MeSH Browser

MeSH Heading: Polypyrimidine Tract-Binding Protein
Tree Number(s): D12.776.157.725.829.250; D12.776.664.962.829.250
Unique ID: D038941
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D038941
Scope Note: A RNA-binding protein that binds to polypyriminidine rich regions in the INTRONS of messenger RNAs. Polypyrimidine tract-binding protein may be involved in regulating the ALTERNATIVE SPLICING of mRNAs since its presence on an intronic RNA region that is upstream of an EXON inhibits the splicing of the exon into the final mRNA product.
Entry Term(s): PTB Protein; PTB Splicing Factor; p57 Cytoplasmic RNA-Binding Protein; pPTB
Previous Indexing: Ribonucleoproteins (1991-2002); RNA-Binding Proteins (1991-2002)
Public MeSH Note: 2003; POLYPYRIMIDINE TRACT-BINDING PROTEIN was indexed under RIBONUCLEOPROTEINS & RNA-BINDING PROTEINS 1991-2002
History Note: 2003; use POLYPYRIMIDINE TRACT-BINDING PROTEIN (NM) 1991-2002
Date Established: 2003/01/01
Date of Entry: 2002/07/03
Revision Date: 2016/07/05

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M0190270
Scope Note: A RNA-binding protein that binds to polypyriminidine rich regions in the INTRONS of messenger RNAs. Polypyrimidine tract-binding protein may be involved in regulating the ALTERNATIVE SPLICING of mRNAs since its presence on an intronic RNA region that is upstream of an EXON inhibits the splicing of the exon into the final mRNA product.
Terms: Polypyrimidine Tract-Binding Protein Preferred Term
Term UI T220275
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2003); pPTB
Term UI T220274
Date01/01/1955
LexicalTag ACR
ThesaurusID NLM (2003); PTB Protein
Term UI T427639
Date10/31/2000
LexicalTag ACX
ThesaurusID NLM (2003); PTB Splicing Factor
Term UI T427640
Date10/31/2000
LexicalTag ACX
ThesaurusID NLM (2003); p57 Cytoplasmic RNA-Binding Protein
Term UI T427641
Date10/31/2000
LexicalTag ACX
ThesaurusID NLM (2003)

Polypyrimidine Tract-Binding Protein MeSH Descriptor Data 2025