptors, their degradation by LYSOSOMES, and also function as part of the ESCRT complex in VIRUS RELEASE.
Entry Term(s): Nedd4 Proteins; Neuronal Precursor Cell-Expressed Developmentally Down-Regulated 4 Ligase
Public MeSH Note: 2018; NEDD4 UBIQUITIN PROTEIN LIGASES was indexed under UBIQUITIN-PROTEIN LIGASES and ENDOSOMAL SORTING COMPLEXES REQUIRED FOR TRANSPORT 2005-2017; under LIGASES 1996-2004; and under CALCIUM-BINDING PROTEINS 1996-2003
History Note: 2018 (1996)
Date Established: 2018/01/01
Date of Entry: 2017/07/11
Revision Date: 2017/06/29

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M0453577
Scope Note: E3 ubiquitin ligases that consist of four WW DOMAINS. They accept UBIQUITIN from E2 UBIQUITIN-CONJUGATING ENZYME as a thioester via their C-terminal HECT domains and transfer it specifically to the 63rd LYSINE residue (Lys-63) of target proteins. NEDD4 targets include many proteins and receptors with important functions for cell growth and homeostasis such as VEGFR-2; FGFR1 TYROSINE KINASE; and ERBB-4 RECEPTOR. They play a critical role in the internalization of these receptors, their degradation by LYSOSOMES, and also function as part of the ESCRT complex in VIRUS RELEASE.
Terms: Nedd4 Ubiquitin Protein Ligases Preferred Term
Term UI T000923775
Date05/09/2017
LexicalTag ACX
ThesaurusID NLM (2003); Nedd4 Proteins
Term UI T000923777
Date05/09/2017
LexicalTag ACX
ThesaurusID NLM (2018); Neuronal Precursor Cell-Expressed Developmentally Down-Regulated 4 Ligase
Term UI T000923776
Date05/09/2017
LexicalTag NON
ThesaurusID NLM (2003)

Nedd4 Ubiquitin Protein Ligases MeSH Descriptor Data 2025