MeSH Browser

MeSH Heading: DNA Polymerase II
Tree Number(s): D08.811.913.696.445.308.300.230
Unique ID: D004257
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D004257
Scope Note: A DNA-dependent DNA polymerase characterized in E. coli and other lower organisms. It may be present in higher organisms and has an intrinsic molecular activity only 5% of that of DNA Polymerase I. This polymerase has 3'-5' exonuclease activity, is effective only on duplex DNA with gaps or single-strand ends of less than 100 nucleotides as template, and is inhibited by sulfhydryl reagents.
Entry Term(s): DNA Pol II; DNA Polymerase epsilon; DNA-Dependent DNA Polymerase II
Previous Indexing: DNA Nucleotidyltransferases (1968-1976)
Public MeSH Note: 84; see DNA POLYMERASES 1977-83; DNA POLYMERASE EPSILON was indexed under DNA POLYMERASES 1994-97
History Note: 84(77); for DNA POLYMERASE EPSILON use DNA POLYMERASE II (NM) 1994-97
Date Established: 1984/01/01
Date of Entry: 1976/04/21
Revision Date: 2020/06/22

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M0006662
Scope Note: A DNA-dependent DNA polymerase characterized in E. coli and other lower organisms. It may be present in higher organisms and has an intrinsic molecular activity only 5% of that of DNA Polymerase I. This polymerase has 3'-5' exonuclease activity, is effective only on duplex DNA with gaps or single-strand ends of less than 100 nucleotides as template, and is inhibited by sulfhydryl reagents.
Terms: DNA Polymerase II Preferred Term
Term UI T012938
Date01/01/1999
LexicalTag ACX
ThesaurusID NLM (1977); DNA Pol II
Term UI T840529
Date04/16/2013
LexicalTag ABB
ThesaurusID NLM (2014); DNA Polymerase epsilon
Term UI T012941
Date03/06/1997
LexicalTag NON
ThesaurusID NLM (1998); DNA-Dependent DNA Polymerase II
Term UI T012939
Date04/20/1976
LexicalTag NON
ThesaurusID UNK (19XX)

DNA Polymerase II MeSH Descriptor Data 2025