- Concept UI
- M000613241
- Registry Numbers
- EC 2.7.11.1
- Scope Note
- A serine/threonine protein kinase with GTPase activity that contains 12 LEUCINE-rich repeats in its central region and 7 WD repeats C-terminal to its kinase and GTPase domains. It localizes to TRANSPORT VESICLES; the OUTER MITOCHONDRIAL MEMBRANE; and the GOLGI APPARATUS. It functions in PROTEIN TRANSPORT; regulates neuron morphology in the central nervous system, and also functions in the trafficking of SYNAPTIC VESICLES. Mutations in the LRRK2 gene have been identified in autosomal dominant cases of PARKINSON DISEASE (PARK8).
- Terms
-
Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
Preferred Term
Term UI
T000892979
Date12/31/2015
LexicalTag
NON
ThesaurusID
NLM (2017)
-
LRRK2 Protein
Term UI
T000892980
Date12/31/2015
LexicalTag
ABX
ThesaurusID
NLM (2017)
-
PARK8 Protein
Term UI
T000892981
Date12/31/2015
LexicalTag
ABX
ThesaurusID
NLM (2017)
-
Dardarin Protein
Term UI
T000892982
Date12/31/2015
LexicalTag
NON
ThesaurusID
NLM (2017)