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Protein Deglycase DJ-1 MeSH Descriptor Data 2023


MeSH Heading
Protein Deglycase DJ-1
Tree Number(s)
D08.811.277.785
D12.776.705.875
Unique ID
D000071617
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D000071617
Scope Note
A protein deglycase that repairs methylglyoxal- and glyoxal-glycated amino acids and proteins, releasing repaired proteins and lactate or glycolate. It deglycates CYSTEINE, ARGININE and LYSINE residues to reactivate proteins by reversing glycation and prevent the formation of ADVANCED GLYCATION END PRODUCTS. It protects cells against OXIDATIVE STRESS and CELL DEATH by functioning as an oxidative stress sensor and redox-sensitive MOLECULAR CHAPERONE and PROTEASE. Mutations in the PARK7 gene are associated with autosomal-recessive, early-onset PARKINSON DISEASE.
Entry Term(s)
DJ-1 Protein
DJ-1-PARK7 Protein
DJ1 Protein
PARK7 Protein
Parkinson Protein 7
Parkinsonism Associated Deglycase
Registry Number
EC 3.1.2.-
Previous Indexing
Intracellular Signaling Peptides and Proteins (1997-2016)
Oncogene Proteins (1997-2016)
Public MeSH Note
2017
History Note
2017
Date Established
2017/01/01
Date of Entry
2016/07/08
Revision Date
2022/07/12
Protein Deglycase DJ-1 Preferred
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