MeSH Browser

MeSH Heading: Trans-Splicing
Tree Number(s): G02.111.760.700.750; G03.839.700.750; G05.308.700.700.750
Unique ID: D020040
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D020040
Annotation: note category: a physiol process taking place within the cell nucleus; do not confuse with DNA, RECOMBINANT; CLONING, MOLECULAR; or GENETIC ENGINEERING
Scope Note: The joining of RNA from two different genes. One type of trans-splicing is the "spliced leader" type (primarily found in protozoans such as trypanosomes and in lower invertebrates such as nematodes) which results in the addition of a capped, noncoding, spliced leader sequence to the 5' end of mRNAs. Another type of trans-splicing is the "discontinuous group II introns" type (found in plant/algal chloroplasts and plant mitochondria) which results in the joining of two independently transcribed coding sequences. Both are mechanistically similar to conventional nuclear pre-mRNA cis-splicing. Mammalian cells are also capable of trans-splicing.
Entry Term(s): RNA Trans-Splicing; Trans RNA Splicing; Trans Splicing
Previous Indexing: RNA Splicing (1982-1998)
See Also: RNA, Spliced Leader
Public MeSH Note: 99
History Note: 99
Date Established: 1999/01/01
Date of Entry: 1998/06/11
Revision Date: 2016/07/01

Allowable Qualifiers: drug effects (DE)

ethics (ES)

genetics (GE)

immunology (IM)

physiology (PH)

radiation effects (RE)

Concept UI: M0029753
Scope Note: The joining of RNA from two different genes. One type of trans-splicing is the "spliced leader" type (primarily found in protozoans such as trypanosomes and in lower invertebrates such as nematodes) which results in the addition of a capped, noncoding, spliced leader sequence to the 5' end of mRNAs. Another type of trans-splicing is the "discontinuous group II introns" type (found in plant/algal chloroplasts and plant mitochondria) which results in the joining of two independently transcribed coding sequences. Both are mechanistically similar to conventional nuclear pre-mRNA cis-splicing. Mammalian cells are also capable of trans-splicing.
Terms: Trans-Splicing Preferred Term
Term UI T059701
Date01/01/1999
LexicalTag NON
ThesaurusID NLM (1999); Trans Splicing
Term UI T059700
Date01/14/1998
LexicalTag NON
ThesaurusID NLM (1999); RNA Trans-Splicing
Term UI T059698
Date01/14/1998
LexicalTag NON
ThesaurusID NLM (1999); Trans RNA Splicing
Term UI T059699
Date01/14/1998
LexicalTag NON
ThesaurusID NLM (1999)

Trans-Splicing MeSH Descriptor Data 2023