NLM Logo

WNK Lysine-Deficient Protein Kinase 1 MeSH Descriptor Data 2023


MeSH Heading
WNK Lysine-Deficient Protein Kinase 1
Tree Number(s)
D08.811.913.696.620.682.700.982
D12.776.476.563.982
D23.050.301.500.600.962
D23.050.705.552.600.925
Unique ID
D000076204
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D000076204
Scope Note
A serine-threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival, and proliferation. It functions as an activator and inhibitor of sodium-coupled chloride co-transporters and as an inhibitor of potassium-coupled chloride co-transporters. Mutations in the WNK1 gene are associated with type 2C PSEUDOHYPOALDOSTERONISM and type 2A HEREDITARY SENSORY AND AUTONOMIC NEUROPATHIES.
Registry Number
EC 2.7.11.1
Previous Indexing
Intracellular Signaling Peptides and Proteins (2005-2017)
Minor Histocompatibility Antigens (2005-2017)
Protein-Serine-Threonine Kinases (2005-2017)
Public MeSH Note
2018
History Note
2018
Date Established
2018/01/01
Date of Entry
2017/07/11
Revision Date
2021/06/28
WNK Lysine-Deficient Protein Kinase 1 Preferred
page delivered in 0.178s