MeSH Browser

MeSH Heading: Iron Regulatory Protein 1
Tree Number(s): D08.811.520.241.300.050.500; D12.776.157.427.374.375.960; D12.776.157.725.374; D12.776.494.500; D12.776.556.579.374.375.960; D12.776.664.962.374
Unique ID: D035941
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D035941
Scope Note: A multifunctional iron-sulfur protein that is both an iron regulatory protein and cytoplasmic form of aconitate hydratase. It binds to iron regulatory elements found on mRNAs involved in iron metabolism and regulates their translation. Its RNA binding ability and its aconitate hydrolase activity are dependent upon availability of IRON.
Entry Term(s): ACO1 Protein; Aconitase 1, Soluble; Ferritin Repressor Protein; IRE-BP1; IRP-1 Protein; IRP1 Protein
Previous Indexing: Iron-Sulfur Proteins (1995-2002); Ribonucleoproteins (1995-2002)
Public MeSH Note: 2003; FERRITIN REPRESSOR PROTEIN was indexed under IRON-SULFUR PROTEINS & RNA-BINDING PROTEINS 1991-2002, IRE-BP1, IRON REGULATORY PROTEIN 1, IRP-1 PROTEIN & IRP1 PROTEIN were indexed under IRON-SULFUR PROTEINS & RNA-BINDING PROTEINS 1995-2002
History Note: 2003; for FERRITIN REPRESSOR PROTEIN use IRON-REGULATORY PROTEINS (NM) 1991-2002, for IRE-BP1, IRON REGULATORY PROTEIN 1, IRP-1 PROTEIN & IRP1 PROTEIN use IRON-REGULATORY PROTEINS (NM) 1995-2002
Date Established: 2003/01/01
Date of Entry: 2002/07/02
Revision Date: 2006/07/05

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M0175229
Scope Note: A multifunctional iron-sulfur protein that is both an iron regulatory protein and cytoplasmic form of aconitate hydratase. It binds to iron regulatory elements found on mRNAs involved in iron metabolism and regulates their translation. Its RNA binding ability and its aconitate hydrolase activity are dependent upon availability of IRON.
Terms: Iron Regulatory Protein 1 Preferred Term
Term UI T205242
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2003); IRP-1 Protein
Term UI T205237
Date01/01/1955
LexicalTag ABX
ThesaurusID NLM (2003); IRP1 Protein
Term UI T205239
Date01/01/1955
LexicalTag ABX
ThesaurusID NLM (2003); IRE-BP1
Term UI T205234
Date01/01/1955
LexicalTag ABX
ThesaurusID NLM (2003); Aconitase 1, Soluble
Term UI T475075
Date12/27/2001
LexicalTag NON
ThesaurusID NLM (2003); ACO1 Protein
Term UI T475076
Date12/27/2001
LexicalTag NON
ThesaurusID NLM (2003); Ferritin Repressor Protein
Term UI T205241
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2003)

Iron Regulatory Protein 1 MeSH Descriptor Data 2025