MeSH Browser

MeSH Heading: Alternative Splicing
Tree Number(s): G02.111.760.700.100; G03.839.700.100; G05.308.700.700.100
Unique ID: D017398
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D017398
Annotation: for NESTED TRANSCRIPTS also index the RNA; do not confuse with NESTED GENES; for nested primers use NESTED PCR; (POLYMERASE CHAIN REACTION)
Scope Note: A process whereby multiple RNA transcripts are generated from a single gene. Alternative splicing involves the splicing together of other possible sets of EXONS during the processing of some, but not all, transcripts of the gene. Thus a particular exon may be connected to any one of several alternative exons to form a mature RNA. The alternative forms of mature MESSENGER RNA produce PROTEIN ISOFORMS in which one part of the isoforms is common while the other parts are different.
Entry Term(s): Alternate Splicing; Nested Transcripts; RNA Splicing, Alternative; Splicing, Alternative
Previous Indexing: RNA Splicing (1982-1992)
See Also: Nested Genes; Protein Isoforms; RNA Splice Sites
Public MeSH Note: 93
History Note: 93
Date Established: 1993/01/01
Date of Entry: 1992/05/13
Revision Date: 2016/05/02

Allowable Qualifiers: drug effects (DE)

ethics (ES)

genetics (GE)

immunology (IM)

physiology (PH)

radiation effects (RE)

Concept UI: M0026412
Scope Note: A process whereby multiple RNA transcripts are generated from a single gene. Alternative splicing involves the splicing together of other possible sets of EXONS during the processing of some, but not all, transcripts of the gene. Thus a particular exon may be connected to any one of several alternative exons to form a mature RNA. The alternative forms of mature MESSENGER RNA produce PROTEIN ISOFORMS in which one part of the isoforms is common while the other parts are different.
Terms: Alternative Splicing Preferred Term
Term UI T052018
Date01/01/1999
LexicalTag NON
ThesaurusID NLM (1993); Splicing, Alternative
Term UI T052017
Date03/30/1992
LexicalTag NON
ThesaurusID NLM (1993); RNA Splicing, Alternative
Term UI T052019
Date03/20/1992
LexicalTag NON
ThesaurusID NLM (1993); Alternate Splicing
Term UI T482562
Date02/19/2002
LexicalTag NON
ThesaurusID NLM (2003)

Alternative Splicing MeSH Descriptor Data 2025