MeSH Browser

MeSH Heading: Protein Deglycase DJ-1
Tree Number(s): D08.811.277.785; D12.776.705.875
Unique ID: D000071617
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D000071617
Scope Note: A protein deglycase that repairs methylglyoxal- and glyoxal-glycated amino acids and proteins, releasing repaired proteins and lactate or glycolate. It deglycates CYSTEINE, ARGININE and LYSINE residues to reactivate proteins by reversing glycation and prevent the formation of ADVANCED GLYCATION END PRODUCTS. It protects cells against OXIDATIVE STRESS and CELL DEATH by functioning as an oxidative stress sensor and redox-sensitive MOLECULAR CHAPERONE and PROTEASE. Mutations in the PARK7 gene are associated with autosomal-recessive, early-onset PARKINSON DISEASE.
Entry Term(s): DJ-1 Protein; DJ-1-PARK7 Protein; DJ1 Protein; PARK7 Protein; Parkinson Protein 7; Parkinsonism Associated Deglycase
Previous Indexing: Intracellular Signaling Peptides and Proteins (1997-2016); Oncogene Proteins (1997-2016)
Public MeSH Note: 2017
History Note: 2017
Date Established: 2017/01/01
Date of Entry: 2016/07/08
Revision Date: 2022/07/12

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M000615251
Scope Note: A protein deglycase that repairs methylglyoxal- and glyoxal-glycated amino acids and proteins, releasing repaired proteins and lactate or glycolate. It deglycates CYSTEINE, ARGININE and LYSINE residues to reactivate proteins by reversing glycation and prevent the formation of ADVANCED GLYCATION END PRODUCTS. It protects cells against OXIDATIVE STRESS and CELL DEATH by functioning as an oxidative stress sensor and redox-sensitive MOLECULAR CHAPERONE and PROTEASE. Mutations in the PARK7 gene are associated with autosomal-recessive, early-onset PARKINSON DISEASE.
Terms: Protein Deglycase DJ-1 Preferred Term
Term UI T000896172
Date02/29/2016
LexicalTag NON
ThesaurusID NLM (2017); PARK7 Protein
Term UI T000896173
Date02/29/2016
LexicalTag ABX
ThesaurusID NLM (2017); DJ-1-PARK7 Protein
Term UI T000896174
Date02/29/2016
LexicalTag ABX
ThesaurusID NLM (2017); Parkinsonism Associated Deglycase
Term UI T000896175
Date02/29/2016
LexicalTag NON
ThesaurusID NLM (2017); Parkinson Protein 7
Term UI T000896176
Date02/29/2016
LexicalTag NON
ThesaurusID NLM (2017); DJ1 Protein
Term UI T000896177
Date02/29/2016
LexicalTag ABX
ThesaurusID NLM (2017); DJ-1 Protein
Term UI T000896178
Date02/29/2016
LexicalTag ABX
ThesaurusID NLM (2017)

Protein Deglycase DJ-1 MeSH Descriptor Data 2025