MeSH Browser

MeSH Heading: DNA Polymerase III
Tree Number(s): D08.811.913.696.445.308.300.235
Unique ID: D004258
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D004258
Scope Note: A DNA-dependent DNA polymerase characterized in E. coli and other lower organisms but may be present in higher organisms. Use also for a more complex form of DNA polymerase III designated as DNA polymerase III* or pol III* which is 15 times more active biologically than DNA polymerase I in the synthesis of DNA. This polymerase has both 3'-5' and 5'-3' exonuclease activities, is inhibited by sulfhydryl reagents, and has the same template-primer dependence as pol II.
Entry Term(s): DNA Pol III; DNA Polymerase delta; DNA-Dependent DNA Polymerase III
Previous Indexing: DNA Nucleotidyltransferases (1968-1976)
Public MeSH Note: 91; see DNA POLYMERASES 1977-90, DNA POLYMERASE DELTA was indexed under DNA POLYMERASES 1980-97
History Note: 91(77); for DNA POLYMERASE DELTA use DNA POLYMERASE III (NM) 1980-97
Date Established: 1991/01/01
Date of Entry: 1976/04/21
Revision Date: 2020/06/22

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M0006663
Scope Note: A DNA-dependent DNA polymerase characterized in E. coli and other lower organisms but may be present in higher organisms. Use also for a more complex form of DNA polymerase III designated as DNA polymerase III* or pol III* which is 15 times more active biologically than DNA polymerase I in the synthesis of DNA. This polymerase has both 3'-5' and 5'-3' exonuclease activities, is inhibited by sulfhydryl reagents, and has the same template-primer dependence as pol II.
Terms: DNA Polymerase III Preferred Term
Term UI T012942
Date01/01/1999
LexicalTag ACX
ThesaurusID NLM (1977); DNA Polymerase delta
Term UI T012945
Date03/06/1997
LexicalTag NON
ThesaurusID NLM (1998); DNA-Dependent DNA Polymerase III
Term UI T012943
Date04/20/1976
LexicalTag NON
ThesaurusID UNK (19XX); DNA Pol III
Term UI T845113
Date06/04/2013
LexicalTag ABB
ThesaurusID UNK (19XX)

DNA Polymerase III MeSH Descriptor Data 2025