MeSH Browser

MeSH Heading: DNA Polymerase I
Tree Number(s): D08.811.913.696.445.308.300.225
Unique ID: D004256
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D004256
Scope Note: A DNA-dependent DNA polymerase characterized in prokaryotes and may be present in higher organisms. It has both 3'-5' and 5'-3' exonuclease activity, but cannot use native double-stranded DNA as template-primer. It is not inhibited by sulfhydryl reagents and is active in both DNA synthesis and repair.
Entry Term(s): DNA Pol I; DNA Polymerase alpha; DNA-Dependent DNA Polymerase I; Klenow Fragment
Previous Indexing: DNA Nucleotidyltransferases (1968-1976)
Public MeSH Note: 84; see DNA POLYMERASES 1977-83; for DNA POLYMERASE ALPHA see DNA POLYMERASE II 1982-97
History Note: 84(77); for DNA POLYMERASE ALPHA use DNA POLYMERASE II 1982-97
Date Established: 1984/01/01
Date of Entry: 1976/04/21
Revision Date: 2020/06/22

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M0006661
Scope Note: A DNA-dependent DNA polymerase characterized in prokaryotes and may be present in higher organisms. It has both 3'-5' and 5'-3' exonuclease activity, but cannot use native double-stranded DNA as template-primer. It is not inhibited by sulfhydryl reagents and is active in both DNA synthesis and repair.
Terms: DNA Polymerase I Preferred Term
Term UI T012934
Date01/01/1999
LexicalTag ACX
ThesaurusID NLM (1977); DNA Pol I
Term UI T845112
Date06/04/2013
LexicalTag ABB
ThesaurusID UNK (19XX); DNA Polymerase alpha
Term UI T012933
Date03/06/1997
LexicalTag NON
ThesaurusID NLM (1998); DNA-Dependent DNA Polymerase I
Term UI T012935
Date04/20/1976
LexicalTag NON
ThesaurusID UNK (19XX); Klenow Fragment
Term UI T012936
Date03/20/1990
LexicalTag EPO
ThesaurusID NLM (1991)

DNA Polymerase I MeSH Descriptor Data 2025