MeSH Browser

MeSH Heading: RNA, Messenger
Tree Number(s): D13.444.735.544
Unique ID: D012333
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D012333
Scope Note: RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
Entry Term(s): Messenger RNA; Messenger RNA, Polyadenylated; Non-Polyadenylated mRNA; Poly(A) RNA; Poly(A) Tail; Poly(A)+ RNA; Poly(A)+ mRNA; Polyadenylated mRNA; RNA, Messenger, Polyadenylated; RNA, Polyadenylated; mRNA; mRNA, Non-Polyadenylated; mRNA, Polyadenylated
NLM Classification #: QU 58.7
Public MeSH Note: 65; NON-POLYADENYLATED MRNA was indexed under RNA, MESSENGER 1981-94; POLYADENYLATED MRNA & POLY(A) RNA were indexed under POLY A & RNA, MESSENGER 1980-94
Online Note: use RNA, MESSENGER (NM) to search MRNA, NON-POLYADENYLATED 1981-94, MRNA, POLYADENYLATED 1980-94, & POLY(A)+ RNA 1980-94
History Note: 65(64); MRNA, NON-POLYADENYLATED was NON-POLYADENYLATED MRNA (NM) 1981-94; MRNA, POLYADENYLATED was POLYADENYLATED MRNA (NM) 1980-94; POLY(A)+ RNA was SY to POLY(A) RNA (NM) 1980-94
Date Established: 1965/01/01
Date of Entry: 1999/01/01
Revision Date: 2016/07/05

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Nucleic Acids, Nucleotides, and Nucleosides [D13]
- Nucleic Acids [D13.444]
  - RNA [D13.444.735]

RNA, Messenger Preferred

Concept UI: M0019167
Scope Note: RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
Terms: RNA, Messenger Preferred Term
Term UI T036617
Date01/01/1999
LexicalTag ACX
ThesaurusID NLM (1964); Messenger RNA
Term UI T036616
Date01/02/1990
LexicalTag NON
ThesaurusID NLM (1991); mRNA
Term UI T036618
Date01/02/1990
LexicalTag ABB
ThesaurusID NLM (1991)

mRNA, Non-Polyadenylated Narrower

mRNA, Polyadenylated Narrower

Concept UI: M0019169
Terms: mRNA, Polyadenylated Preferred Term
Term UI T036622
Date02/02/1994
LexicalTag NON
ThesaurusID NLM (1995); Polyadenylated mRNA
Term UI T036621
Date03/11/1994
LexicalTag NON
ThesaurusID NLM (1995); Messenger RNA, Polyadenylated
Term UI T036624
Date02/02/1994
LexicalTag NON
ThesaurusID NLM (1995); RNA, Messenger, Polyadenylated
Term UI T036625
Date02/02/1994
LexicalTag NON
ThesaurusID NLM (1995); Poly(A)+ mRNA
Term UI T036623
Date02/02/1994
LexicalTag NON
ThesaurusID NLM (1995)

RNA, Polyadenylated Narrower

Poly(A) Tail Narrower

RNA, Messenger MeSH Descriptor Data 2025