NLM Logo

Iron Regulatory Protein 1 MeSH Descriptor Data 2023


MeSH Heading
Iron Regulatory Protein 1
Tree Number(s)
D08.811.520.241.300.050.500
D12.776.157.427.374.375.960
D12.776.157.725.374
D12.776.494.500
D12.776.556.579.374.375.960
D12.776.664.962.374
Unique ID
D035941
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D035941
Scope Note
A multifunctional iron-sulfur protein that is both an iron regulatory protein and cytoplasmic form of aconitate hydratase. It binds to iron regulatory elements found on mRNAs involved in iron metabolism and regulates their translation. Its RNA binding ability and its aconitate hydrolase activity are dependent upon availability of IRON.
Entry Term(s)
ACO1 Protein
Aconitase 1, Soluble
Ferritin Repressor Protein
IRE-BP1
IRP-1 Protein
IRP1 Protein
Registry Number
EC 4.2.1.3
Previous Indexing
Iron-Sulfur Proteins (1995-2002)
Ribonucleoproteins (1995-2002)
Public MeSH Note
2003; FERRITIN REPRESSOR PROTEIN was indexed under IRON-SULFUR PROTEINS & RNA-BINDING PROTEINS 1991-2002, IRE-BP1, IRON REGULATORY PROTEIN 1, IRP-1 PROTEIN & IRP1 PROTEIN were indexed under IRON-SULFUR PROTEINS & RNA-BINDING PROTEINS 1995-2002
History Note
2003; for FERRITIN REPRESSOR PROTEIN use IRON-REGULATORY PROTEINS (NM) 1991-2002, for IRE-BP1, IRON REGULATORY PROTEIN 1, IRP-1 PROTEIN & IRP1 PROTEIN use IRON-REGULATORY PROTEINS (NM) 1995-2002
Date Established
2003/01/01
Date of Entry
2002/07/02
Revision Date
2006/07/05
Iron Regulatory Protein 1 Preferred
page delivered in 0.177s