MeSH Browser

MeSH Heading: DNA Polymerase gamma
Tree Number(s): D08.811.913.696.445.308.300.169; D12.776.575.280
Unique ID: D000074002
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D000074002
Scope Note: A DNA-directed DNA polymerase that functions in the replication of MITOCHONDRIAL DNA. Mutations in the gene that encodes this enzyme (POLG) are associated with some forms of OPHTHALMOPLEGIA, CHRONIC EXTERNAL PROGRESSIVE.
Entry Term(s): DNA Polymerase Subunit gamma-1; Mitochondrial DNA Polymerase; PolG-alpha
Registry Numbers: EC 2.7.7.7
Public MeSH Note: 2018; DNA POLYMERASE GAMMA was indexed under DNA-DIRECTED DNA POLYMERASE 1997-2017
History Note: 2018 (1997)
Date Established: 2018/01/01
Date of Entry: 2017/07/11
Revision Date: 2020/06/22

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M000625126
Registry Numbers: EC 2.7.7.7
Scope Note: A DNA-directed DNA polymerase that functions in the replication of MITOCHONDRIAL DNA. Mutations in the gene that encodes this enzyme (POLG) are associated with some forms of OPHTHALMOPLEGIA, CHRONIC EXTERNAL PROGRESSIVE.
Terms: DNA Polymerase gamma Preferred Term
Term UI T000913446
Date12/30/2016
LexicalTag NON
ThesaurusID NLM (1977); DNA Polymerase Subunit gamma-1
Term UI T001079644
Date04/30/2020
LexicalTag NON
ThesaurusID NLM (2021); PolG-alpha
Term UI T001079645
Date04/30/2020
LexicalTag NON
ThesaurusID NLM (2021); Mitochondrial DNA Polymerase
Term UI T000913444
Date12/30/2016
LexicalTag NON
ThesaurusID NLM (2018)

DNA Polymerase gamma MeSH Descriptor Data 2025